Exercise mitigates age-related metabolic diseases by improving mitochondrial dysfunction

Jia, Dandan; Tian, Zhenjun; Wang, Ru

doi:10.1016/j.arr.2023.102087

Cited by 4 publications

(1 citation statement)

References 237 publications

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“…Furthermore, mitochondrial dysfunction can lead to alterations in ion gradients near synapses, elevated intracellular ion concentrations, activation of proapoptotic factors, and subsequent occurrence of LTD, affecting synaptic connectivity, information transfer efficiency, and synaptic plasticity among neurons (Collier et al, 2023;Jia et al, 2023).…”

Section: Mitophagy Affects Synaptic Plasticity and Learning By Alteri...mentioning

confidence: 99%

Advancements in the study of synaptic plasticity and mitochondrial autophagy relationship

Zhu,

Hui,

Zhang

et al. 2024

J of Neuroscience Research

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Synapses serve as the points of communication between neurons, consisting primarily of three components: the presynaptic membrane, synaptic cleft, and postsynaptic membrane. They transmit signals through the release and reception of neurotransmitters. Synaptic plasticity, the ability of synapses to undergo structural and functional changes, is influenced by proteins such as growth‐associated proteins, synaptic vesicle proteins, postsynaptic density proteins, and neurotrophic growth factors. Furthermore, maintaining synaptic plasticity consumes more than half of the brain's energy, with a significant portion of this energy originating from ATP generated through mitochondrial energy metabolism. Consequently, the quantity, distribution, transport, and function of mitochondria impact the stability of brain energy metabolism, thereby participating in the regulation of fundamental processes in synaptic plasticity, including neuronal differentiation, neurite outgrowth, synapse formation, and neurotransmitter release. This article provides a comprehensive overview of the proteins associated with presynaptic plasticity, postsynaptic plasticity, and common factors between the two, as well as the relationship between mitochondrial energy metabolism and synaptic plasticity.

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Section: Mitophagy Affects Synaptic Plasticity and Learning By Alteri...mentioning

confidence: 99%

Advancements in the study of synaptic plasticity and mitochondrial autophagy relationship

Zhu,

Hui,

Zhang

et al. 2024

J of Neuroscience Research

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Exercise and nutrition benefit skeletal muscle: From influence factor and intervention strategy to molecular mechanism

Feng,

Li,

Yong

et al. 2024

Sports Medicine and Health Science

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FGF21 improves ventricular remodeling in TAC induced heart failure rats

Fan,

Yan,

et al. 2024

Preprint

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Background: Studies have found that elevated serum fibroblast growth factor 21 (FGF21) levels in patients with heart failure (HF) predicted poor prognosis. While preclinical studies have found that FGF21 plays a favorable role in the pathophysiological process of heart failure. Clinically, this increase in serum FGF21 seems to contradict the results of preclinical studies, therefore, the purpose of this study was to analyze whether FGF21 can improve ventricular remodeling in the HF rats, thereby improving cardiac function. Methods: The HF model of transverse aortic coarctation (TAC) was conducted and divided into 4 groups: sham group (Sham), TAC model group (TAC), TAC+FGF21 neutralizing antibody (FGF21nAb) group (TAC+FGF21nAb), and TAC+FGF21nAb+recombinant mouse FGF21 (rmFGF21) group (TAC+FGF21nAb+rmFGF21). Echocardiography, hematoxylin-eosin staining (HE), Masson staining, enzyme linked immunosorbent assay (ELISA) and western blot (WB) were used to evaluate the changes of cardiac structure and function in each group. The adenosine triphosphate (ATP) in myocardial tissue was determined by colorimetry. The level of reactive oxygen species (ROS) in myocardial tissue was determined by chemiluminescence method. Results: Serum FGF21 level in the TAC+FGF21nAb group was significantly lower than that in the TAC group (29.42±8.54pg/ml vs1886.65±169.51 pg/ml, P<0.001). Compared with the Sham group, left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS)were significantly decreased (P<0.001), with a significant increase in serum B-type natriuretic peptide (BNP) levels (P<0.05) in the TAC group and TAC+FGF21nAb group. However, after 3 weeks of rmFGF21 treatment, LVEF and LVFS were significantly increased (P<0.001), and serum BNP was significantly decreased (P<0.001). Compared to the Sham group, the heart mass significantly increased (P<0.01), myocardial cell hypertrophy, inflammatory cell infiltration，a large amount of fiber deposits in myocardium and around blood vessels, ROS level significantly increased (P<0.001), and the ATP content was significantly decreased (P<0.001) were observed in the TAC group and TAC+FGF21nAb group. While rmFGF21 could improve the above phenomenon. Conclusion: FGF21 can improve ventricular remodeling and cardiac function in HF rats by anti-inflammation, anti-fibrosis, reducing oxidative stress and regulating energy metabolism.

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Exercise mitigates age-related metabolic diseases by improving mitochondrial dysfunction

Cited by 4 publications

References 237 publications

Advancements in the study of synaptic plasticity and mitochondrial autophagy relationship

Advancements in the study of synaptic plasticity and mitochondrial autophagy relationship

Exercise and nutrition benefit skeletal muscle: From influence factor and intervention strategy to molecular mechanism

FGF21 improves ventricular remodeling in TAC induced heart failure rats

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