Existing antibacterial vaccines

Mendoza, Natalia; Ravanfar, Parisa; Satyaprakah, Anita; Pillai, Syamkumar Reghu Nandanan; Creed, Rosella

doi:10.1111/j.1529-8019.2009.01225.x

Cited by 21 publications

(19 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1, 2 Meanwhile, existing antibiotic regimens are increasingly threatened by the rapid emergence of bacterial drug resistance. 3 Together, these challenges have motivated the search for novel antibacterial vaccine strategies.…”

Section: Introductionmentioning

confidence: 99%

Modulating Antibacterial Immunity via Bacterial Membrane-Coated Nanoparticles

et al. 2015

View full text Add to dashboard Cite

Synthetic nanoparticles coated with cellular membranes have been increasingly explored to harness natural cell functions toward the development of novel therapeutic strategies. Herein, we report on a unique bacterial membrane-coated nanoparticle system as a new and exciting antibacterial vaccine. Using Escherichia coli as a model pathogen, we collect bacterial outer membrane vesicles (OMVs) and successfully coat them onto small gold nanoparticles (AuNPs) with a diameter of 30 nm. The resulting bacterial membrane-coated AuNPs (BM-AuNPs) show markedly enhanced stability in biological buffer solutions. When injected subcutaneously, the BM-AuNPs induce rapid activation and maturation of dendritic cells in the lymph nodes of the vaccinated mice. In addition, vaccination with BM-AuNPs generates antibody responses that are durable and of higher avidity than those elicited by OMVs only. The BM-AuNPs also induce an elevated production of interferon gamma (INFγ) and interleukin-17 (IL-17), but not interleukin-4 (IL-4), indicating its capability of generating strong Th1 and Th17 biased cell responses against the source bacteria. These observed results demonstrate that using natural bacterial membranes to coat synthetic nanoparticles holds great promise for designing effective antibacterial vaccines.

show abstract

Section: Introductionmentioning

confidence: 99%

Modulating Antibacterial Immunity via Bacterial Membrane-Coated Nanoparticles

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Caused mostly by the unregulated use of antimicrobials and poor hygienic conditions amongst others, it severely affects humans in every aspect of life [ 2 ]. Though immunization through vaccines has resulted in the control and eradication of some microbial infections [ 3 ] a vast majority rely solely on chemotherapy, which is constantly hampered by the emergence of resistant phenotypes. The increasing prevalence of these resistant phenotypes especially those with multiple resistances is responsible for most of the difficulties encountered in treating these diseases.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activities of a Plethora of Medicinal Plant Extracts and Hydrolates against Human Pathogens and Their Potential to Reverse Antibiotic Resistance

Njimoh

Nguedia

Mokake

et al. 2015

International Journal of Microbiology

View full text Add to dashboard Cite

Microbial infections till date remain a scourge of humanity due to lack of vaccine against some infections, emergence of drug resistant phenotypes, and the resurgence of infections amongst others. Continuous quest for novel therapeutic approaches remains imperative. Here we (i) assessed the effects of extracts/hydrolates of some medicinal plants on pathogenic microorganisms and (ii) evaluated the inhibitory potential of the most active ones in combination with antibiotics. Extract E03 had the highest DZI (25 mm). Extracts E05 and E06 were active against all microorganisms tested. The MICs and MBCs of the methanol extracts ranged from 16.667 × 103 μg/mL to 2 μg/mL and hydrolates from 0.028 to 333333 ppm. Extract E30 had the highest activity especially against S. saprophyticus (MIC of 6 ppm) and E. coli (MIC of 17 ppm). Combination with conventional antibiotics was shown to overcome resistance especially with E30. Analyses of the extracts revealed the presence of alkaloids, flavonoids, triterpenes, steroids, phenols, and saponins. These results justify the use of these plants in traditional medicine and the practice of supplementing decoctions/concoctions with conventional antibiotics. Nauclea pobeguinii (E30), the most active and synergistic of all these extracts, and some hydrolates with antimicrobial activity need further exploration for the development of novel antimicrobials.

show abstract

“…They have achieved remarkable success in controlling past epidemics worldwide [ 1 ]. In current practice, the use of antibacterial vaccines, including whole-cell bacteria, killed or inactivated bacteria, subunit vaccines made of bacterial proteins or polysaccharides, and inactivated bacterial toxins (toxoids), have drastically reduced global morbidity and mortality [ 1 , 2 ]. Despite such success, effective vaccines remain largely unavailable for the treatment and prevention of a number of serious bacterial infections, including those caused by pathogenic Staphylococcus aureus, Helicobacter pylori , Shigella , and Escherichia coli ( E. coli ) [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform

et al. 2015

View full text Add to dashboard Cite

Nanoparticles have demonstrated unique advantages in enhancing immunotherapy potency and have drawn increasing interest in developing safe and effective vaccine formulations. Recent technological advancement has led to the discovery and development of cell membrane-coated nanoparticles, which combine the rich functionalities of cellular membranes and the engineering flexibility of synthetic nanomaterials. This new class of biomimetic nanoparticles has inspired novel vaccine design strategies with strong potential for modulating antibacterial immunity. This article will review recent progress on using cell membrane-coated nanoparticles for antibacterial vaccination. Specifically, two major development strategies will be discussed, namely (i) vaccination against virulence factors through bacterial toxin sequestration; and (ii) vaccination against pathogens through mimicking bacterial antigen presentation.

show abstract

Existing antibacterial vaccines

Cited by 21 publications

References 42 publications

Modulating Antibacterial Immunity via Bacterial Membrane-Coated Nanoparticles

Modulating Antibacterial Immunity via Bacterial Membrane-Coated Nanoparticles

Antimicrobial Activities of a Plethora of Medicinal Plant Extracts and Hydrolates against Human Pathogens and Their Potential to Reverse Antibiotic Resistance

Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform

Contact Info

Product

Resources

About