Exhaled CO, a predictor of lung function?

Fabricius, P. G.; Scharling, Henrik; Løkke, Anders; Vestbo, Jørgen; Lange, Peter

doi:10.1016/j.rmed.2006.06.013

Cited by 11 publications

(10 citation statements)

References 21 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They also revealed a positive correlation between the exhaled CO level and the number of cigarettes per day and duration of smoking. In studies on the factors affecting the exhaled CO level in active smokers, the number of cigarettes per day, type of cigarette, method of smoking, and duration of smoking were found to be effective factors (11)(12)(13). In the study of Fabricius et al (12), the exhaled CO level was found to be lower in individuals who smoked unfiltered cigarettes and did not inhale smoke.…”

Section: Discussionmentioning

confidence: 93%

“…In studies on the factors affecting the exhaled CO level in active smokers, the number of cigarettes per day, type of cigarette, method of smoking, and duration of smoking were found to be effective factors (11)(12)(13). In the study of Fabricius et al (12), the exhaled CO level was found to be lower in individuals who smoked unfiltered cigarettes and did not inhale smoke. In another study, the exhaled CO level was found to be lower than 12 ppm in people who had not smoked within the previous 8 h and the level of exhaled CO reduced by half every 4.3 h without smoking (13).…”

Section: Discussionmentioning

confidence: 93%

“…In other studies that suggest the opposite, it was detected that the exhaled CO level was related to the current level of smoking in COPD patients but did not exhibit a correlation with the severity of COPD (15,16). On the other hand, in a study of a large population, it was concluded that the exhaled CO level could not be an indicator of pulmonary functions (17).…”

Section: Introductionmentioning

confidence: 89%

“…In a study, the mean CO level was found to be 17 ppm in healthy smokers, 3 ppm in healthy non-smokers, and 5 ppm in passive smokers (10). It was demonstrated in some studies that the number of cigarettes smoked per day, type of cigarette, duration of smoking, and method of smoking affected the exhaled CO level in active smokers (11)(12)(13). If active smokers do not smoke during the previous 8 h, the exhaled CO level is found to be below 12 ppm and the exhaled CO level is reduced by half every 4.3 h without smoking (13).…”

Section: Introductionmentioning

confidence: 98%

See 3 more Smart Citations

Does the Finding of Small Airway Obstruction in Pulmonary Function Tests Effect End-Expiratory Carbonmonoxide Level?

Salepçi¹

2015

Eurasian J Pulmonol

View full text Add to dashboard Cite

Objective: End-expiratory CO level, which is used to test smoking cessation is known to be effected by many factors. We aimed to evaluate effect of small airway obstruction (SAO) on end-expiratory CO levels. Methods:The study population consisted of cases who applied to smoking cessation clinic between April-December 2014. The duration of smoking (pack-years), pulmonary function tests (PFT) and end-expiratory carbonmonoxide (CO) were noted at first visit. The cases were questioned for last time of smoking and amount of cigarettes they smoked within past 12 hours. Pearson correlation test was used to determine factors effecting CO levels.Results: Mean age of 167 cases -112 male (67.1%), 55 female (32.9%) was 38.7±12.7 years. Mean duration of smoking was 23.3±16.4 pack-years, mean CO level was 14.1±6.9 ppm, mean FEF25-75% was 77.2±28.2. Mean period elapsed after last cigarette was 1.5±1.8 hours, mean number of cigarettes smoked within past 12 hours was 7.2±5.0. SAO was found in 50 cases (34.1%). Correlation analyses revealed that CO levels were correlated positively to duration of smoking and amount of cigarettes they smoked within past 12 hours (p=0.03, r=0.228; p=0.000, r=0.511, respectively) and negatively to the last time of smoking (p=0.023, r=0.176). SAO and in PFT was not correlated to CO level (p>0.05). Conclusion:End-expiratory CO level is closely related to duration of smoking, number of cigarettes smoked within past 12 hours and period elapsed after last cigarette. Presence of SAO does not seem to effect CO levels.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Does the Finding of Small Airway Obstruction in Pulmonary Function Tests Effect End-Expiratory Carbonmonoxide Level?

Salepçi¹

2015

Eurasian J Pulmonol

View full text Add to dashboard Cite

show abstract

“…Similarly, in a population survey of smokers from the Copenhagen Heart Study, eCO values were found to have no correlation with lung function or lung function decline in smokers either (8). Other authors have also failed to observe any association between eCO and lung function indices in stable patients with COPD (18).…”

Section: Discussionmentioning

confidence: 95%

Assessment of exhaled carbon monoxide in exacerbations of chronic obstructive pulmonary disease

2016

View full text Add to dashboard Cite

Introduction: Exhaled carbon monoxide (eCO) has been widely implicated as a pulmonary biomarker in respiratory diseases. The aim of this study was to investigate whether the treatment of patients with severe acute exacerbation of chronic obstructive pulmonary disease (AECOPD) could be aided by monitoring the changes in eCO. Methods: The levels of eCO along with routine clinical parameters were analyzed in 29 current smoker and 33 ex-smoker COPD patients, first at the time of hospital admission, and again at discharge following the standard treatment. Patients with AECOPD were also stratified according to sputum bacteria. Results: At exacerbation, the levels of eCO were increased in current smokers compared to ex-smokers (6.0 [2.0-9.5] versus 1.0 [1.0-2.0] ppm, p < 0.001). Similarly, eCO levels were higher in smokers after treatment (7.0 [2.0-12.5] versus 1.0 [1.0-2.0] ppm, p < 0.001). Treatment of AECOPD did not affect eCO concentrations. The levels of eCO were not statistically different between bacterial and non-bacterial AECOPD either. Investigating a subgroup of current smoker patients (n = 15), there was a significant correlation between the levels of eCO and blood carboxyhemoglobin concentrations both at exacerbation and discharge. No associations were found between eCO and lung function or blood gas parameters. Conclusion: Our results suggest that monitoring eCO during the treatment of AECOPD is of limited clinical value.

show abstract

Exhaled carbon monoxide

Ryter

2020

Breathborne Biomarkers and the Human Volatilome

View full text Add to dashboard Cite

Exhaled CO, a predictor of lung function?

Abstract: Inhalation and type of cigarette affects exhaled CO levels. CO measures have no predictive value regarding neither present lung function nor decline in lung function with time in a population survey setting.

Cited by 11 publications

References 21 publications

Does the Finding of Small Airway Obstruction in Pulmonary Function Tests Effect End-Expiratory Carbonmonoxide Level?

Does the Finding of Small Airway Obstruction in Pulmonary Function Tests Effect End-Expiratory Carbonmonoxide Level?

Assessment of exhaled carbon monoxide in exacerbations of chronic obstructive pulmonary disease

Exhaled carbon monoxide

Contact Info

Product

Resources

About