Exercise for Osteoarthritis: A Literature Review of Pathology and Mechanism

Kong, Hui; Wang, Xueqiang; Zhang, Xinan

doi:10.3389/fnagi.2022.854026

Cited by 31 publications

(29 citation statements)

References 225 publications

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“…In addition, it has been found that older adults suffer from chronic diseases of hyperglycemia, and a fixed number of walks per day for many years can effectively control blood glucose [ 72 ]. Some people may question whether frequent walking among older adults will affect the joints, but studies have shown that walking in older adults has a positive lubricating and protective effect on bone joints [ 73 , 74 , 75 ]. Since walking has the effect of promoting health in older adults, how many steps should older adults walk every day?…”

Section: Discussionmentioning

confidence: 99%

Promoting Healthy Behaviors in Older Adults to Optimize Health-Promoting Lifestyle: An Intervention Study

Chia

Huang²,

Huang

et al. 2023

IJERPH

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Introduction: Exercise intervention is the easiest and most effective way to promote human health. This study combined technology and exercise to improve the health behavior of the older adults through a physical activity intervention and to enhance a health-promoting lifestyle. Materials and methods: A quasi-experimental research method was used to openly recruit 120 healthy male and female older adults over 65 years old (average age of males: 71.6 ± 1.25 years; average age of females: 72.3 ± 1.28 years), all of whom wore smart bracelets. The participants were monitored by special personnel during the same period of walking every Monday to Friday. All participants recorded their daily steps, distance walked, and calorie consumption data for a period of 8 weeks. Results: After 8 weeks of walking, all participants showed a positive medium–high correlation of various factors between healthy behaviors and the health-promoting lifestyle scales. In the post-tests of each factor of two scales, males had the highest correlation between regular physical activity and physical activity, and females had the highest correlation between regular physical activity and social support. The variabilities in the explanatory power of the health behaviors of males and females on the health-promoting lifestyle were R2 = 70.9% (p < 0.01) and R2 = 74.1% (p < 0.01), indicating that the variables of healthy behaviors have a positive effect on health-promoting lifestyles in male and female older adults. Conclusions: Walking interventions positively affect the health behaviors of older adults and encourage health-promoting lifestyles. The value of this study is in its contribution to health promotion and public health recommendations for older adults.

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Section: Discussionmentioning

confidence: 99%

Promoting Healthy Behaviors in Older Adults to Optimize Health-Promoting Lifestyle: An Intervention Study

Chia

Huang²,

Huang

et al. 2023

IJERPH

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“…Under normal healthy conditions, the streaming potential is apparently able to stimulate the biogenesis of cartilage and counter the degradation by wear and tear in a continuous cycle. One of the current recommendations for people at risk of developing OA is exercise ( Roos and Dahlberg, 2005 ; Racunica et al, 2007 ; Ravalli et al, 2019 ; Kong et al, 2022 ). Exercise may exert this effect by enhancing the magnitude of streaming potentials thereby stimulating chondrocytes to produce new ECM.…”

Section: Cartilage In a See/saw Mode A Cliffhanger Towards Osteoarthr...mentioning

confidence: 99%

A new look at osteoarthritis: Threshold potentials and an analogy to hypocalcemia

Gelder

Audenaert²,

Calders³

et al. 2023

Front. Aging

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Cartilage is a tissue that consist of very few cells embedded in a highly negatively charged extracellular matrix (ECM). This tissue is dealing with several electrical potentials which have been shown to control the production of ECM. Cartilage is present at joints and is constantly prone to degradation. Failing to repair the damage will result in the occurrence of osteoarthritis (OA). This perspective aims to link biophysical insights with biomolecular research in order to provide an alternative view on the possible causes of OA. Firstly, we hypothesize the existence of a threshold potential, which should be reached in order to initiate repair but if not met, unrepaired damage will evolve to OA. Measurements of the magnitude of this threshold electrical potential would be a helpful diagnostic tool. Secondly, since electrical potential alterations can induce chondrocytes to synthesize ECM, a cellular sensor must be present. We here propose an analogy to the hypocalcemia ‘unshielding’ situation to comprehend electrical potential generation and explore possible sensing mechanisms translating the electrical message into cellular responses. A better understanding of the cellular voltage sensors and down-stream signalling mechanisms may lead to the development of novel treatments for cartilage regeneration.

