Exercise alleviates depression related systemic inflammation in chronic obstructive pulmonary disease patients

Sm, Abd El-Kader; Oh, Al-Jiffri

doi:10.4314/ahs.v16i4.25

Cited by 26 publications

(16 citation statements)

References 66 publications

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“…A meta-analysis has previously identified low mood and stress as two of the most significant barriers to exercise in mental illness [38]. However, exercise has also been demonstrated to improve mood associated with reduction in depression-associated inflammation in COPD [39] and in health [40]. A similar pattern has been seen with QoL where exercise specific self-efficacy has been shown to correlate with health related QoL in COPD [41].…”

Section: Perceived Symptom Burden Impacts Perceived Barriers To Exercisementioning

confidence: 84%

Patient perceived barriers to exercise and their clinical associations in difficult asthma

Freeman

Hill

Newell

et al. 2020

asthma res and pract

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Background: Exercise is recommended in guidelines for asthma management and has beneficial effects on symptom control, inflammation and lung function in patients with sub-optimally controlled asthma. Despite this, physical activity levels in patients with difficult asthma are often impaired. Understanding the barriers to exercise in people with difficult asthma is crucial for increasing their activity, and in implementing successful, disease modifying, and holistic approaches to improve their health. Methods: 62 Patients within the WATCH Difficult Asthma Cohort (Southampton, UK) completed an Exercise Therapy Burden Questionnaire (ETBQ). The results were analyzed with contemporaneous asthma-related data to determine relationships between perceived exercise barriers and asthma and comorbidity characteristics Results: Patients were reflective of a difficult asthma cohort, 66% were female, and 63% were atopic. They had a high BMI (median [inter-quartile range]) of 29.3 [25.5-36.2], age of 53.5 [38.75, 65.25], impaired spirometry with FEV1 73% predicted [59.5, 86.6%] and FEV/FVC ratio of 72 [56.5, 78.0] and poor symptom control, as defined by an Asthma Control Questionnaire (ACQ6) result of 2.4 [1.28, 3.2]. A high perceived barriers to exercise score was significantly correlated with increased asthma symptoms (r = 0.452, p < 0.0001), anxiety (r = 0.375, p = 0.005) and depression (r = 0.363, p = 0.008), poor quality of life (r = 0.345, p = 0.015) and number of rescue oral steroid courses in the past 12 months (r = 0.257, p = 0.048). Lung function, blood eosinophil count, FeNO, Njimegen and SNOT22 scores, BMI and hospitalisations in the previous year were not related to exercise perceptions. Conclusion: In difficult asthma, perceived barriers to exercise are related to symptom burden and psychological morbidity. Therefore, exercise interventions combined with psychological input such as CBT to restructure thought processes around these perceived barriers may be useful in facilitating adoption of exercise.

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Section: Perceived Symptom Burden Impacts Perceived Barriers To Exercisementioning

confidence: 84%

Patient perceived barriers to exercise and their clinical associations in difficult asthma

Freeman

Hill

Newell

et al. 2020

asthma res and pract

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“…Depression is commonly found in patients with chronic obstructive pulmonary disease. A study investigated the effect of aerobic exercise in chronic obstructive pulmonary disease patients [116]. They found aerobic exercise significantly decreased depression and peripheral inflammation markers including IL-6 in these patients.…”

Section: Exercisementioning

confidence: 99%

Role of Interleukin-6 in Depressive Disorder

Ting

Yang

Tsai

2020

IJMS

193

115

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Major depressive disorder (MDD), which is a leading psychiatric illness across the world, severely affects quality of life and causes an increased incidence of suicide. Evidence from animal as well as clinical studies have indicated that increased peripheral or central cytokine interleukin-6 (IL-6) levels play an important role in stress reaction and depressive disorder, especially physical disorders comorbid with depression. Increased release of IL-6 in MDD has been found to be a factor associated with MDD prognosis and therapeutic response, and may affect a wide range of depressive symptomatology. However, study results of the IL6 genetic effects in MDD are controversial. Increased IL-6 activity may cause depression through activation of hypothalamic-pituitary-adrenal axis or influence of the neurotransmitter metabolism. The important role of neuroinflammation in MDD pathogenesis has created a new perspective that the combining of blood IL-6 and other depression-related cytokine levels may help to classify MDD biological subtypes, which may allow physicians to identify the optimal treatment for MDD patients. To modulate the IL-6 activity by IL-6-related agents, current antidepressive agents, herb medication, pre-/probiotics or non-pharmacological interventions may hold great promise for the MDD patients with inflammatory features.

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“…Inflammation has an important role in the development and progression of COPD (35). SP-D is positively asso ciated with the severity of COPD, and SP-D may successfully differentiate COPD from other respiratory symptoms or diseases (36).…”

Section: Discussionmentioning

confidence: 99%

Effect of Pingchuan Guben decoction on patients with chronic obstructive pulmonary disease: Results from a randomized comparative effectiveness research trial

Qian

Fan

2017

Experimental and Therapeutic Medicine

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Exercise alleviates depression related systemic inflammation in chronic obstructive pulmonary disease patients

Cited by 26 publications

References 66 publications

Patient perceived barriers to exercise and their clinical associations in difficult asthma

Patient perceived barriers to exercise and their clinical associations in difficult asthma

Role of Interleukin-6 in Depressive Disorder

Effect of Pingchuan Guben decoction on patients with chronic obstructive pulmonary disease: Results from a randomized comparative effectiveness research trial

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