Exercise, fitness, and cardiovascular disease risk in type 2 diabetes and the metabolic syndrome

Duncan, Glen E.

doi:10.1007/s11892-006-0048-1

Cited by 59 publications

(47 citation statements)

References 58 publications

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“…Regular exercise has long been associated with a reduced risk of obesity, type 2 diabetes, and cardiovascular disease (23,24). Furthermore, there is a growing body of literature that implicates lifestyle change, specifically decreased physical activity, as a contributor to the increase in asthma prevalence and severity (25).…”

Section: Discussionmentioning

confidence: 99%

Effect of exercise training on plasma visfatin and eotaxin levels

Choi

Kim²,

Cho³

et al. 2007

eur j endocrinol

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Objective: Visfatin, a novel adipokine, was revealed to be associated with obesity and to have insulinmimetic effect. Eotaxin, which is an important chemokine in asthma, was recently reported to be associated with obesity in mice and humans. We evaluated the effect of exercise training on plasma visfatin and eotaxin levels in association with cardiovascular risk factors. Design: Forty-eight non-diabetic Korean women were evaluated before and after a 12 week exercise program including aerobic exercise (45 min/session, 300 Kcal/day) and muscle strength training (20 min/session, 100 Kcal/day) five times per week. Results: Plasma visfatin concentrations were elevated in obese subjects (body mass index, BMIR25 kg/m 2 ) when compared with non-obese subjects (16.4G13.4 ng/ml vs 7.7G 5.2 ng/ml, PZ0.006), and eotaxin concentrations were elevated in subjects with central obesity (waist circumference, WCR80 cm) when compared with those without central obesity (73.6G17.8 pg/ml vs 64.2G4.2 pg/ml, PZ0.005). In multiple regression analyses, visfatin levels were associated with BMI (R 2 Z0.255) and eotaxin levels were associated with WC and body weight (R 2 Z0.307). After the exercise program, body weight, blood pressure, fasting glucose, and insulin resistance of participants were decreased. Furthermore, plasma visfatin levels were significantly decreased from 13.6G12.0 to 7.7G7.9 ng/ml (PZ0.026) and eotaxin levels were reduced from 72.0G16.7 to 66.9G14.2 pg/ml (PZ0.018). Conclusions: Exercise training with weight loss induced a significant reduction of plasma visfatin and eotaxin levels in non-diabetic Korean women.European Journal of Endocrinology 157 437-442

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Section: Discussionmentioning

confidence: 99%

Effect of exercise training on plasma visfatin and eotaxin levels

Choi

Kim²,

Cho³

et al. 2007

eur j endocrinol

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“…All these conditions, characterized by insulin resistance, are associated with increased cardiovascular morbidity and mortality 9) . Lower cardiorespiratory fitness and related low physical activity are frequently observed in subjects with metabolic syndrome 10,11) . Lifestyle modifications such as appropriate dietary intake and physical exercise starting early in life definitely improve some of these CVD risk factors.…”

Section: Introductionmentioning

confidence: 99%

Cardiorespiratory Fitness and Metabolic Markers in Healthy Young Adult Men

et al. 2011

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Abstract.[Purpose] The purpose of this study was to clarify the relationship between cardiorespiratory fitness and metabolic markers, including leptin, in healthy young adults.[Subjects] The subjects were 51 healthy young men (mean age, 21.6 years; range, 18-31 years).[Methods] Ventilatory threshold and maximal oxygen uptake were measured on a cycle ergometer. The metabolic markers, HDL-cholesterol, triglyceride, fasting glucose, fasting insulin and leptin, were also measured, as well as and body composition, body height, body weight, percentage fat mass, waist circumference, and hip circumference. Blood pressure levels were recorded at rest.[Results] Our results show that lower cardiorespiratory fitness was significantly associated with higher storage of fat, lipid markers of developing atherosclerosis, and circulating leptin levels. Higher circulating leptin levels were also associated with metabolic risk markers such as obesity and insulin resistance.[Conclusion] Our results suggest that appropriate cardiorespiratory fitness may improve circulating metabolic markers even in healthy young men. It is therefore important that all persons should have high cardiorespiratory fitness from an early period of life for the effective prevention of cardiovascular disease.

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“…8 In this study we examine the effects of moderate intensity exercise on bladder function in diabetes. We hypothesize that moderate exercise improves diabetic bladder function in type 2 diabetes by reducing voiding frequency.…”

Section: Introductionmentioning

confidence: 99%