Exercise improves hippocampal estrogen and spatial memory of ovariectomized rats

Kaidah, Siti; Soejono, Sri Kadarsih; Partadiredja, Ginus

doi:10.4149/bll_2016_019

Cited by 17 publications

(11 citation statements)

References 46 publications

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“…In addition, the present study didn’t show any significant change in working and reference memory assessed by MWM after aerobic exercise in OVX groups with different status of Vit D. However study carried out by Kaidah et al [ 58 ] showed contradictory result [ 58 ]. Inconsistency might be related to difference in exercise protocols which consisted of five times per week for 12 weeks in ovariectomized rats in their work [ 58 ].…”

Section: Discussioncontrasting

confidence: 72%

Vitamin D is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized rats

Babaei

Shirkouhi

Hoseini

et al. 2017

Diabetol Metab Syndr

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PurposeHere, we studied the beneficial effects of aerobic exercise on metabolic syndrome components, cognitive performance, brain derived neurotrophic factor (BDNF) and irisin in ovariectomized rats with different serum vitamin D (Vit D) status.MethodsEighty female wistar rats were divided into 2 groups of sham operated (sham, n = 8), and ovariectomized (OVX, n = 72). Then OVX were divided into 9 groups of receiving combination of exercise protocol with low dose of Vit D (OVX + EXE + LD), high dose of Vit D (OVX + EXE + HD), Vit D deficiency (OVX + EXE − D), and (OVX + EXE + Veh). Also non exercised groups of OVX receiving high dose of Vit D (OVX + HD), low dose of Vit D (OVX + LD), Vit D deficiency (OVX − D), and Veh (OVX + Veh) were included. After 2 months of related interventions, spatial memory was assessed using Morris water maze (MWM), and then metabolic syndrome components were measured.ResultsHigh dose of Vit D supplementation showed significant reduction in weight (p = 0.001), lipid profiles (p = 0.001), visceral fat (p = 0.001) and waist circumference (p = 0.001) regardless of exercising or not, with no change in cognitiive function. Serum BDNF level was significantly higher in Vit D deficient group (p = 0.001), and was decreased in the OVX + HD. In contrary, irisin did not show any significant relationship with serum concentration of Vit D, while it was significantly elevated in the exercised groups compared with non-exercised counterparts.ConclusionVit D insufficiency deteriorates metabolic syndrome components, and elevates serum BDNF as a compensatory metabotropic factor, and further supplementation significantly attenuates these components parallel with reduction in BDNF. In addition, aerobic exercise successfully induces various metabolic benefits, provided optimum serum level of Vit D.

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Section: Discussioncontrasting

confidence: 72%

Vitamin D is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized rats

Babaei

Shirkouhi

Hoseini

et al. 2017

Diabetol Metab Syndr

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“…Unlike controls, training reversed cell death in LDL-OT group significantly, approaching its rate than sedentary control group (CS). Kaidah et al 30 also verified this action of physical activity in the hippocampus of ovariectomized rats trained. Comparing the wild groups and knockout, it can infer that the effect of physical activity on cell death may depend on the oxidative stress of the tissue level.…”

Section: Discussionmentioning

confidence: 86%

Effects of Physical Training on the Myocardium of Female LDL Knockout Ovariectomized Mice

Brianezi

Marques

Cardoso

et al. 2017

Rev Bras Med Esporte

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Introduction: The emergence of coronary heart disease increases with menopause, physical inactivity and with dyslipidemia. It is known that physical training promotes the improvement of cardiovascular functions. Objective: The purpose of this study was to investigate the effects of aerobic physical training on the left ventricle in female LDL knockout ovariectomized mice. Methods: Thirty animals were divided into 6 groups (n=5), namely, sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariectomized; sedentary ovariectomized; and trained ovariectomized. We analyzed the mean nuclear volume parameters, the cross sectional area of the myocytes, the apparent density of the capillaries, interstitium, myocytes and collagen fibers. Results: The results show that for the density of the number of nuclei, the physical activity decreased to values close to the ovariectomized control group. Regarding the mean nuclear volume and the average area of myocytes, training and ovariectomy promoted the elevation of these values but hypercholesterolemia was lower. the volume density of myocytes, hypercholesterolemia showed an increase of these values as well as the training. There was no change in the volumetric density of the capillaries and the density of collagen fibers. The training caused the decrease in the density of the interstitial volume, and the hypercholesterolemia changed to a smaller one than the control group. Conclusion: We concluded that the moderate aerobic activity or the training time used in our study were not sufficient to generate significant alterations in the hypercholesterolemic group.

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“…Estrogen is a steroid hormone mainly produced by the ovaries and primarily known for its role in the achievement of sexual maturation and fertility. Apart from its commonly known roles, estrogen also stimulates neuroprotective mechanisms that lead to the improvement of both neuronal health and spatial memory retention (8,16). These neuroprotective properties of estrogen are typically facilitated by its most biologically active form, estradiol (17,18).…”

Section: Estrogen and The Brainmentioning

confidence: 99%

Exercise and estrogen: common pathways in Alzheimer's disease pathology

Bagit

Hayward

MacPherson

2021

American Journal of Physiology-Endocrinology and Metabolism

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Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by progressive declines in cognitive function. Current epidemiological data indicates significant sex-linked disparities, where females have a higher risk of developing AD compared to male counterparts. This disparity necessitates further investigations to uncover the pathological and molecular factors influencing these sex differences. Although the underlying pathways behind this observed disparity remain elusive, recent research points to menopausal estrogen loss as a potential factor. Estrogen holds a significant role in APP processing as well as overall neuronal health through the regulation of brain derived neurotrophic factor (BDNF) - a factor that is also reduced in post-menopausal women. BDNF is a known contributor to neuronal health, and its reduced expression is typically linked to AD disorders. Exercise is known to increased BDNF and may provide an accessible activity for post-menopausal women to reduce their risk of AD. This review aims to discuss the relationship between estrogen, exercise, and BDNF in AD pathology.

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Exercise improves hippocampal estrogen and spatial memory of ovariectomized rats

Cited by 17 publications

References 46 publications

Vitamin D is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized rats

Vitamin D is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized rats

Effects of Physical Training on the Myocardium of Female LDL Knockout Ovariectomized Mice

Exercise and estrogen: common pathways in Alzheimer's disease pathology

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