Exercise Metabolism in Nonobese Patients with Type 2 Diabetes Following the Acute Restoration of Normoglycaemia

Abstract

This study investigated how acute restoration of normoglycaemia affected energy metabolism during exercise in nonobese patients with type 2 diabetes. Six subjects (mean ± SEM) aged 56.2 ± 2.7 years, with a BMI of 24.5 ± 1.5 kg/m2 and a VO2 peak of 28.7 ml/kg/min, attended the lab on two randomised occasions for a four-hour resting infusion of insulin or saline, followed by 30 minutes cycling at 50% VO2 peak. During the 4 h resting infusion, there was a greater (P < 0.0001) reduction in blood glucose in insulin treatment (INS) (from 11.2 ± 0.6 to 5.6 ± 0.1 mmol/l) than in saline treatment/control (CON) (from 11.5 ± 0.7 to 8.5 ± 0.6 mmol/l). This was associated with a lower (P < 0.05) resting metabolic rate in INS (3.87 ± 0.17) than in CON (4.39 ± 0.30 kJ/min). During subsequent exercise, blood glucose increased significantly in INS from 5.6 ± 0.1 at 0 min to 6.3 ± 0.3 mmol/l at 30 min (P < 0.01), which was accompanied by a lower blood lactate response (P < 0.05). Oxygen uptake, rates of substrate utilization, heart rate, and ratings of perceived exertion were not different between trials. Insulin-induced normoglycaemia increased blood glucose during subsequent exercise without altering overall substrate utilization.

Peran Aktivitas Fisik terhadap Massa Otot Pasien Diabetes Melitus Tipe 2: Systematic Literatur Riview

“…Seiring dengan hal tersebut, penurunan massa otot pun dapat dihambat dengan meningkatkan sintesis protein di otot melalui efek aktivitas fisik (Colberg et al, 2016). Selain itu, aktivitas fisik pada pasien DM tipe 2 dapat memperbaiki IMT, memperbaiki sensitivitas insulin, dan mencegah komplikasi (Gaffney, Mansell, Stephens, Macdonald, and Tsintzas, 2017;Gray, Picone, Sloan, and Yashkin, 2016;Sudarsono, 2015). Berlawanan dengan hal tersebut, tren aktivitas fisik saat ini menunjukkan pergeseran ke arah negatif akibat kemajuan teknologi di zaman modern (WHO, 2011).…”

Maintenance of plasma glucose variability after an acute session of aerobic exercise despite changes in insulin and glucagon-like peptide-1 levels in type 2 diabetes

“…The hormonal response to exercise could be affected in diabetes: postprandial suppression of glucagon, increase of GLP-1, and no change in insulin levels was observed in diabetes patients one day after performing two long bouts of exercise (13). Although other studies have shown no change in insulin levels after acute sessions of aerobic exercise (14,15), other authors reported a reduction in these levels (16), while glucagon levels were found to have increased after aerobic exercise (17), and GLP-1 levels decreased during post-dinner resistance exercise (18). Thus, the present study aimed to evaluate glucose variability and hormonal responses during and after an aerobic exercise session performed after breakfast in type 2 diabetes subjects, treated with metformin.…”