Exercise-Mediated Browning of White Adipose Tissue: Its Significance, Mechanism and Effectiveness

Mu, Wang-Jing; Zhu, Jieying; Chen, Min; Guo, Liang

doi:10.3390/ijms222111512

Cited by 44 publications

(23 citation statements)

References 67 publications

(84 reference statements)

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“…In addition, a strong body of evidence suggests that mechanical stress stimulation directly induced by exercise can affect the osteogenic and lipogenic differentiation processes of bone mesenchymal stem cells (BMSCs) ( 34 ). Mechanical loading has a positive effect on osteogenic differentiation of BMSCs, mainly by promoting osteogenic differentiation and inhibiting lipogenic differentiation, which may also be one of the main reasons for the prevention of OP by BDJ exercise.…”

Section: The Possible Mechanism Of Baduanjin Exercisementioning

confidence: 99%

“…BDJ exercise is a full-body exercise, and all forms of BDJ exercise combine rhythmic movements or fixed body postures with deep breathing techniques to reduce the appearance of pain, which may be closely related to the matching of breathing rate. Some studies have pointed out that during the exercise, the spine, especially the neck, can perform movements such as twisting, extension and forward flexion, which can fully relax the muscles of the neck and lower limbs, reduce pain-causing stimulation, and improve pain behavior and physical activity tolerance ( 34 ).…”

Section: The Possible Mechanism Of Baduanjin Exercisementioning

confidence: 99%

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Baduanjin exercise: A potential promising therapy toward osteoporosis

Sun

Huang

et al. 2022

Front. Med.

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PurposeBaduanjin (BDJ) exercise is a traditional exercise that combines breathing, body movement, meditation and awareness to help delay the onset and progression of senile degenerative musculoskeletal diseases, such as osteoporosis (OP). The aim of this meta-analysis is to evaluate the efficacy of BDJ exercise, and preliminarily infer its effective mechanism in the treatment of OP.MethodsWe identified relevant randomized controlled trials (RCTs) through eight databases, and compared BDJ exercise with the control groups (including blank control and conventional treatment intervention). The main outcome measure was bone mineral density (BMD), the additional outcome measures were visual analogue scale (VAS), Berg balance scale (BBS), serum Calcium (Ca), serum Phosphorus (P), serum Alkaline phosphatase (ALP), and serum bone gla protein (BGP). Meta-analysis and trial sequence analysis (TSA) were performed using RevMan 5.4, Stata 16.0, and TSA 0.9.ResultsIn total, 13 RCTs involving 919 patients were included in the analysis. For postmenopausal osteoporosis, BDJ exercise alone and BDJ exercise combined with conventional treatment can improve the BMD of lumbar spine. BDJ exercise alone can influence serum Ca and ALP. BDJ exercise combined with conventional treatment can improve balance (BBS) and influence serum BGP. For senile osteoporosis, BDJ exercise alone and BDJ exercise combined with conventional treatment can improve balance (BBS). BDJ exercise combined with conventional treatment can improve the BMD of hip and pain relieve (VAS). For primary osteoporosis, BDJ exercise combined with conventional treatment can improve the BMD of lumbar spine and femoral neck.ConclusionBaduanjin exercise may be beneficial to improve BMD, relieve pain, improve balance ability, influence serum BGP and serum ALP in patients with OP, but differences occur due to various types of OP. Due to the low quality of research on the efficacy and mechanism of BDJ exercise in the treatment of OP, high-quality evidence-based research is still needed to provide reliable supporting evidence.Systematic Review Registration[http://www.crd.york.ac.uk/PROSPERO], identifier [CRD42022329022].

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Section: The Possible Mechanism Of Baduanjin Exercisementioning

confidence: 99%

Section: The Possible Mechanism Of Baduanjin Exercisementioning

confidence: 99%

Baduanjin exercise: A potential promising therapy toward osteoporosis

Sun

Huang

et al. 2022

Front. Med.

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“…In obesity, regular physical activity reduces adipose tissue and weight and improves fat browning by increasing UCP1 ( Reisi et al, 2016 ; Mu et al, 2021 ). During exercise, triacylglycerols, an adipose tissue energy metabolite, are hydrolyzed into free fatty acids (FA), which are then released into the circulation to empower the muscle to function ( Mika et al, 2019 ).…”

Section: Asprosin In Exercise-regulating Metabolic Diseasesmentioning

confidence: 99%

The Effects of Asprosin on Exercise-Intervention in Metabolic Diseases

et al. 2022

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Fibrillin is the major constituent of extracellular microfibrils, which are distributed throughout connective tissues. Asprosin is derived from the C-terminal region of the FBN1 gene, which encodes profibrillin that undergoes cleavage by furin protein. In response to fasting with low dietary glucose, asprosin is released as a secreted factor from white adipose tissue, and is transported to the liver for the mediation of glucose release into the blood circulation. Through binding to OLFR734, an olfactory G-protein-coupled receptor in liver cells, asprosin induces a glucogenic effect to regulate glucose homeostasis. Bioinformatics analyses revealed that the FBN1 gene is abundantly expressed in human skeletal muscle-derived mesoangioblasts, osteoblast-like cells, and mesenchymal stem cells, indicating that the musculoskeletal system might play a role in the regulation of asprosin expression. Interestingly, recent studies suggest that asprosin is regulated by exercise. This timely review discusses the role of asprosin in metabolism, its receptor signalling, as well as the exercise regulation of asprosin. Collectively, asprosin may have a vital regulatory effect on the improvement of metabolic disorders such as diabetes mellitus and obesity via exercise.

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“…It is characterized by the existence of steatosis in over 5 % of hepatocytes and results in a wide range of metabolic alterations from hepatic lipotoxicity and inflammation to more severe nonalcoholic steatohepatitis (NASH) with striking fibrosis in liver [5][6][7][8]. Exercise is a currently effective strategy to treat NAFLD [6,[9][10][11][12][13]. However, the underlying mechanisms of the positive effects of exercise on the alleviation of NAFLD are still incompletely understood.…”

Section: Introductionmentioning

confidence: 99%