Exercise training improves the IL-10/TNF-α cytokine balance in the gastrocnemius of rats with heart failure

Calegari, Leonardo; Nunes, Ramiro Barcos; Mozzaquattro, Bruna B.; Rossato, Douglas Dalcin; Lago, Pedro Dal

doi:10.1016/j.bjpt.2017.09.004

Cited by 22 publications

(11 citation statements)

References 34 publications

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“…In addition to IL-6, other myokines may also have different kinds of anti-inflammatory cytokine properties. It has been shown that long-term exercise can increase the production and secretion of IL-10 in the skeletal muscles [38]. In a peripheral nerve injury mouse model, two weeks of low-intensity exercise was found to inhibit peripheral and central neuroinflammatory responses via upregulation of IL-4 [37].…”

Section: Exercise Regulates Microglial Activation By Increasing Anmentioning

confidence: 99%

Physical Exercise Inhibits Inflammation and Microglial Activation

Mee-inta

Zhao

Kuo

2019

Cells

167

126

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Accumulating evidence indicates that exercise can enhance brain function and attenuate neurodegeneration. Besides improving neuroplasticity by altering the synaptic structure and function in various brain regions, exercise also modulates multiple systems that are known to regulate neuroinflammation and glial activation. Activated microglia and several pro-inflammatory cytokines play active roles in the pathogenesis of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. The purpose of this review is to highlight the impacts of exercise on microglial activation. Possible mechanisms involved in exercise-modulated microglial activation are also discussed. Undoubtedly, more studies are needed in order to disclose the detailed mechanisms, but this approach offers therapeutic potential for improving the brain health of millions of aging people where pharmacological intervention has failed.

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Section: Exercise Regulates Microglial Activation By Increasing Anmentioning

confidence: 99%

Physical Exercise Inhibits Inflammation and Microglial Activation

Mee-inta

Zhao

Kuo

2019

Cells

167

126

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“…Thus, an increase of a number of NK cells during the PE-CATs interaction may be responsible for lowering inflammation and enhancing the immune system [3,4,17,18,138]. Furthermore, moderate-to-vigorous PE enhances the antioxidant defense via up-regulating resistance to OS, owing to the fact that moderate elevated concentrations of AD and NA increase concentrations of anti-inflammatory cytokine IL-10, interleukin-1-receptor (IL-1RA) and IGF-α [139,140]. The beneficial effect of training with moderate intensity for 6 months and 12 months on low-grade inflammation in overweight and/or obese women manifesting as decrease of leptin, resistin, and IL-6 has been confirmed [127].…”

Section: A C C E P T E Dmentioning

confidence: 99%

Physical exercise and catecholamines response: benefits and health risk: possible mechanisms

Kruk

Kotarska

Aboul‐Enein

2020

Free Radical Research

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Beneficial effect of regular moderate physical exercise (PE) and negative effect of severe exercise and/or overtraining as an activator of the sympathetic nervous system (SNS) have been shown in numerous aspects of human health, including reduced risk of cardiovascular disease, neurological disease, depression, and some types of cancer. Moderate-to-vigorous PE stimulates the SNS activation, releasing catecholamines (CATs) adrenaline, noradrenaline, dopamine that play an important regulatory and modulatory actions by affecting metabolic processes and the immune system. Summary of the dispersed literature in this area and explanation of the biological mechanisms operating between PE-CATs and the immune system would lead to a better understanding of the beneficial and negative effects of PE on health. This overview aimed to: demonstrate representative literature findings on the exercise released CATs levels, major functions performed by these hormones, their interactions with immune system and their effects on carbohydrate and lipid metabolism. Also, mechanisms of cytotoxic free radicals and reactive oxygen species generation during CATs oxidation, and molecular mechanisms of CATs response to exercise are discussed to demonstrate positive and negative on human health effects. Owing to the large body of the subject literature, we present a representative cross-section of the published studies in this area.The results show a significant role of CATs in carbohydrate and lipid metabolism, immunity and as generators of reactive oxygen species, depending on PE intensity and duration. Further investigation of the PE-CATs relationship should validate CATs levels to optimize safe intensity and duration of exercise and individualize their prescription, considering CATs to be applied as markers for a dose of exercise. Also, a better understanding of the biological mechanisms is also needed.

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“…Aerobic training associated with an acute myocardial infarction is also responsible for an increase in GLUT4 33 expression and increased serum levels of netrin-1, myocardial netrin-1 and DCC receptor, reduced the expression of myocardial proteins MMP2 and MMP9, to improving the degree of fibrosis after myocardial infarction in rats 34 , and also not only attenuates the level of TNF-α, but also improves the level of cytokine IL-10 in the skeletal muscle of rats with heart failure 35 .…”

Section: Signaling Paths Activated By Physical Exercisementioning

confidence: 99%

Efeitos do exercício físico na prevenção e tratamento de lesões por isquemia: uma revisão de literatura

Costa

Silva

Macedo

et al. 2020

Rev. Med. (São Paulo)

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Introdução: Em 2013 mais de 17,3 milhões de mortes/ano foram causadas por doenças cardiovasculares, acompanhado de uma estimativa de mais de 23,6 milhões de mortes para 2030, representando a maior causa global de morte. Objetivo: Esta revisão de literatura tem como objetivo a sistematização do conhecimento acerca dos efeitos do exercício físico como medida de prevenção e/ou tratamento em lesões causadas por isquemia, a fim de instigar novas pesquisas e contribuir para a disseminação de informação atual. Metodologia: Este estudo constitui uma revisão bibliográfica de caráter analítico dos estudos a respeito dos efeitos do exercício físico como medida de prevenção e tratamento de lesões causados por isquemia nos tecidos de animais submetidos a experimentação científica, em que foram coletados 99 artigos a partir de uma busca nas bases de dados Pubmed, SciELO e Lilacs com os descritores: “ischemia”, “exercise”, “rats” e “muscle”. Resultados e Conclusão: A atual literatura aponta para um consenso acerca dos efeitos cardioprotetores e neuroprotetores do atividade física, com ênfase no aumento da resistência contra agentes oxidantes, melhoria no processo de angiogênese, maior resistência contra acidificação do meio, melhoria no processo de cardiomiogênese, e apresenta as vias de sinalização moleculares que possivelmente explicam os efeitos advindos do exercício físico nas suas mais diferentes intensidades.

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Exercise training improves the IL-10/TNF-α cytokine balance in the gastrocnemius of rats with heart failure

Abstract: HighlightsHF increases pro-inflammatory cytokines levels in gastrocnemius.Exercise training reverses the atrophy of gastrocnemius induced by HF.Exercise training increases IL-10 and decreases TNF-α level in gastrocnemius.

Cited by 22 publications

References 34 publications

Physical Exercise Inhibits Inflammation and Microglial Activation

Physical Exercise Inhibits Inflammation and Microglial Activation

Physical exercise and catecholamines response: benefits and health risk: possible mechanisms

Efeitos do exercício físico na prevenção e tratamento de lesões por isquemia: uma revisão de literatura

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