Abstract:Nicotine‐craving progressively increases, or incubates, over abstinence following extended access self‐administration. While not yet examined for nicotine, the incubation of cocaine‐seeking is accompanied by changes in synaptic plasticity in the nucleus accumbens. Here, we determined whether such changes also accompany enhanced nicotine‐seeking following extended access self‐administration and abstinence, and whether exercise, a potential intervention for nicotine addiction, may exert its efficacy by normalizi… Show more
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