Exhalation Delivery System: Novel Device for Nasal Polyps Treatment

Chu, Rebecca

doi:10.1089/ped.2019.1066

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…For patients with acute exacerbation of CRSwNP, it may be necessary to combine bi‐directional nasal drug delivery devices with other pharmacotherapies, including saline, antibiotics, and biologics 40 . It has also been reported that fluticasone propionate is effective and safe when administered to children via the breath‐powered bi‐directional delivery method 41 …”

Section: Discussionmentioning

confidence: 99%

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Bi‐directional nasal drug delivery systems: A scoping review of nasal particle deposition patterns and clinical application

Liu,

2023

Laryngoscope Investig Oto

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ObjectivesTo compare the deposition patterns within the nasal cavity between the bi‐directional and unilateral nasal delivery systems. And to summarize the clinical application of the bi‐directional nasal drug delivery devices.Data sourcePubMed, Cochrane Library, Embase, and Web of Science databases.MethodsA scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA). We included studies exploring patterns and influencing factors of particle depositions within the nasal cavity among patients, healthy controls, and nose cast models using the bi‐directional and unilateral nasal delivery system. The clinical application of the bi‐directional delivery devices was also summarized.ResultsA total of 24 studies were included in this review. Bi‐directional nasal delivery systems utilize forced exhalation to power the delivery of drugs to deeper areas of the nasal cavity and paranasal sinuses. Unilateral nasal delivery systems included traditional liquid spray pumps, the aerosol mask system, nebulization, and conventional nasal inhalation. Compared with unilateral delivery systems, the bi‐directional nasal delivery system provided a more extensive and efficient nasal deposition in the nasal cavity, especially in the olfactory cleft, without lung deposition. Several parameters, including particle size, pulsatile flow, and nasal geometry, could significantly influence nasal deposition. The bi‐directional nasal delivery system enables better delivery of steroids or sumatriptan to the sinonasal cavity's high and deep target sites. This bi‐directional delivery device demonstrated an effective and well‐tolerated treatment that produced high drug utilization, rapid absorption, and sustained symptom improvement among patients with chronic rhinosinusitis (CRS) or migraine.ConclusionThe bi‐directional nasal drug delivery systems demonstrated significantly higher drug deposition in superior and posterior regions of the nasal cavity than unilateral nasal delivery systems. Further studies should explore its potential role in delivering drugs to the olfactory cleft among patients with olfactory disorders and central nervous system diseases.Level of evidenceN/A.

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Section: Discussionmentioning

confidence: 99%

“… 40 It has also been reported that fluticasone propionate is effective and safe when administered to children via the breath‐powered bi‐directional delivery method. 41 …”

Section: Discussionmentioning

confidence: 99%

Bi‐directional nasal drug delivery systems: A scoping review of nasal particle deposition patterns and clinical application

Liu,

2023

Laryngoscope Investig Oto

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“…It has shown promising results in adults and is currently undergoing evaluation in pediatric patients. 186 Medical devices using energy fields for allergic rhinitis treatment…”

Section: Nasal Exhalation Delivery Systemsmentioning

confidence: 99%

“…It has shown promising results in adults and is currently undergoing evaluation in pediatric patients. 186 …”

Section: Devices Used For Treatmentmentioning

confidence: 99%

Medical devices in allergy practice

Popov

Passalacqua

González‐Díaz

et al. 2020

World Allergy Organization Journal

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Medical devices provide people with some health benefits in terms of diagnosis, prevention, treatment, and monitoring of disease processes. Different medical specialties use varieties of medical devices more or less specific for them. Allergology is an interdisciplinary field of medical science and teaches that allergic reactions are of systemic nature but can express themselves at the level of different organs across the life cycle of an individual. Subsequently, medical devices used in allergology could be regarded as: 1) general, servicing the integral diagnostic and management principles and features of allergology, and 2) organ specific, which are shared by organ specific disciplines like pulmonology, otorhinolaryngology, dermatology, and others. The present position paper of the World Allergy Organization (WAO) is meant to be the first integral document providing structured information on medical devices in allergology used in daily routine but also needed for sophisticated diagnostic purposes and modern disease management. It is supposed to contribute to the transformation of the health care system into integrated care pathways for interrelated comorbidities.

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Strategies for enhanced direct nose-to-brain drug delivery

Madav

Wairkar

2021

Direct Nose-to-Brain Drug Delivery

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Exhalation Delivery System: Novel Device for Nasal Polyps Treatment

Cited by 4 publications

References 13 publications

Bi‐directional nasal drug delivery systems: A scoping review of nasal particle deposition patterns and clinical application

Bi‐directional nasal drug delivery systems: A scoping review of nasal particle deposition patterns and clinical application

Medical devices in allergy practice

Strategies for enhanced direct nose-to-brain drug delivery

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