Exercise differentially regulates synaptic proteins associated to the function of BDNF

Vaynman, Shoshanna; Ying, Zhe; Yin, Dali; Gómez‐Pinilla, Fernando

doi:10.1016/j.brainres.2005.11.062

Cited by 216 publications

(152 citation statements)

References 41 publications

Supporting

Mentioning

138

Contrasting

Unclassified

Order By: Relevance

“…Physical exercise may thus prevent structural brain tissue loss, thereby attenuating declines in executive cognitive function by somewhat enhancing biological mechanisms. Insulin-like growth factor (IGF)-1 enhanced by exercise stimulus has been identified as a biological-hormonal factor preventing brain tissue loss, increasing the levels of key neurochemicals that improve plasticity and neuronal survival, such as brain-derived neurotrophin factor (BDNF) (Adlard et al, 2005;Cotman and Berchtold, 2002;Vaynman et al, 2006). Cassilhas et al (2007) found a significant increase in IGF-1 serum concentrations and improved executive cognitive function in a group that performed resistance training for 24 weeks compared with controls.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Short-term Strength Training on Health-related Quality of Life and Executive Cognitive Function

Kimura

Obuchi

Arai

et al. 2010

J Physiol Anthropol

View full text Add to dashboard Cite

Strength training has been reported as a potentially useful exercise to improve psychological aspects in the elderly, but its effects remain controversial. This study investigated the effectiveness of strength training conducted twice a week for 12 weeks for improving health-related quality of life (HRQOL) and executive cognitive function. The study was a single-blind randomized controlled trial with assessments before and after intervention. HRQOL and executive function were assessed using the SF-36 Health Status Survey and a computerized neuro-cognitive assessment using task-switch reaction time trials, respectively. Subjects comprised 119 participants Ն65 years old, randomized to either strength training (nϭ65) or health education classes (controls, nϭ54). The strength training program was designed to strengthen the large muscle groups most important for functional activities and to improve balance. The effects of the intervention on the eight dimensions of the SF-36 in the control and training groups were analyzed. Only the mental health scale of the SF-36 was significantly improved for the training group compared with controls after 12 weeks. Task-switch reaction time and correct response rate remained unchanged. Short-term strength training might have modest positive effects on HRQOL, although this training period may not be sufficient to affect executive function in relatively healthy older people.

show abstract

Section: Discussionmentioning

confidence: 99%

The Influence of Short-term Strength Training on Health-related Quality of Life and Executive Cognitive Function

Kimura

Obuchi

Arai

et al. 2010

J Physiol Anthropol

View full text Add to dashboard Cite

show abstract

“…Several reports have indicated that the TrkB-Fc fusion protein is effective in blocking BDNF effects, such as BDNFmediated N-methyl-D-aspartate-evoked responses (37), synaptic regulation (83), and noxious stimulation (63). To verify that BDNF decreases feeding and body weight gain via activation of TrkB, we used the TrkB-Fc fusion protein to block BDNF binding to its receptor.…”

Section: Discussionmentioning

confidence: 99%

Brain-derived neurotrophic factor in the ventromedial nucleus of the hypothalamus reduces energy intake

