Exercise training for asbestos-related and other dust-related respiratory diseases: a randomised controlled trial

Abstract

BackgroundThe study aimed to determine the short and long-term effects of exercise training on exercise capacity and health-related quality of life (HRQoL) compared to usual care in people with dust-related pleural and interstitial respiratory diseases. No previous studies have specifically evaluated exercise training in this patient population.MethodsParticipants with a diagnosis of a dust-related respiratory disease including asbestosis and asbestos related pleural disease were recruited and randomised to an eight-week exercise training group (EG) or a control group (CG) of usual care. Six-minute walk distance (6MWD), St George’s Respiratory Questionnaire (SGRQ) and Chronic Respiratory Disease Questionnaire (CRQ) were measured at baseline, eight weeks and 26 weeks by an assessor blinded to group allocation.ResultsThirty-three of 35 male participants completed the study. Sixty-nine percent of participants had asbestos related pleural disease. At eight weeks, compared to the CG, the EG showed a significantly increased 6MWD (mean difference (95%CI)) 53 metres (32 to 74), improved SGRQ total score, -7 points (-13 to -1) and increased CRQ total score, 6.4 points (2.1 to 10.7). At 26 weeks significant between-group differences were maintained in 6MWD, 45 metres (17 to 73) and CRQ total score, 13.1 points (5.2 to 20.9).ConclusionExercise training improved short and long-term exercise capacity and HRQoL in people with dust-related pleural and interstitial respiratory diseases.Clinical trial registration numberANZCTR12608000147381. Date trial registered: 27.03.2008.

The evidence of benefits of exercise training in interstitial lung disease: a randomised controlled trial

“…Improvements achieved in those with asbestosis exceeded the MID for 6MWD,25 symptoms and HRQoL26 28 29 and were comparable to previous reports in a combined cohort of dust-related pleural and interstitial respiratory diseases 13. Participants with IPF experienced smaller gains, in accordance with previous investigations11 14 24 but improvements achieved fell within the MID range for 6MWD25 and exceeded the MID for HRQoL,26 28 suggesting that exercise training is equally effective in IPF.…”

Physical activity in people with asbestos related pleural disease and dust-related interstitial lung disease

“…Immediately following exercise training in a combined cohort of people with ARPD and dust-related ILD, PA levels increased. 27 However, the improvements in PA were very small in the longer term. The improvements in PA specific to either people with dust-related ILD or ARPD remain unknown.…”

Bedeutung von Depression und Angst im Krankheitsmanagement von pneumologischen Berufskrankheiten

“…In einer jüngsten Untersuchung von Dale et al [14] haben Patienten mit staubverursachten interstitiellen Lungenerkrankungen signifikant geringere Aktivitätslevel, gemessen anhand der Schritte pro Tag und des Energieverbrauchs, als Patienten mit asbestbedingten Pleuraveränderungen oder gleichaltrige gesunde Personen. Patienten mit Asbestose oder asbestbedingten Pleuraveränderungen profitieren in einer randomisierten kontrollierten Studie von einem 8-wöchigen Training hinsichtlich der körperlichen Leistungsfähigkeit und der körperlichen Aktivität sowie der Lebensqualität und der emotionalen Funktion im Anschluss des Programms sowie 26 Wochen danach [13].…”