Exercise and Heart Failure

Piña, Ileana L.; Apstein, Carl S.; Balady, Gary J.; Belardinelli, Romualdo; Chaitman, Bernard R.; Duscha, Brian D.; Fletcher, Barbara J.; Fleg, Jerome L.; Myers, Jonathan; Sullivan, Mike

doi:10.1161/01.cir.0000055013.92097.40

Cited by 872 publications

(320 citation statements)

References 204 publications

Supporting

Mentioning

286

Contrasting

Unclassified

Order By: Relevance

“…Moreover, it has been established that ACE inhibitors can reduce blood pressure [40] . The current study, along with several others in the literature [41][42][43][44][45][46] , provided support for the notion that it would be advantageous to utilize exercise training instead of medicine to improve the function of the cardiovascular system. As our experiments suggested, the LHTL protocol could significantly decrease the ACE gene expression.…”

Section: Wwwchinapharcom Shi W Et Alsupporting

confidence: 70%

Living high training low induces physiological cardiac hypertrophy accompanied by down-regulation and redistribution of the renin-angiotensin system

et al. 2013

View full text Add to dashboard Cite

Aim: Living high training low" (LHTL) is an exercise-training protocol that refers living in hypoxia stress and training at normal level of O 2 . In this study, we investigated whether LHTL caused physiological heart hypertrophy accompanied by changes of biomarkers in reninangiotensin system in rats. Methods: Adult male SD rats were randomly assigned into 4 groups, and trained on living low-sedentary (LLS, control), living lowtraining low (LLTL), living high-sedentary (LHS) and living high-training low (LHTL) protocols, respectively, for 4 weeks. Hematological parameters, hemodynamic measurement, heart hypertrophy and plasma angiotensin II (Ang II) level of the rats were measured. The gene and protein expression of angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin II receptor I (AT 1 ) in heart tissue was assessed using RT-PCR and immunohistochemistry, respectively. Results: LLTL, LHS and LHTL significantly improved cardiac function, increased hemoglobin concentration and RBC. At the molecular level, LLTL, LHS and LHTL significantly decreased the expression of ACE, AGT and AT 1 genes, but increased the expression of ACE and AT 1 proteins in heart tissue. Moreover, ACE and AT 1 protein expression was significantly increased in the endocardium, but unchanged in the epicardium. Conclusion: LHTL training protocol suppresses ACE, AGT and AT1 gene expression in heart tissue, but increases ACE and AT 1 protein expression specifically in the endocardium, suggesting that the physiological heart hypertrophy induced by LHTL is regulated by regionspecific expression of renin-angiotensin system components.

show abstract

Section: Wwwchinapharcom Shi W Et Alsupporting

confidence: 70%

Living high training low induces physiological cardiac hypertrophy accompanied by down-regulation and redistribution of the renin-angiotensin system

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Although chronic exercise training has clearly been shown to be beneficial in attenuating risk factors for CVD, including high blood pressure and cholesterol levels, insulin resistance, and obesity (9,14,53,58), the utility of exercise as a clinical intervention for patients with developing CHF is less clear. Currently, there is a lack of clarity regarding the efficacy of chronic exercise training as a treatment and in reducing mortality for patients with CHF (47,59). Among the important considerations is whether or not exercise has the potential to improve the prognosis of patients with CHF or whether exercise places a further excessive demand on an already overstressed myocardium.…”

mentioning

confidence: 99%

Low-intensity exercise training delays onset of decompensated heart failure in spontaneously hypertensive heart failure rats