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“…The cartilage can therefore buffer the mechanical stress between the tibia and femur during exercise and decrease friction [1]. Aging and aberrant mechanical load-caused anterior cruciate ligament (ACL) rupture will lead to the cell loss of chondrocytes and extracellular matrix (ECM) degradation in articular cartilage and further cause osteoarthritis (OA) [2,3]. Once OA occurs, inflammatory factors are highly expressed and pervasive in the synovial fluid, and then the matrix metalloproteinases 2 of 18 (MMPs) is activated, further adding to the degradation of ECM [4,5].…”

Section: Introductionmentioning

confidence: 99%

Dehydrocorydaline Accelerates Cell Proliferation and Extracellular Matrix Synthesis of TNFα-Treated Human Chondrocytes by Targeting Cox2 through JAK1-STAT3 Signaling Pathway

Sha

Zhang

Chen

et al. 2022

IJMS

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Osteoarthritis (OA) causes severe degeneration of the meniscus and cartilage layer in the knee and endangers joint integrity and function. In this study, we utilized tumor necrosis factor α (TNFα) to establish in vitro OA models and analyzed the effects of dehydrocorydaline (DHC) on cell proliferation and extracellular matrix (ECM) synthesis in human chondrocytes with TNFα treatment. We found that TNFα treatment significantly reduced cell proliferation and mRNA and protein expression levels of aggrecan and type II collagen, but caused an increase in mRNA and protein expression levels of type I collagen, matrix metalloproteinase 1/13 (MMP1/13), and prostaglandin-endoperoxide synthase 2 (PTGS2, also known as Cox2) in human chondrocytes. DHC significantly promoted the cell activity of normal human chondrocytes without showing cytotoxity. Moreover, 10 and 20 μM DHC clearly restored cell proliferation, inhibited mRNA and protein expression levels of type I collagen, MMP 1/13, and Cox2, and further increased those of aggrecan and type II collagen in the TNFα-treated human chondrocytes. RNA transcriptome sequencing indicated that DHC could improve TNFα-induced metabolic abnormalities and inflammation reactions and inhibit the expression of TNFα-induced inflammatory factors. Furthermore, we found that the JAK1-STAT3 signaling pathway was confirmed to be involved in the regulatory effects of DHC on cell proliferation and ECM metabolism of the TNFα-treated human chondrocytes. Lastly, to explore the effects of DHC in vivo, we established an anterior cruciate ligament transection (ACLT)-stimulated rat OA model and found that DHC administration significantly attenuated OA development, inhibited the enzymatic hydrolysis of ECM, and reduced phosphorylated JAK1 and STAT3 protein expression in vivo after ACLT for 6 weeks. These results suggest that DHC can effectively relieve OA progression, and it has a potential to be utilized for the clinical prevention and therapy of OA as a natural small molecular drug.

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Exercise for Osteoarthritis: A Literature Review of Pathology and Mechanism

Cited by 31 publications

References 225 publications

Promoting Healthy Behaviors in Older Adults to Optimize Health-Promoting Lifestyle: An Intervention Study

Promoting Healthy Behaviors in Older Adults to Optimize Health-Promoting Lifestyle: An Intervention Study

A new look at osteoarthritis: Threshold potentials and an analogy to hypocalcemia

Dehydrocorydaline Accelerates Cell Proliferation and Extracellular Matrix Synthesis of TNFα-Treated Human Chondrocytes by Targeting Cox2 through JAK1-STAT3 Signaling Pathway

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