Exérèse de phéochromocytomes par cœliochirurgie. Effet du blocage périopératoire par lˈurapidil

Effects of perioperative α 1 block on haemodynamic control during laparoscopic surgery for phaeochromocytoma

“…11 We have previously shown that perioperative infusion of urapidil may be effective in controlling intraoperative hypertension in these patients. 12 The aim of this prospective study was to con®rm the ef®cacy of perioperative i.v. urapidil by studying the relationship between plasma catecholamine levels and blood pressure during laparoscopic adrenalectomy for phaeochromocytoma.…”

Urapidil in the Preoperative Treatment of Pheochromocytomas: A Safe and Cost‐effective Method

“…The preoperative use of urapidil in PCC patients was first published by Tauzin‐Fin and colleagues in a study of 9 consecutive patients. All 9 patients in that study received urapidil prior to surgery for 3 days, a protocol similar to that followed for the patients presented in the present study [11]. Acute variations in blood pressure could be managed with additive drugs and none of these patients developed severe hyper‐ or hypotension during surgery.…”

“…Because orally administered phenoxybenzamine has an elimination half-life of 24 h, several series and case reports have examined the potential intravenous use of the selective a 1 -receptor antagonist urapidil for pretreatment in patients undergoing surgery for PCC, as urapidil reveals a significantly shorter elimination half-life of 2-4.8 h [10][11][12].…”

Préparation et environnement périopératoire dans la chirurgie du phéochromocytome

“…Grâce à un phénomène de « down régulation », plus ou moins marqué selon l'imprégna-tion préalable en catécholamines, l'intensité de la réponse clinique peut varier d'un individu à l'autre. Sur une série de neuf patients, Tauzin-Fin et al, [18] rapportent le profil de sécrétion rencontré le plus souvent au cours de ce type de chirurgie (Tableau 1).…”

“…Catécholamines : évolution peropératoire[18] n = 9 ; Médiane. Valeurs normales pg/ml : Na < 510, A < 170.…”