Exercise in frail elderly men decreases natural killer cell activity

Rincón, Hernán G.; Solomon, George F.; Benton, Donna; Rubenstein, Laurence Z.

doi:10.1007/bf03339564

Cited by 12 publications

(19 citation statements)

References 19 publications

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“…The duration per session ranged from 1084 to 90 minutes [57–59, 80, 96], and the majority of the studies included interventions that lasted either 45 minutes/session (6 studies) [22–29, 45, 46, 49–51, 79, 83, 95] or 60 minutes/session (12 studies) [41–44, 52–56, 61, 62, 66, 67, 71, 74, 78, 89, 91]. Fourteen studies did not report the duration of the exercise sessions [38–40, 64, 65, 68, 70, 72, 73, 76, 81, 82, 84, 87, 90, 92].…”

Section: Resultsmentioning

confidence: 99%

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The Effectiveness of Exercise Interventions for the Management of Frailty: A Systematic Review

Theou

Stathokostas

Roland

et al. 2011

Journal of Aging Research

483

387

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This systematic review examines the effectiveness of current exercise interventions for the management of frailty. Eight electronic databases were searched for randomized controlled trials that identified their participants as “frail” either in the title, abstract, and/or text and included exercise as an independent component of the intervention. Three of the 47 included studies utilized a validated definition of frailty to categorize participants. Emerging evidence suggests that exercise has a positive impact on some physical determinants and on all functional ability outcomes reported in this systematic review. Exercise programs that optimize the health of frail older adults seem to be different from those recommended for healthy older adults. There was a paucity of evidence to characterize the most beneficial exercise program for this population. However, multicomponent training interventions, of long duration (≥5 months), performed three times per week, for 30–45 minutes per session, generally had superior outcomes than other exercise programs. In conclusion, structured exercise training seems to have a positive impact on frail older adults and may be used for the management of frailty.

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Section: Resultsmentioning

confidence: 99%

“…Exercise improved immune status in two studies [29, 40], did not have an impact on two other studies [70, 83], and had a negative impact (decreasing natural killer cell activity) in one study [61]. IGF-I improved in one of two studies where this outcome was measured [51].…”

Section: Resultsmentioning

confidence: 99%

The Effectiveness of Exercise Interventions for the Management of Frailty: A Systematic Review

Theou

Stathokostas

Roland

et al. 2011

Journal of Aging Research

483

387

View full text Add to dashboard Cite

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“…Rall et al (1996) found no changes in PBMNC subsets, production of IL-1β, TNF-α, ΙL-6, IL-2 or prostaglandin (PG)E 2 production, lymphocyte proliferation or delayedtype hypersensitivity response after 12 weeks of highintensity progressive-resistance training in eight healthy young subjects (22-30 years) and eight healthy elderly subjects (65-80 years). Rincon et al (1996) investigated the effect of an exercise intervention programme of 60 min three times weekly for 3 months in six frail men aged 70 years or more who were at risk of a fall but not suffering from serious medical problems compared with seven controls having no intervention. Cytotoxic activity of NK cells significantly decreased during the course of the study, suggesting that exercise was having an adverse effect on NK activity in the very frail elderly.…”

Section: Chronic Exercise Effects In the Elderlymentioning

confidence: 99%

Exercise and immune function: effect of ageing and nutrition

et al. 1999

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fax +45 3545 6648, email bkp@rh.dk Strenuous exercise is followed by lymphopenia, neutrophilia, impaired natural immunity, decreased lymphocyte proliferative responses to mitogens, a low level of secretory immunoglobulin A in saliva, but high circulating levels of pro-and anti-inflammatory cytokines. These exercise-induced immune changes may provide the physiological basis of altered resistance to infections. The mechanisms underlying exercise-induced immune changes are multifactorial and include neuroendocrinological and metabolic mechanisms. Nutritional supplementation with glutamine abolishes the exercise-induced decline in plasma glutamine, but does not influence post-exercise immune impairment. However, carbohydrate loading diminishes most exercise effects of cytokines, lymphocyte and neutrophils. The diminished neutrophilia and elastase (EC 3.4.21.37) responses to eccentric exercise in elderly subjects were enhanced to levels comparable with those of young subjects by fish oil or vitamin E supplements. However, although vitamin C supplementation may diminish the risk of contracting an infection after strenuous exercise, it is not obvious that this effect is linked to an effect of vitamin C on exercise-induced immune changes. In conclusion, it is premature to make recommendations regarding nutritional supplementation to avoid post-exercise impairment of the immune system.

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“…Most of these studies, however, were carried out on elderly populations with a relatively young age range [14][15][16] and investigated NK activity in relation to a limited number of biological parameters [5,6,17] more or less in isolation from each other. Other investigations were performed on cohorts with different racial characteristics and living habits (such as Japanese subjects) [18], very different from north-western populations.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D, thyroid hormones and muscle mass influence natural killer (NK) innate immunity in healthy nonagenarians and centenarians

Mariani¹,

Ravaglia

Forti

et al. 1999

Clinical and Experimental Immunology

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Increasing evidence has demonstrated that the immune system closely interacts with other physiological systems, whose communications are mediated by circulating cytokines and hormones. The aim of our study was to test whether the number and cytolytic activity of NK cells in a group of relatively healthy Italian nonagenarians and centenarians were affected by the modifications of endocrine, metabolic and functional parameters that occur during ageing. Because of the extreme age of the study population, a cross-sectional analysis was performed. This study revealed that the group of oldest subjects with the highest number of NK cells and the best preserved cytolytic function also presented a preserved metabolism of thyroid hormones and vitamin D and integrity of muscle mass. In fact, the NK cell number and/or cytolytic activity of healthy subjects > 90 years old was positively associated with serum levels of vitamin D, while T3, FT4, i-PTH hormones and lean body mass were associated only with NK cell number. In conclusion, our results stress the paramount importance of nutritional evaluation in the clinical assessment of elderly people.

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Exercise in frail elderly men decreases natural killer cell activity

Cited by 12 publications

References 19 publications

The Effectiveness of Exercise Interventions for the Management of Frailty: A Systematic Review

The Effectiveness of Exercise Interventions for the Management of Frailty: A Systematic Review

Exercise and immune function: effect of ageing and nutrition

Vitamin D, thyroid hormones and muscle mass influence natural killer (NK) innate immunity in healthy nonagenarians and centenarians

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