Exendin-4 and exercise promotes β-cell function and mass through IRS2 induction in islets of diabetic rats

Park, Sunmin; Hong, Sang Mee; Sung, So Ra

doi:10.1016/j.lfs.2007.12.018

Cited by 35 publications

(28 citation statements)

References 58 publications

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“…In previous studies using high-fat fed, 90% pancreatectomized rat models, exercise training decreased pancreatic apoptosis (34,35). In the current study of a more modest pancreatic insult, we found no such changes in the number of apoptotic nuclei within islets, but given that Restricted offspring did not present with increased apoptosis in the sedentary state, it is not surprising that exercise training had no effect.…”

Section: Effect Of Small Birth Weight (Restricted) or Altered Postnatcontrasting

confidence: 59%

“…In the current study of a more modest pancreatic insult, we found no such changes in the number of apoptotic nuclei within islets, but given that Restricted offspring did not present with increased apoptosis in the sedentary state, it is not surprising that exercise training had no effect. Furthermore, previous studies have reported augmented insulin/IGF-1, IRS-2, Akt, and Pdx1 signaling immediately after exercise (34,35). Whether these mechanisms mediate our findings of chronic and long-term morphological benefits of exercise training on ␤-cell mass has yet to be determined.…”

Section: Effect Of Small Birth Weight (Restricted) or Altered Postnatmentioning

confidence: 69%

“…Endurance exercise training in diabetic patients and rodent models of diabetes improves whole body insulin sensitivity and glucose tolerance, as well as yielding pancreatic-specific benefits (9,14,34,35). Lowering of blood glucose, as occurs with exercise training, has been suggested to reduce glucotoxicity on pancreatic ␤-cells, allowing for improved function and regeneration.…”

mentioning

confidence: 99%

“…Lowering of blood glucose, as occurs with exercise training, has been suggested to reduce glucotoxicity on pancreatic ␤-cells, allowing for improved function and regeneration. Indeed, treadmill exercise training in partially pancreatectomized young male rats is associated with increased insulin secretion along with increased ␤-cell mass (34,35). As there is significant plasticity of the pancreas during early life (25,38,44,46), this may represent a critical period that responds optimally to intervention.…”

mentioning

confidence: 99%

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Short-term exercise training early in life restores deficits in pancreatic β-cell mass associated with growth restriction in adult male rats

Laker

Gallo

Wlodek

et al. 2011

American Journal of Physiology-Endocrinology and Metabolism

129

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Fetal growth restriction is associated with reduced pancreatic β-cell mass, contributing to impaired glucose tolerance and diabetes. Exercise training increases β-cell mass in animals with diabetes and has long-lasting metabolic benefits in rodents and humans. We studied the effect of exercise training on islet and β-cell morphology and plasma insulin and glucose, following an intraperitoneal glucose tolerance test (IPGTT) in juvenile and adult male Wistar-Kyoto rats born small. Bilateral uterine vessel ligation performed on day 18 of pregnancy resulted in Restricted offspring born small compared with sham-operated Controls and also sham-operated Reduced litter offspring that had their litter size reduced to five pups at birth. Restricted, Control, and Reduced litter offspring remained sedentary or underwent treadmill running from 5 to 9 or 20 to 24 wk of age. Early life exercise increased relative islet surface area and β-cell mass across all groups at 9 wk, partially restoring the 60–68% deficit ( P < 0.05) in Restricted offspring. Remarkably, despite no further exercise training after 9 wk, β-cell mass was restored in Restricted at 24 wk, while sedentary littermates retained a 45% deficit ( P = 0.05) in relative β-cell mass. Later exercise training also restored Restricted β-cell mass to Control levels. In conclusion, early life exercise training in rats born small restored β-cell mass in adulthood and may have beneficial consequences for later metabolic health and disease.

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Section: Effect Of Small Birth Weight (Restricted) or Altered Postnatcontrasting

confidence: 59%

Section: Effect Of Small Birth Weight (Restricted) or Altered Postnatmentioning

confidence: 69%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Short-term exercise training early in life restores deficits in pancreatic β-cell mass associated with growth restriction in adult male rats

Laker

Gallo

Wlodek

et al. 2011

American Journal of Physiology-Endocrinology and Metabolism

129

View full text Add to dashboard Cite

show abstract

“…5,7 Studies in obese or diabetic rodent models have shown that exercise counter-regulates the IRS2-PI3K-pAkt growth pathway attenuated in Langerhans islet resulting in a bigger b cell area, major b cell proliferation rate and lower apoptosis. 10,11,12 On the other hand, in healthy state, the endurance training enhances the growth pathway in pancreas islet, with a higher phosphorylation levels for Akt, AS160, and mTOR, compared with the sedentary condition. 13 The last result, reduces the proapoptotic marker (BAX protein) and increases the anti-apoptotic markers (Bcl-2).…”

Section: Introductionmentioning

confidence: 99%