Exfoliation syndrome: prevalence and inheritance in a subisolate of the Finnish population

Abstract

In this population-based family study, ES is consistent with an autosomal dominant trait with incomplete penetrance, where the penetrance is more reduced in males than in females. However, the presence of ES was a greater risk factor for developing glaucoma in males than in females.

Update on pseudoexfoliation syndrome pathogenesis and associations with intraocular pressure, glaucoma and systemic diseases

“…The involvement of genetic factors in the pathogenesis of PEX was initially supported by evidence of strong familial aggregation [19,20]. However, a simple inheritance model has not been identified, which suggests a complex inheritance pattern resulting from interplay of multiple genetic and environmental factors [21].…”

Replication of a Glaucoma Candidate Gene on 5q22.1 for Intraocular Pressure in Mongolian Populations: The GENDISCAN Project

“…The heritability of IOP was 0.48, which is higher than that in other studies. 11,12,48 The higher heritability is most likely due, at least in part, to the lesser variation in other environments and more genetic heterogeneity underlying IOP levels.…”

The Prevalence of Pseudoexfoliation and the Long-term Changes in Eyes With Pseudoexfoliation in a South Indian Population

“…Another possible reason for the variation is that the minimum age of the study population varied from 40 to 60 years. [10][11][12][13][14][15][16][19][20][21][22][23][24]27,28 As age is a constant risk factor for PEX, this can explain some of the differences reported. Despite these differences, there do appear to be racial, genetic, or geographic factors that impact prevalence.…”

“…7,8 The prevalence of PEX has been reported from different populations [9][10][11][12][13][14][15][16][17][18][19][20] and is known to be high in Scandinavian countries and Greece. [21][22][23][24][25][26] Cross-sectional population-based studies have reported the prevalence of PEX in the Indian population and it varied from 2% to 6% in subjects aged 40 years and older. [27][28][29][30] Older age was found to be a significant risk factor.…”