No abstract

The findings support evidence that IOP regulation is associated with the 5q22.1 region, along with four other candidate regions. The present results further indicate that genetic factors regulating IOP in the general Mongolian population are linked to regions harboring POAG genes, suggesting that common genetic factors influence both normal IOP variation and POAG occurrence. In addition, the replication of previous findings concerning POAG regions from the white and African populations implies that the mutations regulating IOP levels did not occur recently.

rs4939827, rs4779584, and rs10795668 may contribute to the risk of CRC in the Korean population as well as in European populations. Novel rs17051076 could be associated with microsatellite instability-high CRC in Koreans. These associations support the ethnic diversity of CRC-susceptibility SNPs and should be taken into account in large-scale studies.