Diabetes Mellitus and HbA1c Levels Associated with High Grade Prostate Cancer

Özbek, Emin; Ötünçtemur, Alper; Dursun, Murat; Şahin, Süleyman; Beşiroğlu, Hüseyin; Köklü, İsmail; Erkoç, Mustafa; Danış, Eyyüp; Bozkurt, Muammer

doi:10.7314/apjcp.2014.15.6.2555

Cited by 13 publications

(5 citation statements)

References 37 publications

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“…This phenomenon may affect prostate cancer screening in patients with T1DM, producing false negative results in early stages of prostate cancer. A similar possible mechanism was described in T2DM, where higher risk of positive prostate biopsy and higher odds of more aggressive disease were reported [51,52]. Thus, these findings highlight the necessity to consider that diabetes may affect PSA levels and negatively influence prostate cancer screening in diabetic patients.…”

Section: Sex Hormonessupporting

confidence: 74%

The impact of type 1 diabetes mellitus on male sexual functions and sex hormone levels

et al. 2020

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Little is known about type 1 diabetes mellitus (T1DM) impact on the male sexual and reproductive functions. We aim to evaluate the influence of T1DM on male sexual function, quality of sexual life, and sex hormone levels. A total of 57 male patients aged 18 to 50 years (mean = 33) with T1DM (duration mean = 15 years) had a medical examination and completed a set of questionnaires-International Index of Erectile Function-5 (IIEF-5), Beck Depression Inventory (BDI) and Sexual quality of life questionnaire male (SQoL-M). The prevalence of erectile dysfunction was 28.1% (IIEF-5 ≤21). Patients without diabetic nephropathy had better erectile function (p = 0.008). Subjects with better glycemic control (HbA 1c <65 mmol/ mol) had also better erectile function (p = 0.041). At least 8.8% patients had retrograde ejaculation. Blood serum levels of sex hormones were determined and compared to laboratory reference values of healthy men. Total testosterone level was not significantly changed, sex hormone binding globulin was higher (p < 0.001) and its level correlated with daily insulin dose adjusted to body weight (p = 0.008). Free androgen index and calculated free testosterone were lower (p = 0.013; p < 0.001), estradiol was not significantly changed, LH was higher (p < 0.001), FSH was unchanged, and prolactin was higher (p < 0.001). Prostate-specific antigen (PSA) negatively correlated with HbA 1c (p < 0.001). To conclude, we found significant changes in sexual functions and sex hormone blood concentrations that indicate impairment of sexual and reproductive functions in T1DM males.

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Section: Sex Hormonessupporting

confidence: 74%

The impact of type 1 diabetes mellitus on male sexual functions and sex hormone levels

et al. 2020

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“…The protect study showed that DMII was inversely associated only with differentiated PCa (Gleason Score 2–6), but not with poorly differentiated PCa [27]. Other studies, however, showed an inverse association between DMII and PCa for both high and low-grade tumors [22,28,29].…”

Section: Resultsmentioning

confidence: 99%

Metabolic Alterations, Aggressive Hormone-Naïve Prostate Cancer and Cardiovascular Disease: A Complex Relationship

et al. 2019

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Background: Epidemiological studies suggest a possible relationship between metabolic alterations, cardiovascular disease and aggressive prostate cancer, however, no clear consensus has been reached. Objective: The aim of the study was to analyze the recent literature and summarize our experience on the association between metabolic disorders, aggressive hormone-naïve prostate cancer and cardiovascular disease. Method: We identified relevant papers by searching in electronic databases such as Scopus, Life Science Journals, and Index Medicus/Medline. Moreover, we showed our experience on the reciprocal relationship between metabolic alterations and aggressive prostate cancer, without the influence of hormone therapy, as well the role of coronary and carotid vasculopathy in advanced prostate carcinoma. Results: Prostate cancer cells have an altered metabolic homeostatic control linked to an increased aggressivity and cancer mortality. The absence of discrimination of risk factors as obesity, systemic arterial hypertension, diabetes mellitus, dyslipidemia and inaccurate selection of vascular diseases as coronary and carotid damage at initial diagnosis of prostate cancer could explain the opposite results in the literature. Systemic inflammation and oxidative stress associated with metabolic alterations and cardiovascular disease can also contribute to prostate cancer progression and increased tumor aggressivity. Conclusions: Metabolic alterations and cardiovascular disease influence aggressive and metastatic prostate cancer. Therefore, a careful evaluation of obesity, diabetes mellitus, dyslipidemia, systemic arterial hypertension, together with a careful evaluation of cardiovascular status, in particular coronary and carotid vascular disease, should be carried out after an initial diagnosis of prostatic carcinoma.

