Exhaled Pentane Levels in Acute Asthma

Olopade, Christopher O.; Zakkar, Mohamed; Swedler, William I.; Rubinstein, Israel

doi:10.1378/chest.111.4.862

Cited by 143 publications

(88 citation statements)

References 15 publications

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“…Exhaled pentane has been proposed as such a marker for airway pathology [10], and available evidence suggests that peroxidation of polyunsaturated fatty acids in the liver is its major source. Increased pentane concentrations were reported in the breath of patients with acute asthma [19], pulmonary infections [20] and after acute cigarette smoke exposure [21]. A single observation in adult CF patients has previously been reported in abstract form [22] and as letter to the editor [23], apparently without a subsequent original contribution.…”

Section: Discussionmentioning

confidence: 99%

Volatile organic compounds in the exhaled breath of young patients with cystic fibrosis

Barker

Hengst²,

Schmid³

et al. 2006

Eur Respir J

161

124

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Inflammatory mediators in the exhaled breath are receiving growing medical interest as noninvasive disease markers. Volatile organic compounds have been investigated in this context, but clinical information and methodological standards are limited.The levels of ethane, propane, n-pentane, methanol, ethanol, 2-propanol, acetone, isoprene, benzene, toluene, dimethyl sulphide (DMS) and limonene were measured in repeated breath samples from 20 cystic fibrosis patients and 20 healthy controls (aged 8-29 yrs). Three endexhaled and one ambient air sample were collected per person and analysed on a customised gas chromatography system. Intra-subject coefficients of variation ranged between 9 and 34%, and hydrocarbon breath levels were influenced by their inspired concentrations. The alveolar gradient for pentane was higher in cystic fibrosis patients than in healthy controls (0.36 versus 0.21 ppb) and inversely proportional to forced expiratory volume in one second; highest values were observed in patients with pulmonary exacerbations (0.73 versus 0.24 ppb). Cystic fibrosis patients also exhibited a lower output of DMS (3.9 versus 7.6 ppb). Group differences were not significant for ethane and the remaining substances.It was concluded that chemical breath analysis for volatile organic compounds is feasible and may hold potential for the noninvasive diagnosis and follow-up of inflammatory processes in cystic fibrosis lung disease.

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Section: Discussionmentioning

confidence: 99%

Volatile organic compounds in the exhaled breath of young patients with cystic fibrosis

Barker

Hengst²,

Schmid³

et al. 2006

Eur Respir J

161

124

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“…They are generated by the free radical peroxidation of omega 6 (linoleic) and omega 3 (linolenic) polyunsaturated fatty acids. They have been used as non-invasive markers of active inflammation in obstructive sleep apnoea, 16 acute asthma (pentane), 47 colitis (animal model), 48 and rheumatoid arthritis 49 and as outcome measures in adults with adult respiratory distress syndrome 50 and chronic obstructive pulmonary disease 51 and premature newborns with respiratory distress syndrome. 52 In an animal model of colitis, increases in exhaled breath pentane were delayed until day 7 at which time histological examination confirmed acute colonic inflammation.…”

Section: Volatile Hydrocarbonsmentioning

confidence: 99%

Alcohol burns in extremely low birthweight infants: still occurring

Reynolds

Banerjee²,

Meek³

2005

Archives of Disease in Childhood - Fetal and Neonatal Edition

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“…Besides, it has a potential to be used for diagnostic purposes related to acute or chronic physiological disorders inside the human body, e.g., in inflammatory processes ͑acute asthma, inflammatory bowel disease͒ 20,21 or acute myocardial infarction. 22,23 With the recent development of new powerful all-solid-state tunable infrared lasers, 24,25 this method has a high potential in clinical applications.…”

mentioning

confidence: 99%

On-line laser photoacoustic detection of ethene in exhaled air as biomarker of ultraviolet radiation damage of the human skin

Harren¹,

Berkelmans²,

Kuiper³

et al. 1999

Applied Physics Letters

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The exhaled air and volatile emission by the skin of human subjects were analyzed for traces of ethene (C 2 H 4 ) by means of CO 2 laser photoacoustic trace gas detection. Due to the extreme sensitivity of the detection system ͑6 part per trillion volume, 6:10 12 ), these measurements could be performed on-line and noninvasively. Exhaled ethene was used as a biomarker for lipid peroxidation in the skin of human subjects exposed to ultraviolet ͑UV͒ radiation from a solarium. A change in the ethene concentration was already observed in the exhaled air after 2 min. Adaptation of the skin to UV exposure and direct skin emission could also be observed.

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Exhaled Pentane Levels in Acute Asthma

Cited by 143 publications

References 15 publications

Volatile organic compounds in the exhaled breath of young patients with cystic fibrosis

Volatile organic compounds in the exhaled breath of young patients with cystic fibrosis

Alcohol burns in extremely low birthweight infants: still occurring

On-line laser photoacoustic detection of ethene in exhaled air as biomarker of ultraviolet radiation damage of the human skin

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