Exfoliative Cytology of a Lymphoepitheliomalike Carcinoma in a Cervical Smear

Reich, Olaf; Pickel, H; Pürstner, P.

doi:10.1159/000330995

Cited by 9 publications

(2 citation statements)

References 7 publications

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“…In addition, there was a lack of low grade atypia in the background squamous cells, as was also pointed out in prior reports. 7,8 Thus, we chose to classify the lesion as "atypical glandular cells," which we felt would provide the necessary clinical guidance to sample for both glandular (endometrial) and squamous lesions per ASCCP guidelines. Preparation of a cell block was also not deemed helpful, especially given the fact that p16…”

Section: Discussionmentioning

confidence: 99%

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Lymphoepithelioma‐like carcinoma of the uterine cervix: Cytomorphologic features and diagnostic pitfalls by liquid‐based cytology

Lloyd

Chadwick

2017

Diagnostic Cytopathology

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Lymphoepithelioma-like carcinoma (LELC) is a rare variant of cervical squamous cell carcinoma with unclear HPV and EBV association. Due to the accompanying and often obscuring lymphocytic inflammation, malignant cells may be difficult to recognize on cytologic samples and can mimic several more common benign and atypical cervical lesions. In this case report, we describe the cytomorphologic findings of LELC by liquid-based cytology in a 59-year-old Caucasian woman who was positive for high risk HPV but had no visible cervical lesions. We also discuss the differential diagnosis, diagnostic pitfalls, and practical considerations for diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…5 Likely due to its rare occurrence in the uterine cervix, the cytomorphologic features of this entity have only been described in a few case reports and not on liquid-based preparations. [6][7][8] We present the following case to further describe the cytomorphologic features of this neoplasm as well as illustrate pitfalls associated with its diagnosis.…”

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confidence: 99%

Lymphoepithelioma‐like carcinoma of the uterine cervix: Cytomorphologic features and diagnostic pitfalls by liquid‐based cytology

Lloyd

Chadwick

2017

Diagnostic Cytopathology

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Lymphoepithelioma‐like carcinoma of cervix

Rathore

Arora

Singh

2016

Diagnostic Cytopathology

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Lymphoepithelioma-like carcinoma (LELC) is a rare neoplasm of the cervix. The importance of distinguishing this undifferentiated carcinoma with a predominant lymphocytic infiltrate lies in the fact that despite being poorly differentiated they have a better prognosis. The diagnosis however becomes more challenging when the pathologist is provided with a small cervical biopsy or a Papanicolaou smear. While the reports describing histology and their relation to Epstein-Barr virus (EBV) are many, there are only few case reports describing the cytology of these tumors. We describe the cytological features of LELC of cervix on conventional smear and correlate it with the histopathological findings of the same. A 67-year-old multiparous Hindu woman presented to the gynecology outpatient department with the history of postmenopausal bleeding for the past six months. The cytological examination of the cervical smear (Papanicolaou stain) was done followed by cervical and endometrial biopsy. Based on Papanicolaou smear and biopsy suggestive of a poorly differentiated carcinoma a radical hysterectomy with pelvic lymphadenectomy was performed. Hysterectomy specimen showed the morphology of LELC and was then correlated with the cervical smears retrospectively. On review of cytological smears it was seen that the tumor cell clusters had an abundant lymphoid background, which was overlooked earlier. Immunohistochemistry for EBV was negative. We conclude that the presence of undifferentiated tumor cell clusters with ill-defined cell borders and large number of lymphoid cells in the background suggest the diagnosis of LELC on cervical cytology. Diagn. Cytopathol. 2017;45:239-242. © 2016 Wiley Periodicals, Inc.

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Cervical squamous cell carcinoma

Zhang¹,

Robboy²

2009

Robboy's Pathology of the Female Reproductive Tract

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Exfoliative Cytology of a Lymphoepitheliomalike Carcinoma in a Cervical Smear

Cited by 9 publications

References 7 publications

Lymphoepithelioma‐like carcinoma of the uterine cervix: Cytomorphologic features and diagnostic pitfalls by liquid‐based cytology

Lymphoepithelioma‐like carcinoma of the uterine cervix: Cytomorphologic features and diagnostic pitfalls by liquid‐based cytology

Lymphoepithelioma‐like carcinoma of cervix

Cervical squamous cell carcinoma

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