Exercise Exacerbates the Transcriptional Profile of Hypoxia, Oxidative Stress and Inflammation in Rats with Adjuvant-Induced Arthritis

González-Chávez, Susana Aideé; Quiñonez-Flores, Celia María; Espino-Solís, Gerardo Pável; Vázquez-Contreras, José Angel; Pacheco‐Tena, César

doi:10.3390/cells8121493

Cited by 12 publications

(14 citation statements)

References 50 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17,18 Especially, studies have shown that embelin plays an important anti-inflammatory role by attenuating a variety of acute and chronic inflammation in the development of a variety of metabolic diseases. [19][20][21] Based on the perspective of embelin-induced antiinflammation and antioxidant effect, we were evaluated fabricating the embelin-loaded chitosan nanoparticles (CSembelin NPs) for immunopharmacological efficacy against adjuvant-induced arthritis (AIA) in rats and its relevant effects on immune responses.…”

Section: Introductionmentioning

confidence: 99%

“…Embelin, a main active constituent in the fruits of Embelia ribes Burm, has been approved by the United States Food and Drug Administration (US FDA), an administration for addressing the biochemical effects, such as antitumor, anti‐inflammatory, analgesic, antidiabetic, and antioxidant effects . Especially, studies have shown that embelin plays an important anti‐inflammatory role by attenuating a variety of acute and chronic inflammation in the development of a variety of metabolic diseases . Based on the perspective of embelin‐induced anti‐inflammation and antioxidant effect, we were evaluated fabricating the embelin‐loaded chitosan nanoparticles (CS‐embelin NPs) for immunopharmacological efficacy against adjuvant‐induced arthritis (AIA) in rats and its relevant effects on immune responses.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antiarthritic effect of chitosan nanoparticle loaded with embelin against adjuvant‐induced arthritis in Wistar rats

Cui

Sreeharsha

et al. 2020

IUBMB Life

View full text Add to dashboard Cite

Background Rheumatoid arthritis (RA) is associated with joint damage. Effectiveness of embelin has been established in a wide variety of inflammatory disorders, but its utility as a therapeutic agent is limited by its poor absorption, rapid metabolism, and fast systemic elimination. To apprehend these limitations, we propose to use highly bioavailable embelin‐loaded chitosan nanoparticles (CS‐embelin NPs) for the treatment of RA. Methods The rats were made arthritic using a subcutaneous injection with 0.1 ml complete Freund's adjuvant (CFA) into the footpad of the left hind paw. CS‐embelin NPs (25 and 50 mg/kg) was administered from day 15 to day 28 after adjuvant injection. After the experimental period, the animals were sacrificed and various biochemical markers were assessed. Results Arthritic score and paw swelling were significantly reduced after treatment with CS‐embelin NPs. Arthritis‐induced rats showed a significant increase in malondialdehyde (MDA) and nitric oxide (NO) with a concomitant reduction of antioxidants in the paw tissue. CS‐embelin NPs (25 and 50 mg/kg) reduced MDA and NO levels and restored antioxidant levels to normalcy by mitigating oxidative stress. The arthritic rats exhibited elevated tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6) and interleukin‐1beta (IL‐1β) serum concentrations, upregulated TNF‐ α and IL–6 protein levels and upregulated nuclear factor‐kB (NF‐kB) mRNA expression in paw tissues. Treatment with CS‐embelin NPs (25 and 50 mg/kg) significantly reduced serum levels and down‐regulated inflammatory markers to normalcy, dose‐dependently. Conclusion The results suggest that CS‐embelin NPs displayed a protective effect against adjuvant‐induced arthritis in rats mediated through antioxidant and anti‐inflammatory effects.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antiarthritic effect of chitosan nanoparticle loaded with embelin against adjuvant‐induced arthritis in Wistar rats

Cui

Sreeharsha

et al. 2020

IUBMB Life

View full text Add to dashboard Cite

show abstract

“…Physical exercise induces increased expression of IL‐6, IL‐10, and IL‐15 and inhibits TNF‐α expression, possibly delaying the onset and progression of arthritis 63 . However, physical training can also negatively affect RA, depending on the training overload in direct correlation with the degree of mechanical stress and mediators of local inflammation, exacerbating RA‐related joint dysfunction 64 . Thus, the application of different physical training protocols likely induces different inflammatory parameters in RA.…”

