On-line laser photoacoustic detection of ethene in exhaled air as biomarker of ultraviolet radiation damage of the human skin

Harren, F.J.M.; Berkelmans, R.; Kuiper, KC Koen; Hekkert, S. te Lintel; Scheepers, Paul T.J.; Dekhuijzen, R.; Hollander, Peter; Parker, David H.

doi:10.1063/1.123680

Cited by 59 publications

(48 citation statements)

References 19 publications

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“…Photoacoustic detection has been successfully employed in a wide range of scientific fields, e.g., in research related to the environment [56,57], medicine [58] and biology [59]. Kreuzer first reported the detection of very low concentra− tions of gases using photoacoustic detection in combination with a nonresonating cell [60].…”

Section: Infrared Laser Diode Photoacoustic Detectionmentioning

confidence: 99%

Infrared diode laser spectroscopy

Civiš

Cihelka²,

Matulková

2010

Opto-Electronics Review

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Three types of lasers (double-heterostructure 66 K InAsSb/InAsSbP laser diode, room temperature, multi quantum wells with distributed feedback (MQW with DFB) (GaInAsSb/AlGaAsSb based) diode laser and vertical cavity surface emitting lasers (VCSELs) (GaSb based) have been characterized using Fourier transform emission spectroscopy and compared. The photoacoustic technique was employed to determine the detection limit of formaldehyde (less than 1 ppmV) for the strongest absorption line of the v3 + v5 band in the emission region of the GaInAsSb/AlGaAsSb diode laser. The detection limit (less than 10 ppbV) of formaldehyde was achieved in the 2820 cm−1 spectral range in case of InAsSb/InAsSbP laser (fundamental bands of v1, v5). Laser sensitive detection (laser absorption together with high resolution Fourier transform infrared technique including direct laser linewidth measurement, infrared photoacoustic detection of neutral molecules (methane, form-aldehyde) is discussed.Additionally, very sensitive laser absorption techniques of such velocity modulation are discussed for case of laser application in laboratory research of molecular ions. Such sensitive techniques (originally developed for lasers) contributed very much in identifying laboratory microwave spectra of a series of anions (C6H−, C4H−, C2H−, CN−) and their discovery in the interstellar space (C6H−, C4H−).

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Section: Infrared Laser Diode Photoacoustic Detectionmentioning

confidence: 99%

Infrared diode laser spectroscopy

Civiš

Cihelka²,

Matulková

2010

Opto-Electronics Review

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“…The study of biological processes via the emission of volatile organic compounds (VOCs) is a widely used and accepted method in Life Sciences, including different fields of biology (Boschetti et al 1999, Phillips et al 1999, Harren et al 1999, Woltering et al 1989, Holzinger et al 2000, environmental monitoring (Hewitt et al 2003, Warneke et al 1996 and medical diagnostics (Phillips 1992, Berkelmans et al 2003, Jordan et al 1995, Karl et al 2001, Lechner et al 2005, Dannecker et al 1981, Steeghs et al 2006. Gas analysis is also becoming an important tool in control of industrial processes such as combustion and plasma diagnostics, investigation of engines or automobile exhaust measurements or headspace analysis during food production (Werle 2003, Lindinger 2005, Jobson 2005.…”

Section: Introductionmentioning

confidence: 99%

The suitability of Tedlar bags for breath sampling in medical diagnostic research

Steeghs

Cristescu²,

Harren³

2006

Physiol. Meas.

110

133

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Tedlar bags are tested for their suitability for breath sampling for medical diagnostic purposes. Proton-transfer reaction-mass spectrometry was used to monitor the changes in composition of various mixtures contained in custommade black-layered Tedlar bags. Characteristic ions at m/z 88 and 95 amu reflect considerable pollution from the bag material. The pollutant found on m/z 88 amu is most probably N,N-dimethylacetamide, a latent solvent used in the production of Tedlar film. Gas composition losses during filling were found to range from 5 to 47%, depending on the compound. Once stored, the half-lives of methanol, acetaldehyde, acetone, isoprene, benzene, toluene and styrene were estimated between 5 and 13 days. Losses from breath samples (52 h after filling) were found to be less than 10%. No observable decrease was found for ethylene over 3 days, using laser-based photoacoustic detection. For the use of Tedlar bags, a standardized protocol is advised, where the time point of analysis is fixed for all samples and should be kept as close as possible to the time of sampling.

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“…It is known that the 6) [27][28]. The ethylene product of lipid peroxidation in the skin during the UV exposure was examined using the laser-based photoacoustic method [5][6][29][30]. The total ethylene production depends on the amount of lipids that are attacked by ROS.…”

Section: Inhibitory Activity Of Lipid Peroxidation Using the Laser-bamentioning

confidence: 99%

“…Previous study has proved that the measurement of the exhaled volatile hydrocarbons ethylene (C 2 H 4 ) is an on-line and non-invasive method to monitor lipid peroxidation. The ethylene as a result of the lipid peroxidation during the UV exposure of the skin has been investigated using the laser-based photoacoustic method [5][6]. The human body contains antioxidants to fight against free radicals.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Lipid Peroxidation Induced by Ultraviolet Radiation by Crude Phlorotannis Isolated from Brown Algae <i>Sargassum hystrix v. buxifolium</i> C. Agardh

Harnita¹,

Santosa²,

Martono³

et al. 2013

Indones. J. Chem.

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This study examines the antioxidant activity of crude phlorotannins from the brown algae Sargassum hystrix v. buxifolium (Chauvin) J. Agardh, through the inhibition of a lipid peroxidation reaction that is induced by the UV radiation. The antioxidant activity during the UV exposure was investigated using the laser-based photoacoustic method for the detection of the ethylene as indicator for lipid peroxidation. This involves an experiment that isolated crude phlorotannins from the ethyl acetate fraction of the Sargassum hystrix methanol extract, hereafter referred to as PFSH. It results in the antioxidant activity as a potent lipid peroxidation inhibitor. Statistically, such antioxidant activity is not significantly different than the commercial antioxidant, which is vitamin C (p > 0.05). The amount of the total phlorotannins, using the Folin-Ciocalteu method, was measured to be approximately 0.13% w/w. In addition, it is found that PFSH contains phlorotannins with low molecular weight (MW) (<1000 Da). Keywords

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On-line laser photoacoustic detection of ethene in exhaled air as biomarker of ultraviolet radiation damage of the human skin

Cited by 59 publications

References 19 publications

Infrared diode laser spectroscopy

Infrared diode laser spectroscopy

The suitability of Tedlar bags for breath sampling in medical diagnostic research

Inhibition of Lipid Peroxidation Induced by Ultraviolet Radiation by Crude Phlorotannis Isolated from Brown Algae <i>Sargassum hystrix v. buxifolium</i> C. Agardh

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