Exercise: An important component of treatment in the idiopathic inflammatory myopathies

Alexanderson, Helene

doi:10.1007/s11926-005-0063-2

Cited by 27 publications

(14 citation statements)

References 40 publications

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“…This cautious attitude is based on previous studies revealing increased creatine phosphokinase levels (CPK) and signs of inflammation in muscle tissue after excessive exercise in healthy individuals (8,9). Sev-eral studies demonstrating the safety of easy-to-moderate exercise programs and efficacy in reducing disability in patients with PM and DM have been published during the last decade (10 -18), and resistive exercise is now recommended in the rehabilitation of these patients (19,20).…”

Section: Introductionmentioning

confidence: 99%

Benefits of intensive resistance training in patients with chronic polymyositis or dermatomyositis

Alexanderson¹,

Dastmalchi²,

Esbjörnsson-Liljedahl³

et al. 2007

Arthritis & Rheumatism

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127

115

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Objective. To investigate the benefits and safety of an intensive muscular training program in patients with chronic polymyositis (PM) and dermatomyositis (DM).Methods. Nine patients with chronic PM or DM (median age 53 years, range 44 -61) were included. Assessments of impairment (10 -15 voluntary repetition maximum [VRM], the Functional Index 2 [FI-2], the Grippit, and pain rated on the Borg CR-10 scale), activity limitation (Myositis Activities Profile), and participation restriction (patients' disease impact on well-being) were performed 4 weeks prior to baseline, at baseline, and after 7 weeks of exercise. A 6-item core set of disease activity measures was administered and muscle biopsy samples of vastus lateralis were obtained at baseline and after 7 weeks of exercise. Response criteria at an individual level were set for disability and disease activity. The patients exercised 3 days per week for 7 weeks on loads allowing 10 VRM. Results. On a group level there were no significant differences between assessments at 4 weeks before baseline compared with baseline. The group improved significantly regarding 10 -15 VRM and FI-2 at 7 weeks compared with baseline (P < 0.05). All patients were responders with respect to impairment and 2 were activity limitation responders whereas participation restriction remained unchanged in all. Two patients were responders with reduced disease activity and no patient had signs of increased muscle inflammation in the muscle biopsy sample after 7 weeks of exercise. Conclusion. Patients with chronic, stable PM and DM can perform this intensive resistive exercise program with beneficial effects on impairment and activity limitation without increased muscle inflammation.

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Section: Introductionmentioning

confidence: 99%

Benefits of intensive resistance training in patients with chronic polymyositis or dermatomyositis

Alexanderson¹,

Dastmalchi²,

Esbjörnsson-Liljedahl³

et al. 2007

Arthritis & Rheumatism

Self Cite

127

115

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“…This hypothesis is supported by the findings in a small pilot study [40]. During the past decade, several reports have evaluated the benefits of exercise in patients with IIM [41]. Whether the positive effects of exercise in patients with polymyositis and dermatomyositis could be explained by a reduction in hypoxia and/or by an increased capillary density still needs to be determined.…”

Section: Muscle Dysfunction Induced By Non-immune Mechanismsmentioning

confidence: 71%

Pathogenesis of idiopathic inflammatory myopathies

Grundtman¹,

Lundberg

2006

Curr Rheumatol Rep

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The idiopathic inflammatory myopathies, myositis, are characterized by a chronic course with decreased muscle endurance and by infiltrates of T lymphocytes and macrophages in muscle tissue. Treatment with immunosuppressives rarely leads to recovery of muscle function, despite abolishment of inflammatory cell infiltrates in muscle tissue. Therefore, other mechanisms than immune-mediated muscle fiber damage are likely to contribute to the pathogenesis. One such non-immune-mediated muscle dysfunction could be caused by a disturbed microcirculation due to capillary loss or to phenotypically changed endothelial cells in the capillaries. These aberrations may affect the micro-environment of muscle tissue and lead to local tissue hypoxia with development of a secondary metabolic myopathy. Another possible non-immune-mediated mechanism leading to muscle dysfunction is the newly identified endoplasmatic reticulum (ER) stress response in myositis. The ER stress response is thought to be a consequence of the up-regulation of major histocompatibility complex class I in muscle fibers. These newly identified molecular pathways could play a major role in the pathogenesis of myositis and could be important targets in the development of new therapies.

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“…wg Myersa, nadaje im charakter taśm mięśniowych przechodzących nad więcej niż jednym stawem, wzajemnie zależnych podczas ruchu i przyjmowania postawy ciała. W warunkach patologicznych skrócenie długości jednej grupy mięśni powoduje rozluźnienie jej antagonistów [6][7][8][9][10].…”

Section: Analiza Zaburzeń Narządu Ruchuunclassified

Juvenile dermatomyositis – analysis of the musculoskeletal system and proposed physiotherapy

Żuk¹,

Żuk-Drążyk²,

Księżopolska-Orłowska³

et al. 2013

Reumatologia

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Młodzieńcze zapalenie skórno-mięśniowe jest rzadką chorobą autoimmunologiczną o nieustalonej etiologii zajmującą skórę, mięśnie i narządy wewnętrzne. Należy do grupy idiopatycznych zapalnych miopatii. W odróżnieniu od postaci występujących u dorosłych charakteryzuje się innym przebiegiem, np. występowaniem wapnicy w układzie szkieletowo-mięśniowym.<br /> Fizjoterapia jest leczeniem uzupełniającym podstawowe leczenie farmakologiczne. Zastosowana już we wczesnym okresie choroby zapobiega hipokinezji. Poprzez profilaktykę przykurczów oraz mobilizację mięśni posturalnych umożliwia przywrócenie utraconych funkcji aparatu ruchu i wpływa na poprawę samopoczucia młodocianych. Ze względu na specyfikę choroby oraz jej rzadkie występowanie u dzieci i młodzieży na podstawie klinicznych obserwacji układu ruchu chorych w pracy podjęto próbę opisania charakterystycznych zaburzeń funkcji oraz przedstawiono propozycję usprawniania.

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Exercise: An important component of treatment in the idiopathic inflammatory myopathies

Cited by 27 publications

References 40 publications

Benefits of intensive resistance training in patients with chronic polymyositis or dermatomyositis

Benefits of intensive resistance training in patients with chronic polymyositis or dermatomyositis

Pathogenesis of idiopathic inflammatory myopathies

Juvenile dermatomyositis – analysis of the musculoskeletal system and proposed physiotherapy

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