Exercise improves learning and memory impairments in sleep deprived female rats

Saadati, Hakimeh; Esmaeili‐Mahani, Saeed; Esmaeilpour, Khadijeh; Nazeri, Masoud; Mazhari, Shahrzad; Sheibani, Vahid

doi:10.1016/j.physbeh.2014.10.006

Cited by 46 publications

(39 citation statements)

References 70 publications

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“…The ability of mice to retain novel information and consolidate memory was interrupted by SD (40). Based on the results of previous studies, it seems that ovariectomized (OVX) female rats are more susceptible than intact animals to the harmful effects of SD on cognitive functions (6,13,18,19). Additionally, these finding are compatible with those of human studies indicating that menopausal females were susceptible to negative effects of sleep loss (41).…”

Section: Sleep Deprivation and Cognitive Disorderssupporting

confidence: 59%

“…Several experiments established the significant correlation between REM sleep and cognitive performances in male and female animals. Animals that experienced SD indicated significant cognitive impairments in various paradigms such as radial ram water maze (16), Morris water maze (MWM) (6,17,19), and the plus-maze discriminative avoidance task (39). The negative effects of SD on emotional memory of mice were previously recognized (8).…”

Section: Sleep Deprivation and Cognitive Disordersmentioning

confidence: 99%

“…It seems that sleep is the main factor in the acquisition and consolidation of memory (4,5). Therefore, sleep deprivation (SD) impairs spatial (6,7), emotional (8), and working memories (9), and augments anxiety like behaviors (10). As a result, hippocampus is very sensitive to sleep loss (11,12).…”

Section: Introduction and Statement Of The Problemmentioning

confidence: 99%

“…Other studies demonstrated that generation and preservation of long-term potentiating (LTP) and spatial learning and memory are impaired by sleep deprivation. Sleep deprivation also decreases trophic factors such as brain derived neurotrophic factors (BDNF) level in the hippocampus of male (16) and female (6,13,(17)(18)(19) rats.…”

Section: Introduction and Statement Of The Problemmentioning

confidence: 99%

“…Exercise can enhance cognitive performance and cell proliferation in the hippocampus (29). ments (6) and improve LTP (13) in neurodegenerative diseases and estrogen deprivation periods (31).Other investigations revealed that regular activity can prevent the SDinduced impairments of cognitive function, synaptic plasticity, and signaling molecules in the hippocampus of male (16) and female rats (6,13,18,19).…”

Section: Introduction and Statement Of The Problemmentioning

confidence: 99%

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A Review of Protective Effects of Exercise on Cognitive Impairments Induced by Sleep Deprivation in Female Rats

Saadati

2017

Arch Neurosci

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Sleep is an important factor in memory consolidation and brain health. In addition, sleep disorder is a common complaint among females in comparison with males. In menopausal females, to relieve sleep disturbances and other menopausal symptoms, hormone therapy may be used. Furthermore, although estrogen had helpful effects on the brain performance, hormone replacement therapy augmented unfavorable cardiovascular and oncological side effects. It is implied that exercise is a powerful nonpharmacological intervention that can develop the cognitive performances. The current study used the behavioral, physiological, and molecular evidence supporting these views.

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Section: Sleep Deprivation and Cognitive Disorderssupporting

confidence: 59%

Section: Sleep Deprivation and Cognitive Disordersmentioning

confidence: 99%

Section: Introduction and Statement Of The Problemmentioning

confidence: 99%

Section: Introduction and Statement Of The Problemmentioning

confidence: 99%

Section: Introduction and Statement Of The Problemmentioning

confidence: 99%

See 3 more Smart Citations

A Review of Protective Effects of Exercise on Cognitive Impairments Induced by Sleep Deprivation in Female Rats

Saadati

2017

Arch Neurosci

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Sex‐dependent effects of postweaning exposure to an enriched environment on novel objective recognition memory and anxiety‐like behaviors: The role of hippocampal BDNF level

Sakhaie

Sadegzadeh

Mohammadnia

et al. 2020

Intl J of Devlp Neuroscience

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Exposure to enriched environment (EE) has been indicated to enhance cognitive functions, hippocampal neural plasticity, neurogenesis, long‐term potentiation, and levels of the brain‐derived neurotrophic factor (BDNF) in laboratory animals. Also, studies on the sex‐dependent effects of exposure to EE during adolescence on adult cognitive functions are less. This is important because the beneficial effects of EE may be predominant in the adolescence stage. Therefore, the present study was designed to compare the effects of EE during adolescence (PND21‐PND60) on novel objective recognition memory (NORM), anxiety‐like behaviors, and hippocampal BDNF mRNA level in the adult male and female rats. Assessment of NORM and anxiety‐like behaviors has been done by novel objective recognition task, open field (OF), and elevated plus maze (EPM), respectively. The expression of BDNF mRNA level was also evaluated by quantitative RT‐PCR. Our findings demonstrated that housing in the EE during adolescence improves NORM in adult male rats. Also, exposure to EE during adolescence had a different effect on anxiety‐like behaviors in both sexes. Additionally, our results indicated an augmented BDNF level in the hippocampus of male and female rats. In conclusion, adolescent exposure to EE has sex‐dependent effects on cognitive functions and anxiety‐like behaviors and increases BDNF mRNA expression in the hippocampus of both male and female rats; thus, BDNF is an important factor that can mediate the beneficial effects of EE and running exercise on cognitive functions and psychiatric traits.

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Adolescent enriched environment exposure alleviates cognitive impairments in sleep‐deprived male rats: Role of hippocampal brain‐derived neurotrophic factor

Ghaheri

Panahpour

Abdollahzadeh

et al. 2022

Intl J of Devlp Neuroscience

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Developmental life experience has long-lasting influences on the brain and behavior. The present study aims to examine the long-term effects of the enriched environment (EE), which was imposed during the adolescence period of life, on their passive avoidance and recognition memories as well as anxiety-like behaviors and hippocampal brain-derived neurotrophic factor (BDNF) levels, in sleep-deprived male rats.In the present study, the male pups were separated from their mothers in postnatal day 21 (PND21) and were housed in the standard or EE for 40 days. In PND 61, the rats were allocated in four groups: control, SD (sleep deprivation), EE, and EE + SD groups. SD was induced in rats by a modified multiple platform model for 24 h. Open field, novel object recognition memory, and passive avoidance memory tests were used to examine behavior and cognitive ability. The expression of hippocampal BDNF levels was determined by PCR.The results revealed that SD increased anxiety-like behaviors and impaired cognitive ability, while adolescent EE housing alleviated these changes. In addition, EE reversed SD-induced changes in hippocampal BDNF level. We also demonstrated that EE not only has beneficial effects on the cognitive functions of normal rats but also declined memory deficits induced by SD.In conclusion, our results suggest that housing in EE during the adolescence period of life reduces cognitive impairment induced by SD. The increase of the BDNF level in the hippocampus is a possible mechanism to alleviate cognitive performance in sleep-deprived rats.

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Exercise improves learning and memory impairments in sleep deprived female rats

Cited by 46 publications

References 70 publications

A Review of Protective Effects of Exercise on Cognitive Impairments Induced by Sleep Deprivation in Female Rats

A Review of Protective Effects of Exercise on Cognitive Impairments Induced by Sleep Deprivation in Female Rats

Sex‐dependent effects of postweaning exposure to an enriched environment on novel objective recognition memory and anxiety‐like behaviors: The role of hippocampal BDNF level

Adolescent enriched environment exposure alleviates cognitive impairments in sleep‐deprived male rats: Role of hippocampal brain‐derived neurotrophic factor

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