High-Intensity Interval Training Improves Erythrocyte Osmotic Deformability

Huang, Yu-Chieh; Hsu, Chih‐Chin

doi:10.1249/mss.0000000000001923

Cited by 12 publications

(28 citation statements)

References 34 publications

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“…These changes were associated with improved function, as indicated by an increase in deformability and a decrease in the tendency to aggregate ( Figure 5). Similar alterations with a concomitant increase in function, indicating a shift towards an overall younger RBC population, have been reported to result from various forms of exercise [10,[26][27][28][29].…”

Section: Discussionsupporting

confidence: 74%

Red Blood Cell Aging as a Homeostatic Response to Exercise-Induced Stress

et al. 2019

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Our knowledge on the molecular mechanisms of red blood cell aging is mostly derived from in vitro studies. The Four Days Marches of Nijmegen in the Netherlands, the world’s largest yearly walking event, constitutes a unique possibility to study the effect of mechanical and biochemical stressors occurring during moderate-intensity exercise on red blood cell aging in vivo. Therefore, longitudinal measurements were performed of biophysical, immunological, and functional red blood cell characteristics that are known to change during aging. Our data show that moderate-intensity exercise induces the generation of a functionally improved red blood cell population with a higher deformability and a decreased tendency to aggregate. This is likely to be associated with an early removal of the oldest red blood cells from the circulation, as deduced from the (dis)appearance of removal signals. Thus, the physiological red blood cell aging process maintains homeostasis in times of moderate-intensity exercise-induced stress, probably by accelerated aging and subsequent removal of the oldest, most vulnerable red blood cells.

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Section: Discussionsupporting

confidence: 74%

Red Blood Cell Aging as a Homeostatic Response to Exercise-Induced Stress

et al. 2019

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“…In this regard, the physiological implications of this alternative pathway for oxygen diffusion suggest that AQP1 may facilitate oxygen diffusion in particular membranes (Clanton et al, 2013). Thus, AQP1 expression in erythrocytes may not only be associated with osmotic control (Huang Y.C. et al, 2019), but also oxygen diffusion.…”

Section: Sterols In Membranes During Evolution: Oxygen As the Evolutimentioning

confidence: 99%

“…AQP1 may be a means in red blood cells to overcome the limitation imposed by the high membrane cholesterol content (50 mol%) (Steinbach et al, 1974; Menchaca et al, 1998; Buchwald et al, 2000a; Dotson et al, 2017). AQP1 expression is related to high oxygen [and other gases like CO 2 (Blank and Ehmke, 2003)] diffusion especially in high demand tissues like lung, carotid body, erythrocytes and microvasculature endothelial cells (Borok and Verkman, 2002; Echevarría et al, 2007; Munoz-Cabello et al, 2010; Abreu-Rodriguez et al, 2011; Crisp et al, 2016; Huang Y.C. et al, 2019).…”

Section: Sterols In Membranes During Evolution: Oxygen As the Evolutimentioning

confidence: 99%

The Evolution of Cholesterol-Rich Membrane in Oxygen Adaption: The Respiratory System as a Model

Zuniga-Hertz

Patel

2019

Front. Physiol.

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The increase in atmospheric oxygen levels imposed significant environmental pressure on primitive organisms concerning intracellular oxygen concentration management. Evidence suggests the rise of cholesterol, a key molecule for cellular membrane organization, as a cellular strategy to restrain free oxygen diffusion under the new environmental conditions. During evolution and the increase in organismal complexity, cholesterol played a pivotal role in the establishment of novel and more complex functions associated with lipid membranes. Of these, caveolae, cholesterol-rich membrane domains, are signaling hubs that regulate important in situ functions. Evolution resulted in complex respiratory systems and molecular response mechanisms that ensure responses to critical events such as hypoxia facilitated oxygen diffusion and transport in complex organisms. Caveolae have been structurally and functionally associated with respiratory systems and oxygen diffusion control through their relationship with molecular response systems like hypoxia-inducible factors (HIF), and particularly as a membrane-localized oxygen sensor, controlling oxygen diffusion balanced with cellular physiological requirements. This review will focus on membrane adaptations that contribute to regulating oxygen in living systems.

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“…V O 2 R in our previous study using healthy sedentary males (Huang et al, 2019). With respect to underlying mechanisms of the SCT effects on erythrocyte rheological functions remain unclear, further investigations need to be undertaken.…”

Section: Discussionmentioning

confidence: 88%

“…Moreover, osmolality-mediated erythrocyte deformability plays a meaningful role in hemorheology during exercise ( Baskurt and Meiselman, 2003 ). In our recent study of healthy sedentary males, cycling training at 60% of

O 2 reserve (

O 2 R) improved the erythrocyte membrane stability and osmotic deformability ( Huang et al, 2019 ). However, aerobic exercise effects on erythrocyte membrane stability and osmotic deformability in PAD patients have not yet been established.…”

Section: Introductionmentioning

confidence: 99%

Supervised Cycling Training Improves Erythrocyte Rheology in Individuals With Peripheral Arterial Disease

Hsu

Lin

et al. 2022

Front. Physiol.

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Peripheral arterial disease (PAD) results in insufficient flow to lower extremities. Aerobic exercise provides health benefits for individuals with PAD, but basic science behind it is still debated. Twenty-one PAD patients aged about 70 years with female/male as 7/14 were recruited. Among them, 11 were randomized to have supervised cycling training (SCT) and 10 to receive general healthcare (GHC) as controls. SCT participants completed 36 sessions of SCT at the first ventilation threshold within 12 weeks and the controls received GHC for 12 weeks. Ankle-brachial index (ABI), 6-min walk test (6MWT), peak oxygen consumption (V˙O2peak), minute ventilation (V˙E), minute carbon dioxide production (V˙CO2), erythrocyte rheology, including the maximal elongation index (EImax) and shear stress at 50% of maximal elongation (SS1/2), and the Short Form-36 (SF-36) questionnaire for quality of life (QoL) were assessed before and 12 weeks after initial visit. SCT significantly decreased the SS1/2 as well as SS1/2 to EImax ratio (SS1/2/EImax) and increased the erythrocyte osmolality in the hypertonic region as well as the area under EI-osmolality curve. The supervised exercise-induced improvement of erythrocyte deformability could contribute to the increased peripheral tissue O2 delivery and was possibly related with increased V˙O2peak. The physiological benefit was associated with significantly increased ABI, 6-min walking distance, cardiorespiratory fitness, and SF-36 score. However, no significant changes in aerobic capacity and erythrocyte rheological properties were observed after 12-week of GHC. In conclusion, SCT improves aerobic capacity by enhancing erythrocyte membrane deformability and consequently promotes QoL in PAD patients.

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High-Intensity Interval Training Improves Erythrocyte Osmotic Deformability

Cited by 12 publications

References 34 publications

Red Blood Cell Aging as a Homeostatic Response to Exercise-Induced Stress

Red Blood Cell Aging as a Homeostatic Response to Exercise-Induced Stress

The Evolution of Cholesterol-Rich Membrane in Oxygen Adaption: The Respiratory System as a Model

Supervised Cycling Training Improves Erythrocyte Rheology in Individuals With Peripheral Arterial Disease

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