Exercise-induced AMPK activation and IL-6 muscle production are disturbed in adiponectin knockout mice

AMP‐activated protein kinase activation in skeletal muscle modulates exercise‐induced uncoupled protein 1 expression in brown adipocyte in mouse model

“…Incidentally, the AICAR-treated C2C12 myotubes released a significantly high amount of IL-6 and a significantly low amount of MCP-1. These results are consistent with those of previous studies, which report an increase in IL-6 and a decrease in MCP-1 during exercise (Diniz et al, 2019;Troseid et al, 2004). Moreover, previous studies have also reported that an increase in IL-6 promotes UCP1 expression, and a decrease in MCP-1 promotes browning of adipocytes (Laurens et al, 2020;Rajasekaran et al, 2019;Severinsen & Pedersen, 2020).…”

Exercise Training Improves Memory Performance in Older Adults: A Narrative Review of Evidence and Possible Mechanisms

“…Adiponectin receptor-1 knockdown mice exhibited spatial learning and memory impairment , however exercise training exerts anti-inflammatory and insulin-sensitizing effects via elevating adiponectin and inhibiting TNFα and IL-6 (Tore et al, 2007;Rizzo et al, 2020). Administration of exogen adiponectin improves learning and memory (Tore et al, 2007), similar to the exercise-induced elevated adiponectin level (Martinez-Huenchullan et al, 2018;Pousti et al, 2018;Diniz et al, 2019;Parastesh et al, 2019) in animal studies.…”

The antitumor mechanisms of aerobic exercise: A review of recent preclinical studies

“…Exercise is one of the factors that activate AMPK, and low to moderate intensity aerobic exercise can significantly enhance the activity of AMPK 62 . Liver kinase B1 (LKB1) inhibits mTOR by activating AMPK under low ATP conditions, and the depletion of large amounts of ATP during exercise elevates the AMP/ATP ratio and activates AMPK mediated by LKB1 63,64 .…”

“…61 Exercise is one of the factors that activate AMPK, and low to moderate intensity aerobic exercise can significantly enhance the activity of AMPK. 62 Liver kinase B1 (LKB1) inhibits mTOR by activating AMPK under low ATP conditions, and the depletion of large amounts of ATP during exercise elevates the AMP/ATP ratio and activates AMPK mediated by LKB1. 63,64 VEGF is able to promote angiogenesis by modulating cellular metabolism through the activation of the AMPK signaling pathway under conditions of Ca 2+ /calmodulindependent protein kinase kinase (CaMKK-β) phosphorylation in normal conditions.…”