Physical exercise rescues cocaine-evoked synaptic deficits in motor cortex

Cheng, Tao; Huang, Xiaodan; Hu, Xuefei; Wang, Siqi; Chen, Kai; Wei, Ji‐an; Lu, Yan; So, Kwok-Fai; Yuan, Ti‐Fei; Zhang, Li

doi:10.1038/s41380-021-01336-2

Cited by 27 publications

(17 citation statements)

References 44 publications

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“…[ 14–16 ] In the cortical region, we recently showed that repeated treadmill exercise facilitates spinogenesis and stabilization of newly formed synapses. [ 17–19 ] However, there is a major gap between exercise training and behavioral improvements due to the incomplete picture of how exercise is translated into synaptic modulations across multiple brain regions. To provide molecular explanations, it is worth noting that epigenetic regulation, such as histone modification, [ 20,21 ] microRNA, [ 22 ] and DNA methylation [ 23,24 ] all participate in mental and cognitive rehabilitation following exercise.…”

Section: Introductionmentioning

confidence: 99%

Physical Exercise Prevented Stress‐Induced Anxiety via Improving Brain RNA Methylation

Wei

Yang

et al. 2022

Advanced Science

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Physical exercise is effective in alleviating mental disorders by improving synaptic transmission; however, the link between body endurance training and neural adaptation has not yet been completely resolved. In this study, the authors investigated the role of RNA N6‐methyladenosine (m6A), an emerging epigenetic mechanism, in improved resilience against chronic restraint stress. A combination of molecular, behavioral, and in vivo recording data demonstrates exercise‐mediated restoration of m6A in the mouse medial prefrontal cortex, whose activity is potentiated to exert anxiolytic effects. Furthermore, it is revealed that hepatic biosynthesis of one methyl donor is necessary for exercise to improve brain RNA m6A to counteract environmental stress. This novel liver‐brain axis provides an explanation for brain network changes upon exercise training and provides new insights into the diagnosis and treatment of anxiety disorders.

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Section: Introductionmentioning

confidence: 99%

Physical Exercise Prevented Stress‐Induced Anxiety via Improving Brain RNA Methylation

Wei

Yang

et al. 2022

Advanced Science

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“…Long-term exercise increases reward-related neural plasticity in brain structures, such as the dorsal striatum, nucleus accumbens, and lateral ventral tegmental area, and reduces MPA via its effects on reward stimulation ( Cassilhas et al, 2016 ). In empirical studies, physical exercise has been shown to improve a range of problems associated with symptoms of addiction, such as withdrawal and mood changes ( Chen et al, 2021 ; Cheng et al, 2021 ). These results suggest that physical exercise may provide valuable contribution to ameliorating MPA in college students.…”

Section: Discussionmentioning

confidence: 99%

The relationship between physical exercise and mobile phone addiction among Chinese college students: Testing mediation and moderation effects

et al. 2022

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BackgroundDuring the COVID-19 pandemic, suspensions of activities and long periods of self-isolation led to a sharp increase in excessive use of mobile phones, which sparked public concern about mobile phone addiction (MPA). In recent years, more and more attention has been paid to physical exercise as a protective effect of MPA. However, more studies are needed to reveal this relationship and the exact mechanisms, based on which this study tested the mediating and moderating roles of self-control, rumination, psychological distress, and loneliness between physical exercise and MPA.MethodsIn this cross-sectional study, primary data was collected by questionnaire from 1,843 college students (19.75 ± 1.3) from five universities in Sichuan Province in Mainland China. Mobile Phone Addiction Tendency Scale (MPATS), Physical Activity Rating Scale-3 (PARS-3), Self-Control Scale (SCS), Ruminative Response Scale (RRS), Depression Anxiety Stress Scale-21 (DASS-21), and UCLA Loneliness Scale (UCLA-20) were investigated. The mediating models were examined using SPSS PROCESS macro 3.3 software, in which the mediation variables were self-control, rumination, and psychological distress, and the moderation was loneliness. Gender, major, and grade were included as control variables.ResultSelf-control, rumination, and psychological distress played a simple mediating role between physical exercise and MPA. Moreover, not only self-control and rumination but also self-control and psychological distress played the chain mediating roles between physical exercise and MPA. The chain pathways were moderated by loneliness. Specifically, the effect was more substantial among college students with higher loneliness.ConclusionThe conclusions corroborate and clarify that self-control, rumination, and psychological distress mediated the association between physical exercise and MPA, and the mediation effects were moderated via loneliness. This present study advanced our understanding of how and when college students’ physical exercise was related to MPA. It also illustrates that educators and parents should pay more attention to college students’ physical exercise.

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“…METH exposure was administered as shown above. The moderate-intensity treadmill exercise program was modified from a mouse exercise protocol used in related studies ( Qu et al, 2020 ; Cheng et al, 2021 ). Treadmill exercise was carried out on a small animal treadmill (SA101B, SANS, China).…”

Section: Methodsmentioning

confidence: 99%

Exercise modulates central and peripheral inflammatory responses and ameliorates methamphetamine-induced anxiety-like symptoms in mice

Li²,

Yang

et al. 2022

Front. Mol. Neurosci.

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Anxiety-like symptoms are common symptoms of methamphetamine (METH) users, especially in the acute withdrawal period, which is an important factor for the high relapse rate during METH acute withdrawal. Exercise has been demonstrated to relieve anxiety-like symptoms during METH withdrawal, but the underlying mechanisms of this anti-anxiety effect are still unclear. Activated microglia and abnormal neuroinflammation play an important role in the pathogenesis of anxiety-like symptoms after METH withdrawal. Moreover, peripheral immune factors were also significantly associated with anxiety symptoms. However, the effects of treadmill exercise on microglial function and neuroinflammation in the striatum and hippocampus during acute METH withdrawal have not been reported. In the current study, we found severe peripheral immune dysfunction in METH users during acute withdrawal, which may in part contribute to anxiety symptoms during METH acute withdrawal. We also showed that 2 weeks of METH exposure induced anxiety-like symptoms in the acute withdrawal period. Additionally, METH exposure resulted in increased microglial activation and proinflammatory cytokines released in the mouse striatum and hippocampus during acute withdrawal. We next evaluated the effects of treadmill exercise in countering anxiety-like symptoms induced by METH acute withdrawal. The results showed that anxiety-like symptoms induced by acute METH withdrawal were attenuated by coadministration of treadmill exercise. In addition, treadmill exercise counteracted METH-induced microglial activation in the mouse striatum and various subregions of the hippocampus. Furthermore, treadmill exercise also reversed the increase in proinflammatory cytokines induced by acute METH withdrawal in the mouse striatum, hippocampus and serum. Our findings suggest that the anti-anxiety effect of treadmill exercise may be mediated by reducing microglial activation and regulating central and peripheral inflammatory responses.

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Physical exercise rescues cocaine-evoked synaptic deficits in motor cortex

Cited by 27 publications

References 44 publications

Physical Exercise Prevented Stress‐Induced Anxiety via Improving Brain RNA Methylation

Physical Exercise Prevented Stress‐Induced Anxiety via Improving Brain RNA Methylation

The relationship between physical exercise and mobile phone addiction among Chinese college students: Testing mediation and moderation effects

Exercise modulates central and peripheral inflammatory responses and ameliorates methamphetamine-induced anxiety-like symptoms in mice

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