Section: Discussionmentioning

confidence: 99%

Effects of different physical training protocols on inflammatory markers in Zymosan‐induced rheumatoid arthritis in Wistar rats

Lima

Pedersen

Bomfim

et al. 2022

Cell Biochemistry & Function

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and involvement of the synovial membrane, causing joint damage and deformities. No effective drug treatment is available, and physical exercise has been utilized to alleviate the inflammatory processes. This study aimed to investigate the effects of different exercise training protocols on Zymosan-induced RA inflammatory markers in the right knee of Wistar rats. The rodents were subjected to aerobic, resisted, and combined physical training protocols with variations in the total training volume (50% or 100% of resistance and aerobic training volume) for 8 weeks. All physical training protocols reduced cachexia and systemic inflammatory processes. The histological results showed an increase in the inflammatory influx to the synovial tissue of the right knee in all physical training protocols. The rats that underwent combined physical training with reduced volume had a lower inflammatory influx compared to the other experimental groups. A reduction in the mRNA expression of inflammatory genes and an increase in anti-inflammatory gene expression were also observed. The physical training protocol associated with volume reduction attenuated systemic and synovial inflammation of the right knee, reducing the impact of Zymosan-induced RA in rats.

show abstract

“…Yokoyama et al previously reported that a single-nucleotide polymorphism (SNP) in IPMK, which is associated with decreased expression of IPMK, was detected in samples from tissues of Alzheimer’s disease and immune-mediated diseases including RA, suggesting that IPMK is a risk factor for chronic inflammatory diseases (Yokoyama et al 2016 ). Furthermore, a recent study reported that the IPMK expression levels in an adjuvant-induced arthritis rat model were lower after exercise-induced physical stress (González-Chávez et al 2019 ). Taken together, the above-described evidence and our in vivo findings indicate that myeloid IPMK promotes RA resolution and is therefore a key molecular target with important clinical implications for RA treatment.…”

Section: Discussionmentioning

confidence: 99%

Myeloid IPMK promotes the resolution of serum transfer-induced arthritis in mice

Ahn

Roh

Lee

et al. 2021

Animal Cells and Systems

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by widespread joint inflammation, which leads to joint damage, disability, and mortality. Among the several types of immune cells, myeloid cells such as macrophages are critical for controlling the pathogenesis of RA. Inositol phosphates are water-soluble signaling molecules, which are synthesized by a series of enzymes including inositol phosphate kinases. Previous studies revealed actions of inositol phosphates and their metabolic enzymes in the modulation of inflammation such as Toll-like receptor-triggered innate immunity. However, the physiological roles of inositol polyphosphate (IP) metabolism in the regulation of RA remain largely uncharacterized. Therefore, our study sought to determine the role of inositol polyphosphate multikinase (IPMK), a key enzyme for IP metabolism and various cellular signaling control mechanisms, in mediating RA. Using myeloid cell-specific IPMK knockout (KO) mice, arthritis was induced via intraperitoneal K/BxN serum injection, after which disease severity was evaluated. Both wild-type and IPMK KO mice developed similar RA phenotypes; however, conditional deletion of IPMK in myeloid cells led to elevated arthritis scores during the resolution phase, suggesting that IPMK deficiency in myeloid cells impairs the resolution of inflammation. Bone marrow-derived IPMK KO macrophages exhibited no apparent defects in immunoglobulin Fc receptor (FcR) activation, osteoclast differentiation, or resolvin signaling. Taken together, our findings suggest that myeloid IPMK is a key determinant of RA resolution.

show abstract

Exercise Exacerbates the Transcriptional Profile of Hypoxia, Oxidative Stress and Inflammation in Rats with Adjuvant-Induced Arthritis

Cited by 12 publications

References 50 publications

Antiarthritic effect of chitosan nanoparticle loaded with embelin against adjuvant‐induced arthritis in Wistar rats

Antiarthritic effect of chitosan nanoparticle loaded with embelin against adjuvant‐induced arthritis in Wistar rats

Effects of different physical training protocols on inflammatory markers in Zymosan‐induced rheumatoid arthritis in Wistar rats

Myeloid IPMK promotes the resolution of serum transfer-induced arthritis in mice

Contact Info

Product

Resources

About