Exercise Modalities and Endothelial Function: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials

Ashor, Ammar W.; Lara, José; Siervo, Mario; Celis-Morales, Carlos; Oggioni, Clio; Jakovljevic, Djordje G.; Mathers, John C.

doi:10.1007/s40279-014-0272-9

Cited by 223 publications

(218 citation statements)

References 90 publications

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“…It is well known that regular aerobic exercise improves the quality of life of patients with CF through increasing expectoration of the sputum and ameliorating the decline in lung function (29,35). Exercise also enhances NO bioavailability (3,4,9). In the present study a positive correlation between the PORH-to-LTH ratio and exercise capacity suggests that a greater exercise capacity positively impacts microvascular function in CF.…”

Section: Microvascular Function and Disease Severity: Clinical Relevancesupporting

confidence: 59%

Evidence of microvascular dysfunction in patients with cystic fibrosis

Rodriguez‐Miguelez

Thomas

Seigler

et al. 2016

American Journal of Physiology-Heart and Circulatory Physiology

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Rodriguez-Miguelez P, Thomas J, Seigler N, Crandall R, McKie KT, Forseen C, Harris RA. Evidence of microvascular dysfunction in patients with cystic fibrosis. Am J Physiol Heart Circ Physiol 310: H1479 -H1485, 2016. First published April 15, 2016 doi:10.1152/ajpheart.00136.2016.-Cystic fibrosis (CF) is a genetic, multisystemic disorder with broad clinical manifestations apart from the well-characterized pulmonary dysfunction. Recent findings have described impairment in conduit vessel function in patients with CF; however, whether microvascular function is affected in this population has yet to be elucidated. Using laser-Doppler imaging, we evaluated microvascular function through postocclusive reactive hyperemia (PORH), local thermal hyperemia (LTH), and iontophoresis with acetylcholine (ACh). PORH [518 Ϯ 174% (CF) and 801 Ϯ 125% (control), P ϭ 0.039], LTH [1,338 Ϯ 436% (CF) and 1,574 Ϯ 620% (control), P ϭ 0.045], and iontophoresis with ACh [416 Ϯ 140% (CF) and 617 Ϯ 143% (control), P ϭ 0.032] were significantly lower in patients with CF than control subjects. In addition, the ratio of PORH to LTH was significantly (P ϭ 0.043) lower in patients with CF (55.3 Ϯ 5.1%) than control subjects (68.8 Ϯ 3.1%). Significant positive correlations between LTH and forced expiratory volume in 1 s (%predicted) (r ϭ 0.441, P ϭ 0.013) and between the PORH-to-LTH ratio and exercise capacity (r ϭ 0.350, P ϭ 0.049) were observed. These data provide evidence of microvascular dysfunction in patients with CF compared with control subjects. In addition, our data demonstrate a complex relationship between microvascular function and classical markers of disease severity (i.e., pulmonary function and exercise capacity) in CF. CYSTIC FIBROSIS (CF) is an inherited disorder that is predominantly characterized by pulmonary dysfunction; however, broader clinical manifestations, such as gastrointestinal, immune, endocrine, and musculoskeletal dysfunctions, are also present (36). Recently, our group reported conduit vascular endothelial dysfunction in young patients with CF (39). Importantly, this vascular impairment was observed in a population that exhibited preserved spirometric function and exercise capacity, which suggests a systemic consequence prior to the decrease in pulmonary function. Despite these recent observations, there appears to be a lack of understanding of the general functionality of the endothelium in CF.Impairments in endothelial function are highly related to a reduction in the bioavailability of nitric oxide (NO), a key vasodilator involved in the regulation of vessel tone and endothelium integrity (24). Decreases in NO balance have also been shown to contribute to impaired endothelial microvascular vasodilation (44). With use of laser-Doppler imaging technology, cutaneous blood flux can be quantified (45) to represent an accessible model of microvascular function (17). Postocclusive reactive hyperemia (PORH), local thermal hyperemia (LTH), and iontophoresis with acetylcholine (ACh), in combination with laser technology...

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Section: Microvascular Function and Disease Severity: Clinical Relevancesupporting

confidence: 59%

Evidence of microvascular dysfunction in patients with cystic fibrosis

Rodriguez‐Miguelez

Thomas

Seigler

et al. 2016

American Journal of Physiology-Heart and Circulatory Physiology

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“…Una reciente revisión concluyó que tanto el ejercicio aeróbico como de fuerza mejoran la función endotelial 32 . Se han descrito como mecanismos responsables del efecto hipotensor, la reducción de la resistencia vascular periférica 33 , la angiogénesis 34 , el estrés por roce, y la producción de óxido nítrico 11 .…”

Section: Discussionunclassified

Interacción entre farmacoterapia hipotensiva y terapia con ejercicio físico requiere regulación farmacológica en pacientes hipertensos

et al. 2016

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“…Indeed, plasma concentrations of soluble LOX-1 were correlated with arterial stiffness 30) . However, aerobic training improves endothelial function 34,35) and increases functional sympatholysis 17) . In addition, Mortensen et al reported that functional sympatholysis is preserved in physically active older individuals 36) .…”

Section: Aerobic Exercise Sbpmentioning

confidence: 99%

Effects of habitual exercise on blood pressure during aerobic and resistance exercise in older individuals

Otsuki

2017

JPFSM

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Blood pressure increases transiently during exercise in proportion to exercise intensity as a response to the increased demand for blood flow to the muscles. However, in addition to exercise intensity, many factors, including age and arterial stiffness, affect blood pressure during exercise. Aerobic exercises such as walking and cycling and resistance exercises such as lifting objects and climbing stairs are part of daily life activities. Therefore, exaggerated blood pressure responses to exercise increase the risk of cardiovascular disease. In this paper, the effects of habitual exercise on blood pressure during aerobic and resistance exercise are reviewed. Keywords : exercise blood pressure, exercise training, resistance exercise, aerobic exercise Exaggerated blood pressure response to exerciseBlood pressure transiently increases during aerobic 1-3) and resistance 4,5) exercise in proportion to exercise intensity as a response to the increased demand for blood flow to the muscles. However, many other factors besides exercise intensity affect blood pressure during exercise. We previously explored factors affecting blood pressure during self-paced outdoor walking using a wrist-type blood pressure monitor 6) . Systolic blood pressure (SBP) was higher during walking compared to the resting state, but the increase in SBP was greater at the 1 km mark than at the 2 and 3 km marks. In stepwise regression analysis, air temperature and body mass index (BMI), as well as resting SBP and walking pace, were identified as independent predictors of SBP during walking. In laboratory tests during which exercise intensity was strictly controlled according to the testing protocol, age was an important factor affecting SBP during exercise; subjects older than 70 years had higher SBP during cycling than subjects in their 60s 3) . With regard to resistance exercise, age, sex, arterial stiffness, BMI, and use of antihypertensive medication, as well as resting SBP, were identified as independent predictors of SBP during exercise 5)

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Exercise Modalities and Endothelial Function: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials

Abstract: All exercise modalities improve EF significantly and there was a significant, positive relationship between aerobic exercise intensity and EF. Greater frequency, rather than intensity, of resistance exercise training enhanced EF.

Cited by 223 publications

References 90 publications

Evidence of microvascular dysfunction in patients with cystic fibrosis

Evidence of microvascular dysfunction in patients with cystic fibrosis

Interacción entre farmacoterapia hipotensiva y terapia con ejercicio físico requiere regulación farmacológica en pacientes hipertensos

Effects of habitual exercise on blood pressure during aerobic and resistance exercise in older individuals

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