Exercise-Induced Circulating Hematopoietic Stem and Progenitor Cells in Well-Trained Subjects

Kröpfl, Julia M.; Beltrami, Fernando G.; Gruber, Hans-Jürgen; Stelzer, Ingeborg; Spengler, Christina M.

doi:10.3389/fphys.2020.00308

Cited by 11 publications

(15 citation statements)

References 35 publications

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Section: Discussionsupporting

confidence: 89%

“…It is known that high-intensity interval exercise-induced oxidative stress is similar between runners and cyclists 17,22 , which could be confirmed in the present study. In the same study 17 , TAC values after exercise cessation were also not modality-dependent. Furthermore, we could show that traditional highintensity interval exercise did not perturbate the anti-oxidative side of the redox system enough to evoke significant TAC changes, while TOC decreased post-exercise.…”

Section: Discussionsupporting

confidence: 89%

“…This study was part of a larger project 16 . However, the primary aims addressed in the current paper are novel and are exclusively dealt within this study alone with no overlap between this investigation and others 16,17 .…”

Section: Methodsmentioning

confidence: 99%

“…A single high-intensity interval training session was used, which is known to pertubate the redox system post-exercise 18,19 . Unlike in our previous work 17 , an interval exercise protocol with decremental workloads (DEC) during the intense bouts of exercise was applied, please see Fig. 1 for details.…”

Section: Methodsmentioning

confidence: 99%

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Acute exercise-induced glycocalyx shedding does not differ between exercise modalities, but is associated with total antioxidative capacity

Kröpfl

Beltrami

Rehm

et al. 2021

Journal of Science and Medicine in Sport

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Acute exercise-induced glycocalyx shedding does not differ between exercise modalities, but is associated with total antioxidative capacity

Kröpfl

Beltrami

Rehm

et al. 2021

Journal of Science and Medicine in Sport

Self Cite

View full text Add to dashboard Cite

show abstract

“…Sympathetic activity to the bone marrow, elicited by physical exercise, is an additional possibility by which exercise may change the mobilization of hematopoietic stem and progenitors cells (HSPC) into peripheral circulation and subsequently change the number and function of leukocytes. However, these effects are highly dependent on the intensity of the exercise and may be transient (Emmons et al, 2016;Kröpfl et al, 2020). Finally, exercise FIGURE 6 | Bone marrow from exercised donor mice reduces atherosclerosis in recipient sedentary mice.…”

Section: Discussionmentioning

confidence: 99%

The Anti-atherogenic Role of Exercise Is Associated With the Attenuation of Bone Marrow-Derived Macrophage Activation and Migration in Hypercholesterolemic Mice

et al. 2020

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An early event in atherogenesis is the recruitment and infiltration of circulating monocytes and macrophage activation in the subendothelial space. Atherosclerosis subsequently progresses as a unresolved inflammatory disease, particularly in hypercholesterolemic conditions. Although physical exercise training has been a widely accepted strategy to inhibit atherosclerosis, its impact on arterial wall inflammation and macrophage phenotype and function has not yet been directly evaluated. Thus, the aim of this study was to investigate the effects of aerobic exercise training on the inflammatory state of atherosclerotic lesions with a focus on macrophages. Hypercholesterolemic LDL-receptor-deficient male mice were subjected to treadmill training for 8 weeks and fed a high-fat diet. Analyses included plasma lipoprotein and cytokine levels; aortic root staining for lipids (oil red O); macrophages (CD68, MCP1 and IL1β); oxidative (nitrotyrosine and, DHE) and endoplasmic reticulum (GADD) stress markers. Primary bone marrow-derived macrophages (BMDM) were assayed for migration activity, motility phenotype (Rac1 and F-actin) and inflammation-related gene expression. Plasma levels of HDL cholesterol were increased, while levels of proinflammatory cytokines (TNFa, IL1b, and IL6) were markedly reduced in the exercised mice. The exercised mice developed lower levels of lipid content and inflammation in atherosclerotic plaques. Additionally, lesions in the exercised mice had lower levels of oxidative and ER stress markers. BMDM isolated from the exercised mice showed a marked reduction in proinflammatory cytokine gene expression and migratory activity and a disrupted motility phenotype. More importantly, bone marrow from exercised mice transplanted into sedentary mice led to reduced atherosclerosis in the recipient sedentary mice, thus suggesting that epigenetic mechanisms are associated with exercise. Collectively, the presented data indicate that exercise training prevents atherosclerosis by inhibiting bone marrow-derived macrophage recruitment and activation.

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Pax7+ Satellite Cells in Human Skeletal Muscle After Exercise: A Systematic Review and Meta-analysis

et al. 2022

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Exercise-Induced Circulating Hematopoietic Stem and Progenitor Cells in Well-Trained Subjects

Cited by 11 publications

References 35 publications

Acute exercise-induced glycocalyx shedding does not differ between exercise modalities, but is associated with total antioxidative capacity

Acute exercise-induced glycocalyx shedding does not differ between exercise modalities, but is associated with total antioxidative capacity

The Anti-atherogenic Role of Exercise Is Associated With the Attenuation of Bone Marrow-Derived Macrophage Activation and Migration in Hypercholesterolemic Mice

Pax7+ Satellite Cells in Human Skeletal Muscle After Exercise: A Systematic Review and Meta-analysis

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