Executive Summary: Heart Disease and Stroke Statistics—2012 Update

Roger, Véronique L.; Go, Alan S.; Lloyd‐Jones, Donald M.; Benjamin, Emelia J.; Berry, Jarett D.; Borden, William B.; Bravata, Dawn M.; Dai, Shifan; Ford, Earl S.; Fox, Caroline S.; Fullerton, Heather J.; Gillespie, Cathleen; Hailpern, Susan M.; Heit, John A.; Howard, Virginia J.; Kissela, Brett M.; Kittner, Steven J.; Lackland, Daniel T.; Lichtman, Judith H.; Lisabeth, Lynda D.; Makuc, Diane M.; Marcus, Gregory M.; Marelli, Ariane J.; Matchar, David B.; Moy, Claudia S.; Mozaffarian, Dariush; Mussolino, Michael E.; Nichol, Graham; Paynter, Nina P.; Soliman, Elsayed Z.; Sorlie, Paul D.; Sotoodehnia, Nona; Turan, Tanya N.; Virani, Salim S.; Wong, Nathan D.; Woo, Daniel; Turner, Melanie B.

doi:10.1161/cir.0b013e3182456d46

Cited by 1,147 publications

(543 citation statements)

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“…Cardiovascular diseases continue to be the leading cause of death in most industrialized nations of the world 1, 2. Unfortunately, the first sign of cardiovascular disease is often the last, as the first sign is often sudden cardiac arrest.…”

Section: Introductionmentioning

confidence: 99%

Cardiocerebral and cardiopulmonary resuscitation – 2017 update

Ewy

2017

Acute Medicine & Surgery

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Sudden cardiac arrest is a major public health problem in the industrialized nations of the world. Yet, in spite of recurrent updates of the guidelines for cardiopulmonary resuscitation and emergency cardiac care, many areas have suboptimal survival rates. Cardiocerebral resuscitation, a non‐guidelines approach to therapy of primary cardiac arrest based on our animal research, was instituted in Tucson (AZ, USA) in 2002 and subsequently adopted in other areas of the USA. Survival rates of patients with primary cardiac arrest and a shockable rhythm significantly improved wherever it was adopted. Cardiocerebral resuscitation has three components: the community, the pre‐hospital, and the hospital. The community component emphasizes bystander recognition and chest compression only resuscitation. Its pre‐hospital or emergency medical services component emphasizes: (i) urgent initiation of 200 uninterrupted chest compressions before and after each indicated single defibrillation shock, (ii) delayed endotracheal intubation in favor of passive delivery of oxygen by a non‐rebreather mask, (iii) early adrenaline administration. The hospital component was added later. The national and international guidelines for cardiopulmonary resuscitation and emergency medical services are still not optimal, for several reasons, including the fact that they continue to recommend the same approach for two entirely different etiologies of cardiac arrest: primary cardiac arrest, often caused by ventricular fibrillation, where the arterial blood oxygenation is little changed at the time of the arrest, and secondary cardiac arrest from severe respiratory insufficiency, where the arterial blood is severely desaturated at the time of cardiac arrest. These different etiologies need different approaches to therapy.

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Section: Introductionmentioning

confidence: 99%

Cardiocerebral and cardiopulmonary resuscitation – 2017 update

Ewy

2017

Acute Medicine & Surgery

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“…HF affects approximately 5.7 million patients in the United States and it is predicted that by the year 2030 an additional 3 million Americans will have HF, representing an astounding 25% increase from 2010 (1) . As a consequence, the management of HF accounts for one of the biggest burdens on health care expenditure.…”

Section: Introductionmentioning

confidence: 99%

His Bundle Pacing Or Biventricular Pacing For Cardiac Resynchronization Therapy In Heart Failure: Discovering New Methods For An Old Problem

Sharma

Vijayaraman

2016

Journal of Atrial Fibrillation

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“…Myocardial infarction (MI) is the leading cause of death in the world [1] . The classical risk factors for mortality after MI include depressed ventricular function [2] , severe coronary atherosclerosis [3] , and persistent complex ventricular arrhythmias [4] .…”

Section: Introductionmentioning

confidence: 99%

Ketanserin improves cardiac performance after myocardial infarction in spontaneously hypertensive rats partially through restoration of baroreflex function

Zhang

Liu

et al. 2013

Acta Pharmacol Sin

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Aim: Baroreflex dysfunction is associated with a higher rate of sudden death after myocardial infarction (MI). Ketanserin enhances baroreflex function in rats. The present work was designed to examine whether ketanserin improves the post-MI cardiac function and to explore the possible mechanism involved. Methods: Spontaneously hypertensive rats (SHR) were treated with ketanserin (0.3 mg·kg -1 ·d -1 ). Two weeks later, blood pressure and baroreflex function were measured, followed by a ligation of the left coronary artery. The expressions of vesicular acetylcholine transporter (VAChT) and α7 nicotinic acetylcholine receptor (α7-nAChR) in ischemic myocardium, angiogenesis, cardiac function, and left ventricular (LV) remodeling were evaluated subsequently. Results: Ketanserin significantly improved baroreflex sensitivity (0.62±0.21 vs 0.34±0.12 ms/mmHg, P<0.01) and vagal tonic activity (heart rate changes in response to atropine, 54.8±16.2 vs 37.6±13.4 bpm, P<0.01) without affecting the blood pressure or basic heart rate in SHR. Treatment of SHR with ketanserin prominently improved cardiac function and alleviated LV remodeling, as reflected by increases in the ejection fraction, fractional shortening, and LV systolic pressure as well as decreases in LV internal diameter and LV relative weight. The capillary density, vascular endothelial growth factor expression, and blood flow in the ischemic myocardium were significantly higher in the ketanserin-treated group. In addition, ketanserin markedly increased the expression of VAChT and α7-nAChR in ischemic myocardium. Conclusion: Ketanserin improved post-MI cardiac function and angiogenesis in ischemic myocardium. The findings provide a mechanistic basis for restoring baroreflex function using ketanserin in the treatment of MI.

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Executive Summary: Heart Disease and Stroke Statistics—2012 Update

Cited by 1,147 publications

References 0 publications

Cardiocerebral and cardiopulmonary resuscitation – 2017 update

Cardiocerebral and cardiopulmonary resuscitation – 2017 update

His Bundle Pacing Or Biventricular Pacing For Cardiac Resynchronization Therapy In Heart Failure: Discovering New Methods For An Old Problem

Ketanserin improves cardiac performance after myocardial infarction in spontaneously hypertensive rats partially through restoration of baroreflex function

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