In the present paper we discuss the existence and uniqueness of solution for higherorder calculus of variations problems, involving composition of functionals. Also, higher-order DuBois-Reymond conditions in the Sobolev space W m,p ([t1, t2]; R) are proven, both in integral and differential form, and under additional constraints. We consider the higher-order Noether's theorem and discuss invariance conditions for the main problem.