Exercise training and detraining modify the morphological and mechanical properties of single cardiac myocytes obtained from spontaneously hypertensive rats

Carneiro‐Júnior, Miguel Araujo; Peluzio, M.C.G.; Silva, C H O; Amorim, Paulo Roberto dos Santos; Silva, K A; Souza, Matheus O.; Castro, Cynthia Aparecida de; Roman‐Campos, Danilo; Prímola-Gomes, Thales Nicolau; Natali, Antônio José

doi:10.1590/s0100-879x2010007500117

Cited by 18 publications

(14 citation statements)

References 19 publications

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“…In a different hypertension model, the 2K1C, Soares et al 7 compared the effect of exercise training with or without a 3% workload on different cardiac and renal parameters in renovascular hypertensive (2K1C) male Fisher rats. In contrast to what was described by Carneiro-Júnior et al 4 concentric left ventricle hypertrophy was prevented by exercise without a workload, with decreased myocyte diameter and vasculature thickness. Work loaded exercise further reduced concentric remodeling and prevented the increase in cardiac vasculature wall thickness, with decreased myocyte diameter and increased collagen deposition.…”

Section: Resultscontrasting

confidence: 93%

“…Carneiro-Júnior et al 4 determined the effects of exercise training and detraining on the morphological and mechanical properties of left ventricular myocytes in 4-month-old spontaneously hypertensive trained vs. sedentary rats and found that cell length was greater in trained vs. sedentary and remained so after detraining, whereas cell width and volume were unaffected by either exercise training or detraining. They conclude that exercise affected left ventricle remodeling in SHR towards eccentric hypertrophy, which remained after detraining.…”

Section: Resultsmentioning

confidence: 99%

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[ARTIGO RETRATADO] Exercício e suas interações com vários aspectos da vida do homem e dos animais

Gomes¹,

Rocha-e-Silva²

2012

Acta ortop. bras.

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To review recently published papers in the Brazilian Scientific press on the general subject of physical exercise. All articles published in 2010/2011 found through the keyword exercise were collected from 11 Brazilian Journals. They were hand filtered to exclude all but original research papers. They were grouped according to subject categories and subcategories. A brief summary of all included articles was produced, comparing similar articles between them. The most commonly found interactions refer to exercise vs. the cardiovascular system, metabolism and the locomotor system, in this order. The volume of scientific research in the field is high and of sufficient quality to justify highlighting.

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Section: Resultscontrasting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

[ARTIGO RETRATADO] Exercício e suas interações com vários aspectos da vida do homem e dos animais

Gomes¹,

Rocha-e-Silva²

2012

Acta ortop. bras.

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“…The basic science themes of Pathology, Physiology and Molecular Biology are covered in 9 articles, 6 cardiac, 2 pulmonary, and one renal: Carneiro-Júnior et al [48] determined the effects of exercise training and detraining on the morphological and mechanical properties of left ventricular myocytes in 4-month-old spontaneously hypertensive rats (SHR) randomly divided into sedentary for 8 weeks, sedentary for 12 weeks, treadmill-running trained for 8 weeks (TRA, 16 m/min, 60 min/day, 5 days/ week), and treadmill-running trained for 8 weeks followed by 4 weeks of detraining. Cell length was greater in TRA than in SED-8 and remained larger after detraining.…”

Section: Kk and Rocha E Silva M -Cardiology In Brazilian Scientific Joumentioning

