Lymphoepithelioma‐like carcinoma of cervix

Abstract

Lymphoepithelioma-like carcinoma (LELC) is a rare neoplasm of the cervix. The importance of distinguishing this undifferentiated carcinoma with a predominant lymphocytic infiltrate lies in the fact that despite being poorly differentiated they have a better prognosis. The diagnosis however becomes more challenging when the pathologist is provided with a small cervical biopsy or a Papanicolaou smear. While the reports describing histology and their relation to Epstein-Barr virus (EBV) are many, there are only few case reports describing the cytology of these tumors. We describe the cytological features of LELC of cervix on conventional smear and correlate it with the histopathological findings of the same. A 67-year-old multiparous Hindu woman presented to the gynecology outpatient department with the history of postmenopausal bleeding for the past six months. The cytological examination of the cervical smear (Papanicolaou stain) was done followed by cervical and endometrial biopsy. Based on Papanicolaou smear and biopsy suggestive of a poorly differentiated carcinoma a radical hysterectomy with pelvic lymphadenectomy was performed. Hysterectomy specimen showed the morphology of LELC and was then correlated with the cervical smears retrospectively. On review of cytological smears it was seen that the tumor cell clusters had an abundant lymphoid background, which was overlooked earlier. Immunohistochemistry for EBV was negative. We conclude that the presence of undifferentiated tumor cell clusters with ill-defined cell borders and large number of lymphoid cells in the background suggest the diagnosis of LELC on cervical cytology. Diagn. Cytopathol. 2017;45:239-242. © 2016 Wiley Periodicals, Inc.

Undifferentiated Lymphoepithelial Carcinoma of Cervix: A Rare Case Report

“…But its role in the western population seems less likely. In contrast, Chao et al in 2009 suggested that human papilloma virus (HPV) and not EBV is involved in the carcinogenesis of LEC of the cervix and also that EBV sequences actually exist in the florid inflammatory stromal component of these tumors [6,7].…”

Carcinoma linfoepitelial de cuello uterino con recurrencia a distancia

“…Puede presentarse desde una lesión cervical no visible hasta una masa cervical exofítica. La etiología del linfoepitelioma de cérvix es incierta 6 , su asociación con el virus de Epstein-Bar (EBV) y el virus del papiloma humano (VPH) es controversial 1 , por lo Figura 3. Las células tumorales muestran alto índice mitótico.…”

EBV-associated lymphoepithelioma-like thyroid carcinoma with favorable outcome: case report with cytopathologic and histopathologic study

“…EBV-associated thyroid carcinomas are seldom reported to have originated in the thyroid [ 9 ]. A favorable prognosis has been proposed in EBV-associated LELCs arising in the stomach, lung, liver, urinary bladder, salivary gland, and uterine cervix [ 10 – 15 ]. Regarding the thyroid, the behavior of EBV-related LELC has seldom been documented.…”