Exercise can restore behavioural and molecular changes of intergenerational morphine effects

Sadat‐Shirazi, Mitra‐Sadat; Zadeh-Tehrani, Setareh Nouri; Akbarabadi, Ardeshir; Mokri, Azarakhsh; Kasgari, Bahar Taleb Zadeh; Zarrindast, Mohammad‐Reza

doi:10.1111/adb.13122

Cited by 5 publications

(1 citation statement)

References 52 publications

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“…In the same way, exercise might have similar effects on sucrose intake, being protective against overconsumption of sweet drinks since the intake of both sucrose and drugs of abuse activates similar pathways in the brain [ 82 ]. Exercise has also been reported to increase D2R expression and protein levels in the NAcc [ 83 , 84 ], although conflicting reports have been published [ 85 ]. In older humans undergoing regular aerobic exercise at 40–80% of maximal heart rate (walking, jogging, or cycling) for 6 months, D2R availability, measured by PET scanning, was positively correlated with VO 2 max [ 86 ], indicating that physical fitness improves dopaminergic function.…”

Section: Discussionmentioning

confidence: 99%

Impact of Calorie-Restricted Cafeteria Diet and Treadmill Exercise on Sweet Taste in Diet-Induced Obese Female and Male Rats

et al. 2022

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The goal of the present study was to evaluate the sweet taste function in obese rats fed with a 30% calorie-restricted cafeteria diet (CAFR) and/or subjected to moderate treadmill exercise (12–17 m/min, 35 min, 5 days per week) for 9 weeks. A two-bottle preference test, a taste reactivity test, and a brief-access licking test were carried out when animals were aged 21 weeks; biometric and metabolic parameters were also measured along the interventions. Two separate experiments for females and males were performed. Behaviorally, CAF diet decreased sucrose intake and preference, as well as perceived palatability, in both sexes and decreased hedonic responses in males. Compared to the CAF diet, CAFR exerted a corrective effect on sweet taste variables in females by increasing sucrose intake in the preference test and licking responses, while exercise decreased sucrose intake in both sexes and licking responses in females. As expected, CAF diet increased body weight and Lee index and worsened the metabolic profile in both sexes, whereas CAFR diet ameliorated these effects mainly in females. Exercise had no noticeable effects on these parameters. We conclude that CAF diet might diminish appetitive behavior toward sucrose in both sexes, and that this effect could be partially reverted by CAFR diet in females only, while exercise might exert protective effects against overconsumption of sucrose in both sexes.

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Section: Discussionmentioning

confidence: 99%

Impact of Calorie-Restricted Cafeteria Diet and Treadmill Exercise on Sweet Taste in Diet-Induced Obese Female and Male Rats

et al. 2022

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Parental Exposure to Morphine Before Conception Decreases Morphine and Cocaine‐Induced Locomotor Sensitization in Male Offspring

Heidari,

Hajikarim‐Hamedani,

Hosseindoost

et al. 2024

Developmental Psychobiology

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Repeated exposure to abused drugs leads to reorganizing synaptic connections in the brain, playing a pivotal role in the relapse process. Additionally, recent research has highlighted the impact of parental drug exposure before gestation on subsequent generations. This study aimed to explore the influence of parental morphine exposure 10 days prior to pregnancy on drug‐induced locomotor sensitization. Adult male and female Wistar rats were categorized into morphine‐exposed and control groups. Ten days after their last treatment, they were mated, and their male offspring underwent morphine, methamphetamine, cocaine, and nicotine‐induced locomotor sensitization tests. The results indicated increased locomotor activity in both groups after drug exposure, although the changes were attenuated in morphine and cocaine sensitization among the offspring of morphine‐exposed parents (MEPs). Western blotting analysis revealed altered levels of D2 dopamine receptors (D2DRs) in the prefrontal cortex and nucleus accumbens of the offspring from MEPs. Remarkably, despite not having direct in utero drug exposure, these offspring exhibited molecular alterations affecting morphine and cocaine‐induced sensitization. The diminished sensitization to morphine and cocaine suggested the development of a tolerance phenotype in these offspring. The changes in D2DR levels in the brain might play a role in these adaptations.

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Preconception ethanol exposure changes anxiety, depressive and checking-like behavior and alter the expression levels of MAO-B in male offspring

Asefi,

Heidari,

Hajikarim-Hamedani

et al. 2024

Neurotoxicology and Teratology

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Exercise can restore behavioural and molecular changes of intergenerational morphine effects

Cited by 5 publications

References 52 publications

Impact of Calorie-Restricted Cafeteria Diet and Treadmill Exercise on Sweet Taste in Diet-Induced Obese Female and Male Rats

Impact of Calorie-Restricted Cafeteria Diet and Treadmill Exercise on Sweet Taste in Diet-Induced Obese Female and Male Rats

Parental Exposure to Morphine Before Conception Decreases Morphine and Cocaine‐Induced Locomotor Sensitization in Male Offspring

Preconception ethanol exposure changes anxiety, depressive and checking-like behavior and alter the expression levels of MAO-B in male offspring

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