Benefits of intensive resistance training in patients with chronic polymyositis or dermatomyositis

Abstract

Objective. To investigate the benefits and safety of an intensive muscular training program in patients with chronic polymyositis (PM) and dermatomyositis (DM).Methods. Nine patients with chronic PM or DM (median age 53 years, range 44 -61) were included. Assessments of impairment (10 -15 voluntary repetition maximum [VRM], the Functional Index 2 [FI-2], the Grippit, and pain rated on the Borg CR-10 scale), activity limitation (Myositis Activities Profile), and participation restriction (patients' disease impact on well-being) were performed 4 weeks prior to baseline, at baseline, and after 7 weeks of exercise. A 6-item core set of disease activity measures was administered and muscle biopsy samples of vastus lateralis were obtained at baseline and after 7 weeks of exercise. Response criteria at an individual level were set for disability and disease activity. The patients exercised 3 days per week for 7 weeks on loads allowing 10 VRM. Results. On a group level there were no significant differences between assessments at 4 weeks before baseline compared with baseline. The group improved significantly regarding 10 -15 VRM and FI-2 at 7 weeks compared with baseline (P < 0.05). All patients were responders with respect to impairment and 2 were activity limitation responders whereas participation restriction remained unchanged in all. Two patients were responders with reduced disease activity and no patient had signs of increased muscle inflammation in the muscle biopsy sample after 7 weeks of exercise. Conclusion. Patients with chronic, stable PM and DM can perform this intensive resistive exercise program with beneficial effects on impairment and activity limitation without increased muscle inflammation.

A Longitudinal, Integrated, Clinical, Histological and mRNA Profiling Study of Resistance Exercise in Myositis

“…Eight autoimmune inflammatory myopathy patients (five patients with dermatomyositis and three with polymyositis) (11) participated in a resistance exercise program at the Karolinska University Hospital, Stockholm, Sweden (12). Median age was 51 years (range, 44-61 years), and median disease duration was 4.5 years (range, 2.7-29.0 years).…”

“…Median age was 51 years (range, 44-61 years), and median disease duration was 4.5 years (range, 2.7-29.0 years). More detailed clinical characteristics have previously been published (12). All patients had been treated with glucocorticoids and other immunosuppressive therapies for >12 months, with some improvement of muscle function but with persisting muscle function impairment.…”

Qualidade De Vida E a Força Muscular Em Um Indivíduo Portador De Dermatopolimiosite

“…Pode ser utilizado também como adjuvante em treinamentos de força, a fim de promover melhora significativa na reabilitação de força muscular em todos os ângulos de movimento (8) . Assim, entende-se, que a fisioterapia desempenha um papel fundamental na reabilitação dos portadores dessa doença por meio da recuperação e/ou manutenção da força muscular (9) e da qualidade de vida desses indivíduos. Baseado nisto, é que propomos avaliar a qualidade de vida e a força muscular de flexores e extensores de joelho pré e pós--intervenção fisioterapêutica em um indivíduo portador de dermatopolimiosite.…”

Juvenile dermatomyositis – analysis of the musculoskeletal system and proposed physiotherapy

“…wg Myersa, nadaje im charakter taśm mięśniowych przechodzących nad więcej niż jednym stawem, wzajemnie zależnych podczas ruchu i przyjmowania postawy ciała. W warunkach patologicznych skrócenie długości jednej grupy mięśni powoduje rozluźnienie jej antagonistów [6][7][8][9][10].…”