Exercise Increases Adiponectin Levels and Insulin Sensitivity in Humans

Kriketos, Adamandia D.; Gan, Seng Khee; Poynten, Ann M.; Furler, Stuart M.; Chisholm, Donald J.; Campbell, Lesley V.

doi:10.2337/diacare.27.2.629

Cited by 192 publications

(160 citation statements)

References 8 publications

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“…Kriketos et al (2004) reported a significant increase in adiponectin levels in obese sedentary males following a short-term exercise training program (approximately 1 week). On the contrary, Ferguson et al (2004) reported no effect of a submaximal aerobic exercise bout on adiponectin concentration in young healthy normal weight individuals.…”

Section: Discussionmentioning

confidence: 98%

“…There are studies which have reported no effect of acute exercise on adiponectin levels in healthy, normal weight individuals (Ferguson et al 2004;Kraemer et al 2003;Punyadeera et al 2005). On the other hand, Jurimae et al (2005) reported a significant decrease immediately following exercise and significant increase 30 min post-exercise in healthy normal weight individuals, whereas Kriketos et al (2004) reported that very short exercise training (approximately 1 week) resulted in increased levels of adiponectin and insulin sensitivity in obese individuals without a concomitant body weight loss. It is worth mentioning, that none of the acute studies have examined the probable prolonged effect of exercise on adiponectin levels and its relationship with insulin sensitivity.…”

Section: Introductionmentioning

confidence: 99%

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The effects of acute exercise on serum adiponectin and resistin levels and their relation to insulin sensitivity in overweight males

et al. 2006

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The purpose of this study was to investigate the effects of a submaximal aerobic exercise bout on adiponectin and resistin levels as well as insulin sensitivity, until 48 h post-exercise in healthy overweight males. Nine subjects performed an exercise bout at an intensity corresponding to approximately 65% of their maximal oxygen consumption for 45 min. Adiponectin, resistin, cortisol, insulin, glucose and insulin sensitivity were measured prior to exercise, immediately after exercise as well as 24 and 48 h after exercise. Data were analyzed using repeated measures ANOVA while Pearson's correlations were performed to identify possible relationship among the assessed variables. There were no significant differences for adiponectin (lg ml À1 ) [pre Insulin sensitivity increased and insulin concentration decreased significantly only immediately after exercise. Furthermore, no significant correlations were observed among the variables assessed except for the expected between insulin level and insulin sensitivity. These results indicate that a submaximal aerobic workout does not result in significant changes in adiponectin and resistin up to 48 h post-exercise. Furthermore, it appears that adiponectin or resistin is not associated with insulin sensitivity.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

The effects of acute exercise on serum adiponectin and resistin levels and their relation to insulin sensitivity in overweight males

et al. 2006

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“…We observed no consistent association between physical activity and adiponectin, although paradoxically levels were significantly reduced in the vigorously active group. Although it has been suggested that exercise may increase adiponectin levels, clinical studies on the effects of exercise training have been conflicting 41,42 and findings in population-based studies are inconsistent. 19,21 Insulin resistance and the metabolic syndrome Strong associations were seen between adiponectin and HOMA-IR after adjustment for waist circumference and the magnitude of correlation was similar to that seen for BMI.…”

Section: Discussionmentioning

confidence: 99%

Associations of adiponectin with metabolic and vascular risk parameters in the British Regional Heart Study reveal stronger links to insulin resistance-related than to coronory heart disease risk-related parameters

et al. 2007

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Background and aim: Adiponectin is considered by many to be part of the 'common soil' linking type 2 diabetes and coronary heart disease (CHD). We examined the relationship between adiponectin and insulin resistance, metabolic, inflammatory and haemostatic risk factors and hepatic function. Methods and results: The study was carried out in 3640 non-diabetic men aged 60-79 years drawn from general practices in 24 British towns and who were not on warfarin. Adiponectin was associated with waist circumference (inversely), alcohol intake (positively) and physical activity (nonlinearly); no association was seen with cigarette smoking, prevalent CHD or stroke. After adjustment for these factors, adiponectin was significantly inversely associated with insulin resistance, triglyceride, C-reactive protein (but not interleukin 6), tissue plasminogen activator and alanine aminotransferase and positively associated with highdensity lipoprotein cholesterol (HDL-cholesterol) and Factor VIII, factors associated with diabetes. No association was seen with cholesterol, smoking, systolic blood pressure or coagulation factors. Risk of the metabolic syndrome decreased significantly with increasing adiponectin. Conclusion: Adiponectin is inversely associated with factors strongly associated with the development of diabetes. Limited associations with the established major risk factors for CHD suggest adiponectin may be a stronger marker of risk for diabetes than for CHD.

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“…It has been shown that basal adiponectin concentration was not altered after longterm exercise [10][11][12][13][14]. In contrast, Kriketos et al [15] recently reported that fasting adiponectin levels increased by 260% above baseline values after 2-3 bouts of low to moderate intensity exercise. Although Hara et al [13] performed a study on young obese men, no reports have been available on adiponectin concentra-tions in obese young women during prolonged and moderate intensity exercise.…”

mentioning

confidence: 96%

“…Several studies exploring the effects of exercise on circulating adiponectin levels have resulted in inconsistent findings [10][11][12][13][14][15]. It has been shown that basal adiponectin concentration was not altered after longterm exercise [10][11][12][13][14].…”

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confidence: 99%

Effect of Exercise on Circulating Adipokine Levels in Obese Young Women

2006

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Abstract. We studied the effect of exercise on circulating adipokine, high sensitivity C-reactive protein (hs-CRP), and metabolic parameters in obese young women. Ninety-six healthy Japanese young female students aged 18-23 years were studied. The longitudinal intervention study of a 7-month exercise training program (30-60 min/day, 60-70% HRreserve, 200-400 kcal, 4-5 days/week) was performed in eight obese female students (BMI ³25 kg/m 2 ). Eight control female students (mean BMI = 22 kg/m 2 ) were included in the follow-up study. Body weight, body mass index (BMI), percentage of body fat (%Fat), body fat mass, lean body mass, health-promoting lifestyle profile-scale (L-scale), Vo 2 max (maximal oxygen uptake), hs-CRP, lipids, insulin homeostasis model assessment (HOMA-R), fasting levels for circulating adiponectin, leptin, and TNF-a, were measured before and after the exercise program. In obese subjects, body weight, BMI, %Fat, body fat mass, lean body mass, hs-CRP, leptin, and TNF-a were significantly higher, and L-scale and adiponectin were lower than those in control subjects. In obese subjects, exercise decreased body weight, BMI, %Fat, body fat mass, lean body mass, hs-CRP, leptin, and TNF-a, and increased L-scale, Vo 2 max, HDL-cho, and adiponectin. It was concluded that changes in circulating adipokine levels are involved in the improvement of the metabolic state by exercise and may be useful markers for evaluation and prescription of exercise.

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Exercise Increases Adiponectin Levels and Insulin Sensitivity in Humans

Abstract: Characteristics of patients with type 2 diabetes in Mexico: results from a large populationbased nationwide survey.

Cited by 192 publications

References 8 publications

The effects of acute exercise on serum adiponectin and resistin levels and their relation to insulin sensitivity in overweight males

The effects of acute exercise on serum adiponectin and resistin levels and their relation to insulin sensitivity in overweight males

Associations of adiponectin with metabolic and vascular risk parameters in the British Regional Heart Study reveal stronger links to insulin resistance-related than to coronory heart disease risk-related parameters

Effect of Exercise on Circulating Adipokine Levels in Obese Young Women

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