2021
DOI: 10.1038/s41380-021-01336-2
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Physical exercise rescues cocaine-evoked synaptic deficits in motor cortex

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Cited by 23 publications
(9 citation statements)
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“…Long-term exercise increases reward-related neural plasticity in brain structures, such as the dorsal striatum, nucleus accumbens, and lateral ventral tegmental area, and reduces MPA via its effects on reward stimulation ( Cassilhas et al, 2016 ). In empirical studies, physical exercise has been shown to improve a range of problems associated with symptoms of addiction, such as withdrawal and mood changes ( Chen et al, 2021 ; Cheng et al, 2021 ). These results suggest that physical exercise may provide valuable contribution to ameliorating MPA in college students.…”
Section: Discussionmentioning
confidence: 99%
“…Long-term exercise increases reward-related neural plasticity in brain structures, such as the dorsal striatum, nucleus accumbens, and lateral ventral tegmental area, and reduces MPA via its effects on reward stimulation ( Cassilhas et al, 2016 ). In empirical studies, physical exercise has been shown to improve a range of problems associated with symptoms of addiction, such as withdrawal and mood changes ( Chen et al, 2021 ; Cheng et al, 2021 ). These results suggest that physical exercise may provide valuable contribution to ameliorating MPA in college students.…”
Section: Discussionmentioning
confidence: 99%
“…METH exposure was administered as shown above. The moderate-intensity treadmill exercise program was modified from a mouse exercise protocol used in related studies ( Qu et al, 2020 ; Cheng et al, 2021 ). Treadmill exercise was carried out on a small animal treadmill (SA101B, SANS, China).…”
Section: Methodsmentioning
confidence: 99%
“…It has previously been shown that a week of low-intensity or moderate intensity running can enhance neurogenesis in the dentate gyrus of hippocampus, resulting in a significant increase in hippocampal BDNF mRNA expression (Lou et al, 2008). Cheng et al (2021) reported that 1-week running can restore the synaptic deficits induced by drug, improve in vivo spine formation, synaptic transmission, spontaneous activities of cortical pyramidal neurons, and motor -learning ability (Cheng et al, 2021). These findings confirm that the key mechanism of physical exercise to restore brain function is by promoting neurogenesis and synaptic function.…”
Section: Exercise and Malfunctions Of The Nervous Systems In Asdmentioning
confidence: 99%