Measures of exercise capacity in adults with congenital heart disease

Buys, Roselien; Cornelissen, Véronique; Bruaene, Alexander Van De; Stevens, An; Coeckelberghs, Ellen; Onkelinx, Steven; Thomaes, Tom; Delecluse, Christophe; Budts, Werner; Vanhees, Luc

doi:10.1016/j.ijcard.2010.08.030

Cited by 80 publications

(69 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…during exercise, a further increase in heart rate enables a further increase in cardiac output. However, our results, in concordance with other studies, show that d-TGA patients present with chronotropic incompetence 2,3,5,8 .…”

Section: Study Limitationssupporting

confidence: 93%

“…In adults with atrial switch operation for transposition of the great arteries low physical activity relates to reduced exercise capacity and decreased perceived physical functioning which probably lowers faster with age compared to healthy controls 1,[3][4][5] . This reduced peak VO 2 has been related to impaired chronotropic response, impaired systemic ventricular function, impaired function of the intra-atrial conduit, the inability to increase stroke volume, impaired lung function and peripheral deconditioning 1,[4][5][6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In adults with atrial switch operation for transposition of the great arteries low physical activity relates to reduced exercise capacity and decreased perceived physical functioning

et al. 2012

Self Cite

View full text Add to dashboard Cite

Objective Patients with Mustard/Senning repair for transposition of the great arteries (d-TGA) have an impaired exercise capacity, but information about physical activity levels is scarce. The aim of the study was to come to a better understanding of the interrelationships between determinants of exercise capacity, physical activity and self-perceived health status. Methods and resultsWe studied 39 d-TGA patients who underwent echocardiography and exercise testing, and who completed questionnaires about physical activity and perceived health status. All results were compared with normal values. Stepwise multiple regression analysis was used to assess the determinants of peak VO 2 % and exercise duration. Peak VO 2 averaged 64 ± 14.1% of the predicted normal values, which is signifi cantly lower than expected (P < 0.0001). Physical activity measures as well as perceived general health were signifi cantly lower compared to a reference population (P < 0.05). Peak heart rate and peak oxygen pulse explained together 90% of the variability in exercise duration (model F = 162.72; P < 0.0001). Type of surgery, total energy expenditure and right ventricular contractility were independent predictors of peak VO 2 % explaining 43% of the variability (model F = 8.75; P = 0.0002).Conclusions Impaired peak exercise performance in d-TGA patients results mainly from the inability to increase stroke volume and heart rate at higher exercise intensities. Senning repair and a well-preserved right ventricular function are related to a better peak VO 2 %. Furthermore, an active lifestyle has a positive eff ect on exercise capacity and perceived physical functioning. Therefore it might be indicated to encourage d-TGA patients to adopt a more physically active lifestyle.

show abstract

Section: Study Limitationssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

In adults with atrial switch operation for transposition of the great arteries low physical activity relates to reduced exercise capacity and decreased perceived physical functioning

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

“…[16][17][18][19] In that patient population, the impact of surgical pulmonary valve replacement on exercise function has been small. 7,20,21 It is possible that these disappointing outcomes are due, in part, to the trauma and debilitation inevitably associated with major open heart surgery.…”

Section: Discussionmentioning

confidence: 99%

Cardiopulmonary exercise function among patients undergoing transcatheter pulmonary valve implantation in the US Melody valve investigational trial

Batra

McElhinney

Wang

et al. 2012

American Heart Journal

View full text Add to dashboard Cite

show abstract

“…[13][14][15] These factors include genetic disorders such as Down syndrome and cardiovascular diseases such as ischemic and hemorrhagic stroke, hypertension, heart failure, atrial fibrillation, and diabetes mellitus. [16][17][18][19][20][21][22] In addition, some adults with CHD have poor exercise tolerance, 23 which is a dementia risk factor. 24 In the absence of a disease-modifying treatment for most forms of dementia, the identification of factors with the potential to delay dementia onset is crucial.…”

mentioning

confidence: 99%

Risk of Dementia in Adults With Congenital Heart Disease

Bagge¹,

Henderson

Laursen³

et al. 2018

Circulation

View full text Add to dashboard Cite

Editorial, see p XXXBACKGROUND: More children with congenital heart disease (CHD) are surviving to adulthood, and CHD is associated with risk factors for dementia. We compared the risk of dementia in CHD adults to that of the general population. METHODS:In this cohort study, we used medical registries and a medical record review covering all Danish hospitals to identify adults with CHD diagnosed between 1963 and 2012. These individuals with CHD were followed from January 1, 1981, 30 years of age, or date of first CHD registration (index date for matched members of the general population cohort) until hospital diagnosis of dementia, death, emigration, or end of study (December 31, 2012). For each individual with CHD, we identified 10 members of the general population utilizing the Danish Civil Registration System matched on sex and birth year. We computed cumulative incidences and hazard ratios (HRs) of dementia, adjusting for sex and birth year. RESULTS:The cumulative incidence of dementia was 4% by 80 years of age in 10 632 adults with CHD (46% male). The overall HR comparing adults with CHD with the general population cohort was 1.6 (95% confidence interval [CI], 1.3−2.0). The HR among individuals with CHD without extracardiac defects was 1.4 (95% CI, 1.1−1.8). Adults with mild-to-moderate CHD had an HR of 1.5 (95% CI, 1.1−2.0), whereas the HR was 2.0 (95% CI, 1.2−3.3) for severe CHD, including univentricular hearts. The HR for early onset dementia (<65 years of age) was 2.6 (95% CI, 1.8−3.8), whereas the late-onset HR was 1.3 (95% CI, 1.0−1.8).CONCLUSIONS: CHD was associated with an increased risk of dementia compared with the general population, in particular for early onset dementia. Further understanding of dementia risk in the population with CHD is a potential target for future investigation.

show abstract

Measures of exercise capacity in adults with congenital heart disease

Cited by 80 publications

References 28 publications

In adults with atrial switch operation for transposition of the great arteries low physical activity relates to reduced exercise capacity and decreased perceived physical functioning

In adults with atrial switch operation for transposition of the great arteries low physical activity relates to reduced exercise capacity and decreased perceived physical functioning

Cardiopulmonary exercise function among patients undergoing transcatheter pulmonary valve implantation in the US Melody valve investigational trial

Risk of Dementia in Adults With Congenital Heart Disease

Contact Info

Product

Resources

About