Emter

McCune²,

Sparagna³

et al. 2005

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

. Low-intensity exercise training delays onset of decompensated heart failure in spontaneously hypertensive heart failure rats. Am J Physiol Heart Circ Physiol 289: H2030 -H2038, 2005. First published July 1, 2005; doi:10.1152/ajpheart.00526.2005.-Data regarding the effectiveness of chronic exercise training in improving survival in patients with congestive heart failure (CHF) are inconclusive. Therefore, we conducted a study to determine the effect of exercise training on survival in a well-defined animal model of heart failure (HF), using the lean male spontaneously hypertensive HF (SHHF) rat. In this model, animals typically present with decompensated, dilated HF between ϳ18 and 23 mo of age. SHHF rats were assigned to sedentary or exercise-trained groups at 9 and 16 mo of age. Exercise training consisted of 6 mo of low-intensity treadmill running. Exercise training delayed the onset of overt HF and improved survival (P Ͻ 0.01), independent of any effects on the hypertensive status of the rats. Training delayed the myosin heavy chain (MyHC) isoform shift from ␣-to ␤-MyHC that was seen in sedentary animals that developed HF. Exercise was associated with a concurrent increase in cardiomyocyte length (Ϸ6%), width, and area and prevented the increase in the length-to-width ratio seen in sedentary animals in HF. The increases in proteinuria, plasma atrial natriuretic peptide, and serum leptin levels observed in rats with HF were suppressed by low-intensity exercise training. No significant alterations in sarco (endo)plasmic reticulum Ca 2ϩ ATPase, phospholamban, or Na ϩ / Ca 2ϩ exchanger protein expression were found in response to training. Our results indicate that 6 mo of low-intensity exercise training delays the onset of decompensated HF and improves survival in the male SHHF rat. Similarly, exercise intervention prevented or suppressed alterations in several key variables that normally occur with the development of overt CHF. These data support the idea that exercise may be a useful and inexpensive intervention in the treatment of HF. myosin heavy chain; proteinuria; cardiomyocyte morphology; atrial natriuretic peptide; leptin HEART DISEASE is a leading cause of death among men and women in Western industrialized societies. Cardiovascular disease (CVD) currently affects over 70 million Americans, 65 million of which are estimated to have high blood pressure and nearly 5 million are diagnosed with congestive heart failure (CHF) (2). With the diagnosis of CHF, life expectancy decreases dramatically and chances of survival decrease with 70 -80% of patients dying within 8 yr (2). Although chronic exercise training has clearly been shown to be beneficial in attenuating risk factors for CVD, including high blood pressure and cholesterol levels, insulin resistance, and obesity (9,14,53,58), the utility of exercise as a clinical intervention for patients with developing CHF is less clear. Currently, there is a lack of clarity regarding the efficacy of chronic exercise training as a treatment and in reducing mortali...

show abstract

“…Another limitation is the absence of a non‐exercising control group. However, including a control group without exercise was not possible due to ethical considerations, since routine care in our hospital entails that all patients with CHF are offered cardiac rehabilitation, and that exercise training is a class IA recommendation in both European and American guidelines 3, 4…”

Section: Discussionmentioning

confidence: 99%

“…Exercise training in patients with chronic heart failure (CHF) can positively impact physical fitness and health‐related quality of life1, 2 and is a class IA recommendation in both European and American guidelines 3, 4. Despite this, only a small portion of patients with CHF receive a customized, individual‐based exercise training programme 5.…”

Section: Introductionmentioning

confidence: 99%

Peripheral muscle training with resistance exercise bands in patients with chronic heart failure. Long‐term effects on walking distance and quality of life; a pilot study

et al. 2017

View full text Add to dashboard Cite

AimsThis study aimed to describe a method of peripheral muscle training with resistance bands in patients with chronic heart failure (CHF) and to evaluate its effects on the 6 min walk test and quality of life up to 12 months using a home‐based programme.Methods and resultsTwenty‐two patients with stable CHF (19 men and 3 women), mean age 63.2 years (SD 8.1), New York Heart Association class II–III were randomized to individual home‐based training (HT group), or home‐based training with a group‐based start‐up in a hospital setting (GT group). A 6 min walk test, the Minnesota Living with Heart Failure Questionnaire (MLHFQ), and Short Form with 36 items (SF‐36) were administered at baseline and after 3, 6, 9, and 12 months. Exercise training resulted in statistically significant increased walking distance in both groups. The HT group increased on average 107 (80) m from baseline to 12 months, and the GT group by 100 (96) m. Health‐related quality of life, measured with MLHFQ and SF‐36, reached statistically significant improvements in both groups but at different time points. There were no statistically significant differences between groups on any parameters or follow‐ups.ConclusionsLong‐term home‐based peripheral muscle training in patients with CHF, with or without an introductory period in a hospital setting, can be used for initial improvement and retention of walking distance and health‐related quality of life.

show abstract

Exercise and Heart Failure

Cited by 872 publications

References 204 publications

Living high training low induces physiological cardiac hypertrophy accompanied by down-regulation and redistribution of the renin-angiotensin system

Living high training low induces physiological cardiac hypertrophy accompanied by down-regulation and redistribution of the renin-angiotensin system

Low-intensity exercise training delays onset of decompensated heart failure in spontaneously hypertensive heart failure rats

Peripheral muscle training with resistance exercise bands in patients with chronic heart failure. Long‐term effects on walking distance and quality of life; a pilot study

Contact Info

Product

Resources

About