2018
DOI: 10.1111/evj.12979
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Exhaled breath condensate hydrogen peroxide, pH and leukotriene B4 are associated with lower airway inflammation and airway cytology in the horse

Abstract: EBC pH and H O concentrations are altered by airway inflammation, suggesting a role for these biomarkers in the diagnosis and monitoring of airway disease. Environmental and methodological factors can influence these biomarkers and should be considered in the interpretation of results.

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Cited by 6 publications
(4 citation statements)
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“…Finally, exhaled breath condensate is a promising source of biomarkers in human lung diseases. In horses, studies have investigated its use to diagnose lower airway inflammation and showed promising results for severe equine asthma but data for moderate equine asthma are still missing ( 80 ). Of note, evaluation of exhaled breath condensate can be difficult to set up on the field.…”
Section: Discussionmentioning
confidence: 99%
“…Finally, exhaled breath condensate is a promising source of biomarkers in human lung diseases. In horses, studies have investigated its use to diagnose lower airway inflammation and showed promising results for severe equine asthma but data for moderate equine asthma are still missing ( 80 ). Of note, evaluation of exhaled breath condensate can be difficult to set up on the field.…”
Section: Discussionmentioning
confidence: 99%
“…Exhaled breath condensate is a promising source of biomarkers of lung disease in humans. Exhaled breath condensate hydrogen peroxide concentration and pH were higher in horses with mild EA, vs. controls ( 69 ). Additionally, both hydrogen peroxide and pH had a positive association with BAL neutrophil percentage, while leukotriene B-4 demonstrated a positive association with BAL eosinophil percentage.…”
Section: Are Pertinent Biomarkers Of Equine Asthma Already Available mentioning
confidence: 99%
“…The existence of neutrophil extracellular traps (NETosis) in horses with severe EA presents an additional method to determine response to treatment ( 67 ), and recently the presence of degenerate neutrophils has been shown to raise suspicion for bacterial infection ( 68 ). The question of macrophage morphology as an indicator of inflammation is also an area that will profit from further investigation ( 69 ). Recently, as well, the paucigranulocytic phenotype has been described in which horses with clear signs of severe EA have low neutrophil percentages in the BAL ( 46 ).…”
Section: Recommended Minimum Database For Diagnosis Of Equine Asthma mentioning
confidence: 99%
“…This prospective, cross‐sectional study by Surita du Preez and colleagues in Australia aimed to characterise associations between biomarkers in exhaled breath condensate (EBC) and the cytological and endoscopic findings in horses with lower airway inflammation .…”
Section: Exhaled Breath Condensate Analysismentioning
confidence: 99%