Wang

Bomberg²,

Levine³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Recent studies show that brainderived neurotrophic factor (BDNF) decreases feeding and body weight after peripheral and ventricular administration. BDNF mRNA and protein, and its receptor TrkB, are widely distributed in the hypothalamus and other brain regions. However, there are few reports on specific brain sites of actions for BDNF. We evaluated the effect of BDNF, given into the ventromedial nucleus of the hypothalamus (VMH), on normal and deprivation-and neuropeptide Y (NPY)-induced feeding behavior and body weight. BDNF injected unilaterally or bilaterally into the VMH of food-deprived and nondeprived rats significantly decreased feeding and body weight gain within the 0-to 24-h and the 24-to 48-h postinjection intervals. Doses effectively producing inhibition of feeding behavior did not establish a conditioned taste aversion. BDNF-induced feeding inhibition was attenuated by pretreatment of the TrkB-Fc fusion protein that blocks binding between BDNF and its receptor TrkB. VMH-injected BDNF significantly decreased VMH NPY-induced feeding at 1, 2, and 4 h after injection. In summary, BDNF in the VMH significantly decreases food intake and body weight gain, by TrkB receptor-mediated actions. Furthermore, the anorectic effects of BDNF in this site appear to be mediated by NPY. These data suggest that the VMH is an important site of action for BDNF in its effects on energy metabolism. food intake; body weight THE VENTROMEDIAL NUCLEUS OF THE HYPOTHALAMUS (VMH) is a brain area important to the regulation of energy metabolism. Early studies indicated that VMH lesions resulted in hyperphagia and obesity (28,38,66), whereas electrical stimulation of the VMH immediately suppressed feeding and induced lipolysis (65). Glucose-sensing neurons (7,27,55,74,75) and receptors for neuropeptides important to energy metabolism have been identified in the VMH, including leptin (13,17,20,22,51), melanocortin (26), neuropeptide Y (NPY) (43), corticotrophin-releasing hormone (49), CCK (12), insulin (33), and orexin (44) receptors. Many biological agents given into the VMH have been demonstrated to affect feeding. Food intake is inhibited by administration of histamine (4, 47), glucagon-like peptide 1 (70), serotonin agonists (25), urocortin (58), CCK (79), leptin (51), and insulin (78), whereas thyroid hormone (3,5,3Ј-triiodothyronine) (40), GABA or GABA agonists (32,34,35), norepinephrine (73), orexin (74), and NPY induce feeding after administration into the VMH (5,9,24,31,43,56,76).Anatomically, the VMH receives inputs from regions important to the regulation of energy metabolism, including the hypothalamic arcuate nucleus (ARC) (2, 14, 23), lateral hypothalamus (18, 67, 80), amygdala (45, 50), and lateral septum. The VMH also projects to ARC (77), paraventricular nucleus (PVN) (42, 52), lateral hypothalamus (72, 80), dorsomedial nucleus of the hypothalamus (46, 80), amygdala (6, 68), lateral septum (68), ventral tegmental area (68), nucleus accumbens (6), and nucleus of the solitary tract (6). These behavioral and neuroanatom...

show abstract

“…BDNF is found in the central nervous system and functions in areas associated with cognitive processes, such as the prefrontal cortex, striatum, hippocampus, cortex, septum neurons, cerebellum, and motor neurons. In addition, studies have indicated that IGF-1 enhances synaptic plasticity and neuronal survival, which would, in turn, improve cognitive performance (Adlard, Perreau, & Cotman, 2005;Cotman & Berchtold, 2002;Vaynman, Ying, Yin, & Gomez-Pinilla, 2006).…”

Section: Potential Mechanism Linking Resistance Exercise and Cognitionmentioning

confidence: 99%

Effect of Resistance-Exercise Training on Cognitive Function in Healthy Older Adults: A Review

Chang¹,

Pan²,

Chen³

et al. 2012

Journal of Aging and Physical Activity

165

121

View full text Add to dashboard Cite

Several studies have demonstrated that exercise helps reduce or prevent cognitive deterioration among older adults, and recent studies have further examined the effects of resistance-exercise training on cognition. The purpose of this review was to examine the role of resistance-exercise training on cognition in healthy older adults. Specifically, it describes the definition, health benefits, and the design of resistance-exercise training. The authors also review the research related to resistance exercises and cognition and found that this exercise modality may enhance specific cognitive performances. Next, they examine the potential mechanisms underlying resistance exercise and cognitive enhancement. Finally, they consider potential therapeutics and recommendations for further research on resistanceexercise training and cognition in older adults.

show abstract

Exercise differentially regulates synaptic proteins associated to the function of BDNF

Cited by 216 publications

References 41 publications

The Influence of Short-term Strength Training on Health-related Quality of Life and Executive Cognitive Function

The Influence of Short-term Strength Training on Health-related Quality of Life and Executive Cognitive Function

Brain-derived neurotrophic factor in the ventromedial nucleus of the hypothalamus reduces energy intake

Effect of Resistance-Exercise Training on Cognitive Function in Healthy Older Adults: A Review

Contact Info

Product

Resources

About