Exercise Testing as a Long-Term Predictor of the Development of Microalbuminuria in Normoalbuminuric IDDM Patients

O’Brien, Sheila F; Watts, Gerald F.; Powrie, Jake; Shaw, Kenneth

doi:10.2337/diacare.18.12.1602

Cited by 16 publications

(11 citation statements)

References 11 publications

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“…O’Brien et al . [9] found microalbuminuria in 19% of their patients at 80% of exercise intensity, compared with eight of our 10 patients. However, only 73% of the patients in the study by O’Brien et al .…”

Section: Discussioncontrasting

confidence: 43%

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Effect of exercise intensity on albuminuria in adolescents with Type 1 diabetes mellitus

Kornhauser¹,

Malacara²,

Macías-Cervantes³

et al. 2011

Diabetic Medicine

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Section: Discussioncontrasting

confidence: 43%

“…The exercise test may be useful to detect patients prone to microalbuminuria [9]. According to Waden et al .…”

Section: Introductionmentioning

confidence: 99%

Effect of exercise intensity on albuminuria in adolescents with Type 1 diabetes mellitus

Kornhauser¹,

Malacara²,

Macías-Cervantes³

et al. 2011

Diabetic Medicine

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“…Considering the fact that albuminuria at rest is a marker of incipient diabetic nephropathy, this suggests that exercise induced albuminuria would be greater in case of pre-existing renal impairment[18]. This hypothesis is supported by physiology, since it is known that subclinical lesions can be unmasked even by moderate physical exercise[8]. The results obtained in this study shows a significant proportion of abnormal circadian BP profile in patients with T2D, considered normotensive on clinic-based measurements.…”

Section: Discussionmentioning

confidence: 99%

“…So, non-dipping nocturnal BP pattern defined as a less than 10% decrease in nocturnal BP, increase the risk of organ damage such as microalbuminuria[7]. In the other hand, exercise-induced albuminuria has been proposed as a long term predictive factor of overt diabetic nephropathy, but there is still a dearth of evidence on its usefulness in routine screening[8]. We sought to explore a possible relationship between resting and exercise-induced albuminuria, and circadian variations in BP levels on 24-h ambulatory blood pressure monitoring (ABPM).…”

Section: Introductionmentioning

confidence: 99%

Exercise-induced albuminuria and circadian blood pressure abnormalities in type 2 diabetes

Tankeu¹,

Kaze²,

Noubiap³

et al. 2017

WJN

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AIMTo investigate the relationship between circadian variations in blood pressure (BP) and albuminuria at rest, and during exercise in non-hypertensive type 2 diabetes (T2D) patients.METHODSWe conducted a cross-sectional study in well controlled T2D patients, non-hypertensive, without clinical proteinuria and normal creatinine clearance. In each participant, we recorded the BP using ambulatory blood pressure monitoring (ABPM) for 24-h, and albuminuria at rest and after a standardized treadmill exercise.RESULTSWe enrolled 27 type 2 patients with a median age of 52; and a mean duration of diabetes and HbA1c of 3.6 ± 0.8 years and 6.3% ± 0.5% respectively. Using a 24-h ABPM, we recorded a mean diurnal systolic blood pressure (SBP) of 128 ± 17 mmHg vs nocturnal of 123 ± 19 mmHg (P = 0.004), and mean diurnal diastolic blood pressure (DBP) of 83 ± 11 mmHg vs nocturnal 78 ± 14 mmHg (P = 0.002). There was a significant difference between albuminuria at rest [median = 23 mg, interquartile range (IQR) = 10-51] and after exercise (median = 35 mg, IQR = 23-80, P < 0.001). Patients with exercise induced albuminuria had an increase in nocturnal BP values on all three components (128 mmHg vs 110 mmHg, P = 0.03 for SBP; 83 mmHg vs 66 mmHg, P = 0.04; 106 vs 83, P = 0.02 for mean arterial pressure), as well as albuminuric patients at rest. Moreover, exercise induced albuminuria detect a less increase in nocturnal DBP (83 vs 86, P = 0.03) than resting albuminuria.CONCLUSIONExercise induced albuminuria is associated with an increase in nocturnal BP values in T2D patients.

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“…Stress tolerance test was given to adults and children with IDDM in order to predict the development of persistent microproteinuria and the risk of disease progression (19)(20)(21)(22)(23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Stress Tolerance Test and SDS-PAGE for the Analysis of Urinary Proteins in Children and Youths

Tasić

Korneti²,

Gucev³

et al. 2001

Clinical Chemistry and Laboratory Medicine

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Excretion of urinary proteins (UP) is an important marker for the evaluation of patients with progressive renal disease. In order to analyze quantitative and qualitative variability of UP in relation to physical activity, we used standardized stress tolerance test and SDS-PAGE. Five urine samples were obtained from each patient at rest, during ordinary daily activity and after physical stress. Determination of total proteins was performed using Meulman's classic method with sulfosalicylic acid. UP were separated by ultrathin horizontal gradient SDS-PAGE according to Görg. There were 142 patients; 40 with poststreptococcal glomerulonephritis (PSGN), 11 with diabetes mellitus, 16 with chronic pyelonephritis and 75 who attended for investigation of asymptomatic proteinuria. Functional proteinuria was established in 42 subjects, who displayed maximal UP excretion during stress and the presence of apolipoprotein AI on SDS-PAGE. Children with PSGN showed no significant increase of UP during stress. Some children with diabetes mellitus (27%) and chronic pyelonephritis (47%) displayed microproteinuria or overt proteinuria after stress. Quantitative and qualitative changes in total UP excretion can be detected by stress tolerance test and SDS-PAGE. It remains to be seen whether stress tolerance test can identify children and youths who are at higher risk for disease progression.

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Exercise Testing as a Long-Term Predictor of the Development of Microalbuminuria in Normoalbuminuric IDDM Patients

Abstract: Exercise testing may be useful for identifying normoalbuminuric IDDM patients who are susceptible to the later development of microalbuminuria.

Cited by 16 publications

References 11 publications

Effect of exercise intensity on albuminuria in adolescents with Type 1 diabetes mellitus

Effect of exercise intensity on albuminuria in adolescents with Type 1 diabetes mellitus

Exercise-induced albuminuria and circadian blood pressure abnormalities in type 2 diabetes

Stress Tolerance Test and SDS-PAGE for the Analysis of Urinary Proteins in Children and Youths

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