Exercise-induced changes of gene expression in the cerebellum of aged mice

Lee, Min Chul; Cho, Hae-Sung; Yoon, Kyeong Jin; Lee, WonSang; Moon, Hyo Youl

doi:10.1016/j.bbrc.2019.11.024

Cited by 6 publications

(8 citation statements)

References 28 publications

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“…Polymorphisms in the human CerS1 gene that resulted in enhanced CerS1 activity were associated with higher longevity, 36 while CerS1 activity reducing mutations were linked to epilepsy and dementia 37 . CerS1 expression was upregulated in aged mice 38 . A specific reduction of CerS1 expression was found in the striatum and cortex of mice expressing Huntington's disease symptoms 39 …”

Section: Discussionmentioning

confidence: 98%

Cocaine attenuates acid sphingomyelinase activity during establishment of addiction‐related behavior—A translational study in rats and monkeys

et al. 2020

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Cocaine addiction is a severe psychiatric condition for which currently no effective pharmacotherapy is available. Brain mechanisms for the establishment of addiction‐related behaviors are still not fully understood, and specific biomarkers for cocaine use are not available. Sphingolipids are major membrane lipids, which shape neuronal membrane composition and dynamics in the brain. Here, we investigated how chronic cocaine exposure during establishment of addiction‐related behaviors affects the activity of the sphingolipid rheostat controlling enzymes in the brain of rats. As we detected specific effects on several enzymes in the brain, we tested whether the activity of selected enzymes in the blood may serve as potential biomarker for cocaine exposure in non‐human primates (Callithrix penicillata). We found that intravenous cocaine self‐administration led to a reduced mRNA expression of Cers1, Degs1 and Degs2, and Smpd1 in the prefrontal cortex of rats, as well as a reduction of Cers4 expression in the striatum. These effects reversed after 10 days of abstinence. Monkeys showed a robust cocaine‐induced place preference (CPP). This coincided with a reduction in blood acid sphingomyelinase (ASM) activity after CPP establishment. This effect normalized after 15 days of abstinence. Altogether, these findings suggest that the establishment of cocaine addiction‐related behaviors coincides with changes in the activity of sphingolipid controlling enzymes. In particular, blood ASM levels may serve as a translational biomarker for recent cocaine exposure.

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Section: Discussionmentioning

confidence: 98%

Cocaine attenuates acid sphingomyelinase activity during establishment of addiction‐related behavior—A translational study in rats and monkeys

et al. 2020

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“…All procedures were based on previously published data [ 63 ]. Briefly, the 9-week-old C57BL/6 young male mice and 84-week-old mice were purchased from Central Lab.…”

Section: Methodsmentioning

confidence: 99%

“…Each group comprised three mice and all mice were subjected to RNA sequencing analysis. Details on animal care were provided in a previous study [ 63 ].…”

Section: Methodsmentioning

confidence: 99%

“…All procedures were based on a previous study [ 63 ]. Briefly, total RNA was extracted from SOL and GAS of mice using a total RNA extraction kit (Ribozol, Amresco) following the manufacturer’s protocol.…”

Section: Methodsmentioning

confidence: 99%

“…Briefly, total RNA was extracted from SOL and GAS of mice using a total RNA extraction kit (Ribozol, Amresco) following the manufacturer’s protocol. The remaining processes, including cDNA synthesis, check for purity and integrity were presented in previously published data [ 63 ].…”

Section: Methodsmentioning

confidence: 99%

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Muscle fiber type-dependence effect of exercise on genomic networks in aged mice models

Lee

Bae

et al. 2022

Aging

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Skeletal muscles are made up of various muscle fiber type including slow and fast-twitch fibers. Because each muscle fiber has its own physiological characteristics, the effects of aging and exercise vary depending on the type of muscle fiber. We used bioinformatics screening techniques such as differentially expressed gene analysis, gene ontology analysis and gene set enrichment analysis, to try to understand the genetic differences between muscle fiber types. The experiment and gene expression profiling in this study used the soleus (SOL, slow-twitch muscle) and gastrocnemius (GAS, fast-twitch muscle). According to our findings, fatty acid metabolism is significantly up-regulated in SOL compared to GAS, whereas the glucose metabolism pathway is significantly down-regulated in SOL compared to GAS. Furthermore, apoptosis and myogenesis patterns differ between SOL and GAS. SOL did not show differences in apoptosis due to the aging effect, but apoptosis in GAS was significantly up-regulated with age. Apoptosis in GAS of old groups is significantly reduced after 4 weeks of aerobic exercise, but no such finding was found in SOL. In terms of myogenesis, exercise intervention up-regulated this process in GAS of old groups but not in SOL. Taken together, muscle fiber type significantly interacts with aging and exercise. Despite the importance of the interaction between these factors, large-scale gene expression data has rarely been studied. We hope to contribute to a better understanding of the relationship between muscle fiber type, aging and exercise at the molecular level.

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Caspase-12 is Expressed in Purkinje Neurons and Prevents Psychiatric-Like Behavior in Mice

Huang,

Liu,

Chen

et al. 2024

Mol Neurobiol

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Exercise-induced changes of gene expression in the cerebellum of aged mice

Cited by 6 publications

References 28 publications

Cocaine attenuates acid sphingomyelinase activity during establishment of addiction‐related behavior—A translational study in rats and monkeys

Cocaine attenuates acid sphingomyelinase activity during establishment of addiction‐related behavior—A translational study in rats and monkeys

Muscle fiber type-dependence effect of exercise on genomic networks in aged mice models

Caspase-12 is Expressed in Purkinje Neurons and Prevents Psychiatric-Like Behavior in Mice

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