Exercise Training Potentiates The Cardioprotective Effects of Stem Cells Post-infarction

Vieira, Stella Sousa; Antônio, Ednei Luiz; Melo, Brunno Lemes de; Portes, Leslie Andrews; Montemor, Jairo; Oliveira, Helenita Antônia de; Martins, Flavia L; Zogbi, Camila; Girardi, Adriana C. C.; Silva, José Antônio da; Carvalho, Paulo de Tarso Camillo de; Tucci, Paulo José Ferreira; Serra, Andrey Jorge

doi:10.1016/j.hlc.2017.11.005

Cited by 8 publications

(4 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The surgical procedure to induce chronic infection was performed according to a well-established technique 4,5,26 . Under anesthesia and artificial ventilation 155 with a Harvard Rodent Ventilator (Model 863; Harvard Apparatus, Holliston, MA), a left thoracotomy was performed to externalize the heart, and the coronary artery ligated with 6-0 polypropylene.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Photobiomodulation therapy combined with carvedilol attenuates post-infarction heart failure by suppressing excessive inflammation and oxidative stress in rats

Grandinetti

Carlos

Antônio

et al. 2019

Sci Rep

Self Cite

View full text Add to dashboard Cite

The post-myocardial infarction heart failure (HF) still carries a huge burden since current therapy is unsuccessful to abrogate poor prognosis. Thus, new approaches are needed, and photobiomodulation therapy (PBMt) may be a way. However, it is not known whether PBMt added to a standard HF therapy provides additional improvement in cardiac remodeling in infarcted rats. This study sought to determine the combined carvedilol-drug and PBMt with low-level laser therapy value in HF. Rats with large infarcts were treated for 30 days. The functional fitness was evaluated using a motorized treadmill. Echocardiography and hemodynamic measurements were used for functional evaluations of left ventricular (LV). ELISA, Western blot and biochemical assays were used to evaluate inflammation and oxidative stress in the myocardium. Carvedilol and PBMt had a similar action in normalizing pulmonary congestion and LV end-diastolic pressure, attenuating LV dilation, and improving LV systolic function. Moreover, the application of PBMt to carvedilol-treated rats inhibited myocardial hypertrophy and improved +dP/dt of LV. PBMt alone prevented inflammation with a superior effect than carvedilol. Carvedilol and PBMt normalized 4-hydroxynonenal (a lipoperoxidation marker) levels in the myocardium. However, importantly, the addition of PBMt to carvedilol attenuated oxidized protein content and triggered a high activity of the anti-oxidant catalase enzyme. In conclusion, these data show that the use of PBMt plus carvedilol therapy results in a significant additional improvement in HF in a rat model of myocardial infarction. These beneficial effects were observed to be due, at least in part, to decreased myocardial inflammation and oxidative stress.

show abstract

Section: Methodsmentioning

confidence: 99%

“…Functional fitness was evaluated on the 7th and 29th day of the study by using a motorized treadmill 26 . Each rat underwent a 2-minute warm-up period at 25 cm/s, following which the running speed was increased by 9 cm/s every 2 min till the rats were exhausted.…”

Section: Methodsmentioning

confidence: 99%

Photobiomodulation therapy combined with carvedilol attenuates post-infarction heart failure by suppressing excessive inflammation and oxidative stress in rats

Grandinetti

Carlos

Antônio

et al. 2019

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, in a novel way, it has been described that PE induces a pro-angiogenic medium that can increase the therapeutic effects of stem cells derived from adipose tissue in cardiac remodeling after myocardial infarction [21], so its potential in genetic medicine, it is promising and can contribute to generating favorable tissue environments for cell insertion and even in organ transplants.…”

Section: About the Cardiovascular Systemmentioning

confidence: 99%

Ischemic Preconditioning in Cardiac and Skeletal Muscle Induced by Exercise

Sampieri-Cabrera¹,

Lopez‐Toledo²,

Aceves-Hernández³

et al. 2020

Cardiorespiratory Fitness

View full text Add to dashboard Cite

Since it was discovered, ischemic preconditioning (IPC) has motivated research groups around the world to develop preconditioning protocols capable of protecting tissues against prolonged insults. In 31 years of study, promising results have been obtained on the beneficial role of the CPI and the mechanisms involved in its regulation. Also, different preconditioning protocols that have obtained results similar to the classic CPI have been developed, among which is the exercise-induced preconditioning (EP), that has been proven to protect the heart against an insult, mitigate the atrophy of the heart muscle and increase physical performance in athletes and/or athletes.

show abstract

“…Mesenchymal stem cells (MSCs) are widely used in several diseases, such as osteoarthritis, osteogenesis imperfecta, articular cartilage defects, and bone fracture (1–4). Results from our research group illustrate that the MSCs therapy increased myocardial vascularization, prevented infarct expansion, and attenuated cardiac dysfunction in rats with heart failure (3–6).…”

Section: Introductionmentioning

confidence: 99%

Light‐emitting Diode Can Enhance the Metabolism and Paracrine Action of Mesenchymal Stem Cells

Mansano

Rocha

Teixeira

et al. 2023

Photochem & Photobiology

Self Cite

View full text Add to dashboard Cite

This study investigated the influence of red light‐emitting diodes (LED, 630 nm) on different irradiation parameters and the number of applications on mesenchymal stem cells derived from adipose tissue (AdMSCs) metabolism and paracrine factors. The AdMSCs were irradiated with a LEDbox device (output power: 2452.5 mW; laser beam: 163.5 cm2; irradiance: 15 mW cm−2) using radiant exposures of 0.5, 2, and 4 J cm−2, respectively. AdMSCs were irradiated once or every 48 h up to three irradiations. All molecular analyses were performed 24 h after the last irradiation. LED did not induce changes in cell count, DNA damage, and oxidative stress. A significant repercussion of the LED has been noticed after three irradiations with 4 J cm−2. AdMSCs had higher levels of IL‐6, IGF‐1, and NOx index. A higher ATP content and MMT/Resazurin assay were identified in AdMSCs irradiated three times with 4 J cm−2. Mitochondrial basal respiration, maximal respiration and proton leak under metabolic stress were reduced by 0.5 and 2 J cm−2 irradiations. These data showed that three LED irradiations with 4 J cm−2 may be a suitable parameter for future AdMSCs therapy because of its improved metabolic activity, ATP content, and IL‐6, IGF‐1, and nitric oxide secretion.

show abstract

Exercise Training Potentiates The Cardioprotective Effects of Stem Cells Post-infarction

Cited by 8 publications

References 45 publications

Photobiomodulation therapy combined with carvedilol attenuates post-infarction heart failure by suppressing excessive inflammation and oxidative stress in rats

Photobiomodulation therapy combined with carvedilol attenuates post-infarction heart failure by suppressing excessive inflammation and oxidative stress in rats

Ischemic Preconditioning in Cardiac and Skeletal Muscle Induced by Exercise

Light‐emitting Diode Can Enhance the Metabolism and Paracrine Action of Mesenchymal Stem Cells

Contact Info

Product

Resources

About