confidence: 99%

Cardiology in Brazilian scientific journals: an overview

Patel

Silva

2012

Rev Bras Cir Cardiovasc

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Cardiology has been and is a very significant fraction of the Brazilian contribution to science. In older days, the most significant part of this work was directed to foreign periodicals, but the quasi-simultaneous emergence of SciELO and PUBMED has ordained a redirection of much of this work to Brazilian periodicals. We here survey some of this more recent contribution for the benefit of readers of Revista Brasileira de Cirurgia Cardiovascular. This is offered as an update. Articles on the general themes of Cardiology and Pneumology published by four ISI Indexed Brazilian journals not specializing in cardiology are re-visited, after a search through 10 journals. ResumoA Cardiologia foi, e continua sendo, responsável por uma fracção muito significativa da contribuição brasileira para a ciência. No passado, os trabalhos mais importantes eram direcionados para periódicos estrangeiros, mas o surgimento quase simultâneo do SciELO e PUBMED facilitou um redirecionamento de grande parte desses trabalhos a periódicos brasileiros. Neste artigo, examinamos algumas das contribuições mais recentes em benefício aos leitores da Revista Brasileira de Cirurgia Cardiovascular. Esta discussão é oferecida como uma atualização. Artigos sobre os temas gerais da cardiologia e pneumologia publicados por quatro revistas brasileiras indexadas no ISI -não especializadas em cardiologia -são revistos.RBCCV

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“…A previous study showed that EET reduced the frequency and increased the amplitude of spontaneous Ca 2+ sparks in cardiomyocytes of diabetic rats, attenuating cardiac RyR2 dysregulation (10). Recently, our group showed that EET had beneficial effects on the molecular (11), mechanical (12), and electrical properties (13) of left ventricular myocytes of SHRs. However, whether the beneficial antihypertensive effects of EET can be extended to CRU components and Ca 2+ sparks needs to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Effect of exercise training on Ca2+ release units of left ventricular myocytes of spontaneously hypertensive rats

Carneiro‐Júnior

Quintão-Júnior

Drummond

et al. 2014

Braz J Med Biol Res

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In cardiomyocytes, calcium (Ca2+) release units comprise clusters of intracellular Ca2+ release channels located on the sarcoplasmic reticulum, and hypertension is well established as a cause of defects in calcium release unit function. Our objective was to determine whether endurance exercise training could attenuate the deleterious effects of hypertension on calcium release unit components and Ca2+ sparks in left ventricular myocytes of spontaneously hypertensive rats. Male Wistar and spontaneously hypertensive rats (4 months of age) were divided into 4 groups: normotensive (NC) and hypertensive control (HC), and normotensive (NT) and hypertensive trained (HT) animals (7 rats per group). NC and HC rats were submitted to a low-intensity treadmill running protocol (5 days/week, 1 h/day, 0% grade, and 50-60% of maximal running speed) for 8 weeks. Gene expression of the ryanodine receptor type 2 (RyR2) and FK506 binding protein (FKBP12.6) increased (270%) and decreased (88%), respectively, in HC compared to NC rats. Endurance exercise training reversed these changes by reducing RyR2 (230%) and normalizing FKBP12.6 gene expression (112%). Hypertension also increased the frequency of Ca2+ sparks (HC=7.61±0.26 vs NC=4.79±0.19 per 100 µm/s) and decreased its amplitude (HC=0.260±0.08 vs NC=0.324±0.10 ΔF/F0), full width at half-maximum amplitude (HC=1.05±0.08 vs NC=1.26±0.01 µm), total duration (HC=11.51±0.12 vs NC=14.97±0.24 ms), time to peak (HC=4.84±0.06 vs NC=6.31±0.14 ms), and time constant of decay (HC=8.68±0.12 vs NC=10.21±0.22 ms). These changes were partially reversed in HT rats (frequency of Ca2+ sparks=6.26±0.19 µm/s, amplitude=0.282±0.10 ΔF/F0, full width at half-maximum amplitude=1.14±0.01 µm, total duration=13.34±0.17 ms, time to peak=5.43±0.08 ms, and time constant of decay=9.43±0.15 ms). Endurance exercise training attenuated the deleterious effects of hypertension on calcium release units of left ventricular myocytes.

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Exercise training and detraining modify the morphological and mechanical properties of single cardiac myocytes obtained from spontaneously hypertensive rats

Cited by 18 publications

References 19 publications

[ARTIGO RETRATADO] Exercício e suas interações com vários aspectos da vida do homem e dos animais

[ARTIGO RETRATADO] Exercício e suas interações com vários aspectos da vida do homem e dos animais

Cardiology in Brazilian scientific journals: an overview

Effect of exercise training on Ca2+ release units of left ventricular myocytes of spontaneously hypertensive rats

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