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“…In addition, patients in the lycopene plus FruHis group had a higher prevalence of diabetes compared with other intervention groups. There is evidence indicating significant associations of diabetes with serum levels of PSA and the risk of PC ( 46 , 47 ). The high prevalence of diabetes in the combined intervention may attenuate the reducing effects of lycopene plus FruHis intake on TPSA levels and this may explain why the TPSA-reducing effect of the combined treatment was not significant compared with the placebo.…”

Section: Discussionmentioning

confidence: 99%

FruHis significantly increases the anti-benign prostatic hyperplasia effect of lycopene: A double-blinded randomized controlled clinical trial

Sadeghi

Saedisomeolia²,

Jalili‐Baleh³

et al. 2022

Front. Nutr.

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BackgroundFor decades, lycopene was considered the main compound of tomato protecting benign prostatic hyperplasia (BPH). Recent animal studies suggest that a newly discovered compound “FruHis” boosts lycopene for its action. This study aimed to determine whether FruHis enhances the action of lycopene to modify the laboratory parameters and clinical outcomes of patients with BPH.Materials and methodsCurrent study was conducted on 52 BPH patients, who were randomly assigned into four groups of treatments: lycopene plus FruHis (n = 11, 25 mg/day lycopene and 10 mg/day FruHis), lycopene (n = 12, 25 mg/day lycopene), FruHis (n = 12, 10 mg/day FruHis), and placebo (n = 13). Patients received these supplements for 8 weeks.ResultsFruHis intake strengthened the reducing effects of lycopene on insulin-like growth factor-1 (IGF-1) (−54.47 ± 28.36 ng/mL in the lycopene + FruHis group vs. −30.24 ± 46.69 ng/mL in the lycopene group), total prostate-specific antigen (TPSA) (−1.49 ± 4.78 ng/mL in the lycopene + FruHis group vs. −0.64 ± 2.02 ng/mL in the lycopene group), and symptom score (−4.45 ± 4.03 in the lycopene + FruHis group vs. −1.66 ± 5.41 in the lycopene group) in BPH patients. Such findings were also seen for body mass index (BMI) and waist circumference (WC). However, except for IGF-1, these reductions were not statistically significant compared with the placebo, and the intakes of lycopene and FruHis alone, however, were clinically important. Such effects of lycopene and FruHis were not seen for free PSA (FPSA) and FPSA/TPSA ratio.ConclusionDespite the non-significant effects of lycopene and FruHis, it seems that FruHis intake strengthens the beneficial effects of lycopene on IGF-1, TPSA, and symptom scores among BPH patients.Clinical trial registration[www.irct.ir], identifier [IRCT20190522043669N1].

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Diabetes Mellitus and HbA1c Levels Associated with High Grade Prostate Cancer

Cited by 13 publications

References 37 publications

The impact of type 1 diabetes mellitus on male sexual functions and sex hormone levels

The impact of type 1 diabetes mellitus on male sexual functions and sex hormone levels

Metabolic Alterations, Aggressive Hormone-Naïve Prostate Cancer and Cardiovascular Disease: A Complex Relationship

FruHis significantly increases the anti-benign prostatic hyperplasia effect of lycopene: A double-blinded randomized controlled clinical trial

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