Exercise Tolerance Measurements in Pulmonary Vascular Diseases and Chronic Heart Failure

Piepoli, Massimo F

doi:10.1159/000203697

Cited by 11 publications

(10 citation statements)

References 102 publications

(60 reference statements)

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“…Subnormal values have been associated with important residual hemodynamic defects after correction of the congenital heart lesion [11]. The lower values in our patient groups, might indicate an impaired oxygen flow to the peripheral exercising muscles, or alterations in the metabolism of the skeletal muscles [12]. These unknown peripheral factors may be the result of underlying congenital disturbances, or can be caused by low daily physical activity levels [6].…”

Section: Discussionmentioning

confidence: 64%

“…The adequacy of the oxygen transport was assessed by calculating the steepness of the slope of oxygen uptake versus exercise intensity during the graded exercise. To estimate the exercise intensity, we used the external work load [12]. Data from the entire exercise test were used in the regression analysis, except for the first minute.…”

Section: Measurementsmentioning

confidence: 99%

“…Furthermore, peak VO 2 measurement depends on a maximal effort on the exercise test, of which no certainty exists that this physiological maximum is or can always be reached by GUCH. To be independent from this end point, submaximal measures, such as ventilatory anaerobic threshold (VAT), Oxygen Uptake Efficiency Slope (OUES), oxygen uptake versus exercise intensity slope (VO 2 /WR slope) and the VE/VCO 2 slope, have been introduced [9,[11][12][13]. Most of these estimates of exercise tolerance have not been investigated in this population, or often only in small groups without a control group.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Measures of exercise capacity in adults with congenital heart disease

Buys

Cornelissen

Bruaene

et al. 2011

International Journal of Cardiology

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Section: Discussionmentioning

confidence: 64%

Section: Measurementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Measures of exercise capacity in adults with congenital heart disease

Buys

Cornelissen

Bruaene

et al. 2011

International Journal of Cardiology

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“…All patients learned not to overdo themselves and tolerated the training well without severe adverse events. The cardiopulmonary exercise test has become an important clinical tool in the management of patients with pulmonary disease [25,26,27] or chronic left heart failure (CHF) [28]. Thus, exercise capacity, 6MWT, QoL, WHO functional class, heart rate at rest and parameters of the cardiopulmonary exercise test were assessed and significantly improved after 15 weeks compared to baseline.…”

Section: Discussionmentioning

confidence: 99%

Effect of Exercise and Respiratory Training on Clinical Progression and Survival in Patients with Severe Chronic Pulmonary Hypertension

et al. 2011

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Background: Even though specific agents for the treatment of patients with pulmonary hypertension (PH) are available, in PH patients, physical capacity and quality of life (QoL) are often restricted and survival is reduced. Objectives: This study prospectively investigated the long-term effects of respiratory and exercise training in patients with severe chronic PH regarding safety, time to clinical worsening and survival. Methods: Fifty-eight consecutive patients with severe PH on stable disease-targeted medication received exercise and respiratory training in hospital for 3 weeks and continued at home. They were prospectively followed for 24 ± 12 months. Primary endpoints were time to clinical worsening and survival. Adverse events and changes in the 6-min walking test, QoL, WHO functional class and gas exchange were secondary endpoints and were evaluated at baseline and at weeks 3 and 15. Results: All patients tolerated the exercise training well without severe adverse events. In week 15, 6-min walking test results were significantly improved compared to baseline (by 84 ± 49 m, p < 0.001), as well as QoL scores, WHO functional class (from 2.9 ± 0.5 to 2.6 ± 0.6, p < 0.01), peak oxygen consumption (from 12.5 ± 3.0 to 14.6 ± 3.9 ml/min/kg, p < 0.001), heart rate at rest (from 75 ± 12 to 61 ± 18 beats/min, p < 0.001) and maximal workload (from 65 ± 21 to 80 ± 25 W, p < 0.001). Survival at 1 and 2 years was 100 and 95%, respectively. Fifteen events occurred during the follow-up. Conclusion: This study indicates that exercise and respiratory training as add-on to medical treatment may improve exercise capacity and QoL, and that they have a good long-term safety in the described setting.

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“…Hitherto, CPET is considered to be a better tool to assess overall health status (HS) than resting pulmonary function tests [1]. General theories define HS to include not merely physiological functioning, but also complaints, functional impairment and quality of life (QoL) as main domains [2,3].…”

Section: Introductionmentioning

confidence: 99%

Maximal Exercise Capacity in Chronic Obstructive Pulmonary Disease: A Limited Indicator of the Health Status

Verhage

Vercoulen²,

Helvoort³

et al. 2010

Respiration

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Background: Dyspnoea and diminished functional status are pivotal features of the health status (HS) in chronic obstructive pulmonary disease (COPD). However, it is still not fully understood how pulmonary function tests and cardiopulmonary exercise testing relate to these aspects. This may be due to incomplete assessment and/or deficient definitions of HS. Especially regarding peak oxygen consumption, inconsistent results have been reported. Objectives: To determine the value of maximal cycle ergometry in relation to a broad spectrum of HS aspects. Methods: 129 patients with COPD, stage II and III according to the GOLD classification, performed a cardiopulmonary exercise test. Sixteen independent sub-domains of HS were assessed according to the Nijmegen Integral Assessment Framework, covering physiological functioning, complaints, functional impairments and quality of life as main domains. v̇O₂_max and HS sub-domains were correlated by bivariate analysis. Results: Weak correlations of v̇O₂_max with most sub-domains were found, except for exercise capacity; the other 5 sub-domains of physiological functioning did not correlate. Between different types of exercise limitation (5 types were differentiated), no significant differences were noted in the scores of 13/16 HS sub-domains. Conclusions: v̇O₂_max is indeed correlated with most aspects of HS, except for physiological variables, but associations are weak. No single exercise limitation type is associated with specific HS problems. Thus separate assessment of all HS sub-domains is advocated to ensure adequate planning of therapeutic interventions.

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Exercise Tolerance Measurements in Pulmonary Vascular Diseases and Chronic Heart Failure

Cited by 11 publications

References 102 publications

Measures of exercise capacity in adults with congenital heart disease

Measures of exercise capacity in adults with congenital heart disease

Effect of Exercise and Respiratory Training on Clinical Progression and Survival in Patients with Severe Chronic Pulmonary Hypertension

Maximal Exercise Capacity in Chronic Obstructive Pulmonary Disease: A Limited Indicator of the Health Status

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