Exercise and Prostate Cancer Risk in a Cohort of Veterans Undergoing Prostate Needle Biopsy

Antonelli, Jodi; Jones, Lee W.; Bañez, Lionel L.; Thomas, Jean A.; Anderson, Kelly; Taylor, Loretta; Gerber, Leah; Anderson, Tiffany; Hoyo, Catherine; Grant, Delores J.; Freedland, Stephen J.

doi:10.1016/j.juro.2009.07.028

Cited by 54 publications

(42 citation statements)

References 20 publications

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“…Our population represents patients at high risk for prostate cancer (elevated PSA and/or abnormal DRE) and thus may not be generalizable to all men at risk of prostate cancer. Moreover, we did not assess information on physical activity or diet, which are associated with DM, risk of prostate cancer, and potentially cancer grade at diagnosis (Antonelli et al, 2009). Finally, given DM is associated with other diseases and patients with DM usually receive specific therapeutic interventions (e.g., insulin therapy) and these data were also unavailable for all patients, we were not able to control for these potential confounders.…”

Section: Discussionmentioning

confidence: 99%

Diabetes Mellitus and HbA1c Levels Associated with High Grade Prostate Cancer

Özbek

Ötünçtemur²,

Dursun³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Pirpose: The aim of this study to analyze the association between history of diabetes mellitus (DM) with risk of prostate cancer (PCa) and cancer grade among men undergoing radical prostatectomy for PCa. Materials and Methods: 50 patients with DM and 50 patients without DM who undervent radical prostatectomy (RP) were included in the study. Age at biopsy, height, weight, digital rectal examination (DRE), pre-biopsy PSA levels, prostate volume, histopathologic diagnosis after surgery and gleason scores were collected data from all patients. Histologic material obtained at biopsy was given a Gleason score; tumours with a Gleason score ≥7 were considered high grade and <7 were considered low grade. Results: The mean age at the time of biopsy was 63.7 in patients with DM and 61.6 in patients without DM. Diabetic men had significantly lower PSA levels (p=0.01). Mean PSA level 7.04±2.85 in patients with DM and 8.7±2.86 in patients without DM, respectively. Also, diabetic men had higher RP tumor grade than men without DM (p=0.04). We found that HbA1c levels were higher in patients who have high grade prostate cancer (p<0.05). Conclusions: Diabetic men undergoing RP have lower PSA levels and have significantly higher grade PCa. We must be careful for screening PCa in patients with DM. Although the patients had lower PSA levels, they might have high grade disease.

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Section: Discussionmentioning

confidence: 99%

Diabetes Mellitus and HbA1c Levels Associated with High Grade Prostate Cancer

Özbek

Ötünçtemur²,

Dursun³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Several studies show that physically active prostate cancer patients have significantly greater quality of life 33,34 , less fatigue 35 , lower PSA levels 36 and can delay initiating ADT two years longer than their less-active prostate cancer peers 37 . Physically active prostate cancer patients also have significantly lower serum insulin and insulin-like growth factor (IGF-1), higher insulin-like growth factor binding protein (IGFBP-1) and a lower risk of high grade disease (Gleason score 7 or greater) compared to less-active prostate cancer patients [38][39][40] . Exercise is relatively inexpensive compared to pharmacological and/or radiation approaches 1 and has a social aspect that is important for older adults 41,42 and those with cancer 43,44 .…”

Section: Insert Figurementioning

confidence: 99%

Body Composition, Physical Fitness, Functional Performance, Quality of Life, and Fatigue Benefits of Exercise for Prostate Cancer Patients: A Systematic Review

Keogh

MacLeod

2012

Journal of Pain and Symptom Management

178

166

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Context: Prostate cancer patients, especially those on androgen deprivation therapy (ADT) experience many symptoms that make it difficult to maintain their independence and quality of life. As ADT act via reducing testosterone production, exercise may offset many of the ADT side-effects and that of the cancer itself. Objectives: This article sought to conduct a systematic review of the literature on whether exercise could reduce symptoms and improve quality of life for prostate cancer patients. Methods: Using relevant databases and keywords, 12 training studies were found meeting the inclusion and exclusion criteria. Results: Grade A level evidence was observed for the benefits of exercise in improving muscular endurance, aerobic endurance and overall quality of life as well as reducing fatigue in prostate cancer patients. Grade B evidence also suggested that exercise may improve prostate cancer patients' muscle mass, muscular strength, functional performance (walking and sit to stand speed) as well as health-related, social and physical quality of life. These effects appeared greater for group-rather than home-based exercise; especially if these programs including resistance training. Conclusion: It is recommended that most prostate cancer patients be encouraged to exercise regularly by their clinicians and significant others. Where possible, this exercise should be group-based and include some resistance training. Future research in this area should directly compare group-and home-based as well as resistance, aerobic and combined resistance and aerobic training to better elucidate the most effective forms of exercise for this population and what factors affect initiation and adherence to such programs.

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“…The details of the case-control study have been previously reported (Antonelli et al, 2009). In brief, male patients from the Durham Veterans Affairs Medical Center (DVAMC) in Durham, North Carolina, who were undergoing a prostate needle biopsy between January 2007 and July 2010, were recruited to enroll in a hospital-based, prostate cancer casecontrol study.…”

Section: Study Populationsmentioning

confidence: 99%

Association of Uridine Diphosphate-Glucuronosyltransferase 2B Gene Variants with Serum Glucuronide Levels and Prostate Cancer Risk

Grant

Hoyo

Oliver

et al. 2013

Genetic Testing and Molecular Biomarkers

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Aims: Uridine diphosphate-glucuronosyltransferase 2B (UGT2B) enzymes conjugate testosterone metabolites to enable their excretion in humans. The functional significance of the UGT2B genetic variants has never been described in humans. We evaluated UGT2B variants in relation to plasma androstane-3a,17b-diol-glucuronide (AAG) levels and the prostate cancer risk. Results: AAG levels were measured in sera from 150 controls and compared to the polymorphisms of UGT2B17, UGT2B15, and UGT2B7. Genomic DNA from controls (301) and cases (148) was genotyped for the polymorphisms, and odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression analyses. Having two copies of UGT2B17 was associated with higher AAG levels in controls among Whites ( p = 0.02), but not Blacks ( p = 0.82). Logistic regression models adjusting for age and race revealed that homozygosity for the G allele of the UGT2B15 D85Y polymorphism was directly associated with the prostate cancer risk (OR = 2.70, 95% CI = 1.28, 5.55). Conclusions: While the small sample size limits inference, our findings suggest that an association between the UGT2B17 copy number variant (CNV) and serum AAG levels in Whites, but unexpectedly not in Blacks. This novel observation suggests that genetic determinants of AAG levels in Blacks are unrelated to the UGT2B17 CNV. This study replicates the results that show an association of UGT215 D85Y with an increased prostate cancer risk.

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Exercise and Prostate Cancer Risk in a Cohort of Veterans Undergoing Prostate Needle Biopsy

Cited by 54 publications

References 20 publications

Diabetes Mellitus and HbA1c Levels Associated with High Grade Prostate Cancer

Diabetes Mellitus and HbA1c Levels Associated with High Grade Prostate Cancer

Body Composition, Physical Fitness, Functional Performance, Quality of Life, and Fatigue Benefits of Exercise for Prostate Cancer Patients: A Systematic Review

Association of Uridine Diphosphate-Glucuronosyltransferase 2B Gene Variants with Serum Glucuronide Levels and Prostate Cancer Risk

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