Anemia, heart failure and exercise training

Wang, Jong-Shyan

doi:10.1016/j.ijcard.2012.11.024

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…Under isovolumic exercise regimens on a bicycle ergometer, 5 wk of cycling AIT efficiently enhanced the capacity for O 2 delivery and utilization during exercise, as indicated by higher levels of pulmonary ventilation and tissue O 2 consumption at peak performance, compared to cycling MCT. Additionally, the current investigation, including previous and present works, revealed that the AIT regimen i) increased perfusion and O 2 extraction in skeletal muscles or cerebral tissues and ii) depressed the aggregation but enhanced the deformability of erythrocytes under shear flow in healthy individuals or patients with cardiovascular disease (10,28,30). A recent metaanalysis by Romain et al (19) showed that regular exercise significantly decreased blood viscosity and erythrocyte aggregation.…”

Section: Discussionsupporting

confidence: 58%

“…Moreover, alternating aerobic and anaerobic metabolic responses caused by AIT may serve as preconditioning to hypoxic stress, which may increase resistance to hypoxia-induced physiological dysfunction (4,32). Recent studies further demonstrated that cycling AIT significantly improved O 2 uptake efficiency by enhancing hemodynamic response to exercise and by suppressing oxidative stress/inflammation associated with cardiac dysfunction in patients with heart failure (10,28,30). However, no study has investigated the distinct effects of cycling interval and continuous exercise regimens on the rheological characteristics and band 3 activity of erythrocytes under hypoxic conditions.…”

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confidence: 99%

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Cycling Exercise Training Alleviates Hypoxia-Impaired Erythrocyte Rheology

Chou

Huang

Fu³

et al. 2016

Medicine &Amp; Science in Sports &Amp; Exercise

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Section: Discussionsupporting

confidence: 58%

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confidence: 99%

Cycling Exercise Training Alleviates Hypoxia-Impaired Erythrocyte Rheology

Chou

Huang

Fu³

et al. 2016

Medicine &Amp; Science in Sports &Amp; Exercise

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“…Lower hemoglobin (Hb) levels may reduce the carrying capacity of oxygen to tissues and result in higher rates of organ dysfunction, including heart failure and inflammatory diseases. [11][12][13][14][15] However, the effect of Hb levels on the development of BPD has not been explored before. Therefore, we designed the study to compare Hb levels in the first 3 days of life between BPD patients and non-BPD patients and determine whether lower Hb levels might increase the risk of developing BPD.…”

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confidence: 99%

Association between Hemoglobin Levels in the First 3 Days of Life and Bronchopulmonary Dysplasia in Preterm Infants

Duan

Kong

et al. 2016

Amer J Perinatol

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Objective The objective of this study was to determine the association between hemoglobin (Hb) levels in the first 3 days of life and bronchopulmonary dysplasia (BPD) in preterm infants. Study Design The study population comprises 147 neonates with a gestational age (GA) of less than 32 weeks who were admitted to BaYi Children's Hospital Affiliated to Beijing Military General Hospital from January 2014 to May 2015. Hb levels in the first 3 days of life, maternal and infant characteristics, were recorded and then analyzed. Results BPD patients had a lower GA and birth weight than non-BPD patients. Rates of surfactant use, use of early inhalation hormone, days of mechanical ventilation > 2 weeks, and patent ductus arteriosus in BPD patients were higher and have a significant difference. Number of transfusions was higher in BPD patients. Lower Hb levels in the first 3 days of life were also observed in BPD patients. A cutoff value of Hb levels was determined as 155.5 g/L. Hb ≤ 155 g/L in the first 3 days of life was a significant risk factor for BPD. Conclusion Our study demonstrated that lower Hb levels in the first 3 days of life may increase the risk of developing BPD in preterm infants.

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High-Intensity Interval Training Improves Erythrocyte Osmotic Deformability

Huang

Hsu

2019

Medicine &Amp; Science in Sports &Amp; Exercise

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Introduction Physical exercise or hypoxic exposure influences erythrocyte susceptibility to osmotic stress, and the aquaporin 1 (AQP1) facilitates the transport of water in erythrocytes. This study investigated whether high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) affect erythrocyte osmotic deformability by modulating AQP1 function under hypoxic stress. Methods Forty-five healthy sedentary males were randomized to engage in either HIIT (3-min intervals at 40% and 80% V˙O2 reserve, n = 15) or MICT (sustained 60% V˙O2 reserve, n = 15) on a bicycle ergometer for 30 min·d−1, 5 d·wk−1 for 6 wk, or to a control group that did not perform any exercise (n = 15). All subjects were analyzed with osmotic gradient ektacytometry for assessing erythrocyte membrane stability and osmotic deformability after hypoxic exercise (HE) (100 W under 12%O2 for 30 min). Results Before the intervention, HE increased the shear stress at 50% of maximal elongation (SS1/2) and the ratio of SS1/2 to maximal elongation index (SS1/2/EImax) on erythrocytes pretreated with 50 Pa of shear stress for 30 min and diminished HgCl2-depressed osmolality at 50%EImax (Ohyper). However, both HIIT and MICT for 6 wk diminished the elevations of erythrocyte SS1/2 and SS1/2/EImax caused by HE. Moreover, HIIT also increased contents of erythrocyte AQP1 proteins while enhancing HgCl2-depressed Ohyper and area under elongation index–osmolarity curve after HE. Additionally, changes in erythrocyte AQP1 contents were associated with changes in HgCl2-depressed erythrocyte Ohyper and area under elongation index–osmolarity curve. Conclusions Acute HE reduces erythrocyte membrane stability, whereas either HIIT or MICT attenuates the depression of erythrocyte membrane stability by HE. Moreover, HIIT increases the AQP1 content and facilitates the HgCl2-mediated osmotic deformability of erythrocytes after HE.

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Anemia, heart failure and exercise training

Cited by 3 publications

References 19 publications

Cycling Exercise Training Alleviates Hypoxia-Impaired Erythrocyte Rheology

Cycling Exercise Training Alleviates Hypoxia-Impaired Erythrocyte Rheology

Association between Hemoglobin Levels in the First 3 Days of Life and Bronchopulmonary Dysplasia in Preterm Infants

High-Intensity Interval Training Improves Erythrocyte Osmotic Deformability

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