Exertional periodic breathing potentiates erythrocyte rheological dysfunction by elevating pro-inflammatory status in patients with anemic heart failure

Fu, Tieh‐Cheng; Wang, Chao-Hung; Chou, Szu-Ling; Liu, Min-Hui; Cherng, Wen‐Jin

doi:10.1016/j.ijcard.2012.03.170

Cited by 15 publications

(17 citation statements)

References 30 publications

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“…In results concerning the clinical definition however, a split analysis was integrated. The numbers for gender presented in Tables 3 and 4 of this article are correct as we received also an acknowledgement of the original authors [9,15,24]. The medians of peak VO 2 were 12.7 and 16.1 ml/kg/min respectively (Table 5).…”

Section: Resultsmentioning

confidence: 90%

“…The overall incidence of EOV amounted between 7% and 51% [22,27]. The population enrolment in the studies ranged from 17 to 119 months [9,24]. The follow-up range was between 3 and 46 months [26,28].…”

Section: Resultsmentioning

confidence: 99%

“…The meta-analysis results of the effect of EOV on peak VO 2 were described in 18 studies [9,15,[17][18][19]22,24,[26][27][28][29][30][31][32][33][34][35][36] . The overall random weighted estimate was − 2.91 ml/kg/min (95% CI: − 3.49 to − 2.32; p b 0.001).…”

Section: Resultsmentioning

confidence: 99%

“…The meta-analysis results of the effect of EOV on peak PETCO 2 were described in six studies [9,15,24,27,30,33]. The overall random weighted estimate was − 0.56 mm Hg (95% CI: − 0.75 to − 0.37, p b 0.001).…”

Section: Resultsmentioning

confidence: 99%

“…Expert opinions and recommendations on on-going studies or other relevant data were gathered. The corresponding author of a study was contacted if needed to obtain any missing information or data [9,17,[22][23][24]. If authors could not be reached [25] or if the data were no longer available, the trial was not included in this study.…”

Section: Methodsmentioning

confidence: 99%

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Prognostic respiratory parameters in heart failure patients with and without exercise oscillatory ventilation — A systematic review and descriptive meta-analysis

Cornelis

Taeymans

Hens

et al. 2015

International Journal of Cardiology

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The purpose of this review was to describe the occurrence of prognostic variables as derived from cardiopulmonary exercise testing (CPET) in patients with heart failure (HF), presenting exercise oscillatory ventilation (EOV) compared to patients without EOV. The effect of EOV on peak oxygen consumption (VO2), minute ventilation/carbon dioxide production (VE/VCO2) slope, oxygen uptake efficiency slope (OUES), rest and peak pulmonary end-tidal carbon dioxide pressure (PETCO2) was meta-analysed. A systematic search strategy was performed in five databases (Pubmed, Cochrane Library, PEDro, Science Direct and Web of Science) assessing 252 articles for eligibility. Nineteen citations met the inclusion criteria totalling 3032 patients with HF (EOV=1111; non-EOV=1921). The risk of bias was assessed by two researchers. Extracted data were pooled using random or fixed effects meta-analysis, if appropriate. The level of significance was set at p≤0.05. Overall, the presentation of EOV significantly indicated aggravated prognostic markers. Subgroup analysis revealed left ventricular ejection fraction (LVEF) and mode of CPET protocol as independent factors, whereas defining EOV significantly influenced the results. A meta-analysis of studies reporting hazard ratios for cardiovascular events demonstrated that HF patients with EOV run a fourfold risk for an adverse event compared to HF patients without EOV. In general, these findings suggest that the presence of EOV in patients with HF is associated with a deterioration of the prognostic CPET parameters. Furthermore, EOV can occur in HF patients with reduced as well as preserved ejection fraction. Further research on defining and assessing EOV in a more accurate and reproducible way is required.

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Section: Resultsmentioning

confidence: 90%