Effect of exercise training on plasma visfatin and eotaxin levels

Abstract

Objective: Visfatin, a novel adipokine, was revealed to be associated with obesity and to have insulinmimetic effect. Eotaxin, which is an important chemokine in asthma, was recently reported to be associated with obesity in mice and humans. We evaluated the effect of exercise training on plasma visfatin and eotaxin levels in association with cardiovascular risk factors. Design: Forty-eight non-diabetic Korean women were evaluated before and after a 12 week exercise program including aerobic exercise (45 min/session, 300 Kcal/day) and muscle strength training (20 min/session, 100 Kcal/day) five times per week. Results: Plasma visfatin concentrations were elevated in obese subjects (body mass index, BMIR25 kg/m 2 ) when compared with non-obese subjects (16.4G13.4 ng/ml vs 7.7G 5.2 ng/ml, PZ0.006), and eotaxin concentrations were elevated in subjects with central obesity (waist circumference, WCR80 cm) when compared with those without central obesity (73.6G17.8 pg/ml vs 64.2G4.2 pg/ml, PZ0.005). In multiple regression analyses, visfatin levels were associated with BMI (R 2 Z0.255) and eotaxin levels were associated with WC and body weight (R 2 Z0.307). After the exercise program, body weight, blood pressure, fasting glucose, and insulin resistance of participants were decreased. Furthermore, plasma visfatin levels were significantly decreased from 13.6G12.0 to 7.7G7.9 ng/ml (PZ0.026) and eotaxin levels were reduced from 72.0G16.7 to 66.9G14.2 pg/ml (PZ0.018). Conclusions: Exercise training with weight loss induced a significant reduction of plasma visfatin and eotaxin levels in non-diabetic Korean women.European Journal of Endocrinology 157 437-442

Single and Concurrent Effects of Endurance and Resistance Training on Plasma Visfatin, Insulin, Glucose and Insulin Resistance of Non-Athlete Men with Obesity

“…Lee et al (2010) reported that after twelve weeks of aerobic training on overweight subjects, there was desirable changes in body composition by reduced visfatin (29). Choi et al (2007) by investigating the effect of 12 weeks of combined endurance and resistance training, observed reduced visfatin (30). Seo et al (2011) also after twelve weeks of combined training on middle-aged women, reported reduced visfatin (31) which is consistent with the findings of the present study.…”

“…Some studies did not find any relationship between insulin resistance and visfatin (27,28), while in a study, Lee et al (2010) observed that doing 12 weeks aerobic training significantly reduced visfatin and improved insulin resistance index in obese women (29). On the other hand, no change in the level of plasma visfatin have been reported after aerobic training (30).…”

Impact of metformin treatment and swimming exercise on visfatin levels in high-fat-induced obesity rats

“…In addition, exercise training that resulted in weight loss induced significant reductions in plasma visfatin in young, overweight Korean women (27). Visfatin was also measured in response to acute exercise bouts where visfatin mRNA expression in SAT was found to be elevated threefold in the hours immediately after exercise (28).…”

Investigation of Plasma Visfatin Changes in Women with Type 2 Diabetes followed by Endurance, Resistance and Combined Exercise: The Role of Lipid Profile, Glycemic Indices and Insulin Resistance

“…In other study PVL among diabetic patients were same after 12 weeks of aerobic, resistance and combined exercises [19]. In contrast, one study has shown that exercise training with weight loss induced a significant reduction of PVL in non-diabetic Korean women [20]. Another research among obese females reported that PVL reduced after 12 weeks of combined training (aerobic-strength), this reduction was associated with a decrease in anthropometric variables and blood glucose levels [21].…”