Executive dysfunction in chronic cocaine users: An exploratory study

Madoz-Gúrpide, Agustín; Blasco-Fontecilla, Hilario; Baca‐García, Enrique; Mangado, Enriqueta Ochoa

doi:10.1016/j.drugalcdep.2010.11.030

Cited by 56 publications

(39 citation statements)

References 42 publications

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“…intake of cocaine of ~20 mg/kg (or ~10 mg/kg/hr), which falls near the range of hourly cocaine intakes (12–20 mg/kg) reported after escalation in extended access models (e.g., Allen et al 2007; Carroll et al 2010; Knackstedt et al 2007; Liu et al 2005). As abstinent cocaine abusers with prefrontal deficits are reported to use ~10–20 mg/kg/day (e.g., Bolla et al 2003; Madoz-Gúrpide et al 2011), the present study effectively serves as a model of set shifting performance of individuals who abused cocaine during adolescence or adulthood.…”

Section: Discussionmentioning

confidence: 99%

“…Concerning attentional networks, cocaine abusers have problems with sustained attention during abstinence, with effect sizes between 0.40 and 1.10 across multiple studies (Jovanovski et al 2005). During the Wisconsin Card Sorting Test, which measures behavioral flexibility, abstinent cocaine abusers are likely to make more perseverative errors and complete fewer categories than healthy controls, which are outcomes indicative of executive and attentional impairment (Madoz-Gúrpide et al 2011; Woicik et al 2011). …”

Section: Introductionmentioning

confidence: 99%

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Performance on a strategy set shifting task in rats following adult or adolescent cocaine exposure

et al. 2014

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Rationale Neuropsychological testing is widespread in adult cocaine abusers, but lacking in teens. Animal models may provide insight into age-related neuropsychological consequences of cocaine exposure. Objectives Determine whether developmental plasticity protects or hinders behavioral flexibility after cocaine exposure in adolescent vs. adult rats. Methods Using a yoked-triad design, one rat controlled cocaine delivery and the other two passively received cocaine or saline. Rats controlling cocaine delivery (1.0 mg/kg) self-administered for 18 sessions (starting P37 or P77), followed by 18 drug-free days. Rats next were tested in a strategy set shifting task, lasting 11–13 sessions. Results Cocaine self-administration did not differ between age groups. During initial set formation, adolescent-onset groups required more trials to reach criterion and made more errors than adult-onset groups. During the set shift phase, rats with adult-onset cocaine self-administration experience had higher proportions of correct trials and fewer perseverative + regressive errors than age-matched yoked-controls or rats with adolescent-onset cocaine self-administration experience. During reversal learning, rats with adult-onset cocaine experience (self-administered or passive) required fewer trials to reach criterion and the self-administering rats made fewer perseverative + regressive errors than yoked-saline rats. Rats receiving adolescent-onset yoked-cocaine had more trial omissions and longer lever press reaction times than age-matched rats self-administering cocaine or receiving yoked-saline. Conclusions Prior cocaine self-administration may impair memory to reduce proactive interference during set shifting and reversal learning in adult-onset but not adolescent-onset rats (developmental plasticity protective). Passive cocaine may disrupt aspects of executive function in adolescent-onset but not adult-onset rats (developmental plasticity hinders).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Performance on a strategy set shifting task in rats following adult or adolescent cocaine exposure

et al. 2014

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“…ACCEPTED MANUSCRIPT Morein-Zamir, Robbins, & Bullmore, 2011;Madoz-Gúrpide, Blasco-Fontecilla, Baca-García, & Ochoa-Mangado, 2011;Sullivan, Fama, Rosenbloom, & Pfefferbaum, 2002).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Sensation seeking and executive deficits in relation to alcohol, tobacco, and marijuana use frequency among university students: Value of ecologically based measures

Meil

LaPorte

Mills

et al. 2016

Addictive Behaviors

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“…Chronic use of cocaine is related to poorer executive functioning, affecting capacity for inhibition, mental flexibility, planning ability, alternation of cognitive sets and decision-making (Colzato et al, 2009;Madoz-Gúrpide, Blasco-Fontecilla, & Baca-García, 2011;Morie, De Sanctis, & Foxe, 2014;Pike, Stoopsa, Fillmore, & Rush, 2013;Verdejo-García & Pérez-García, 2007;van der Plas et al, 2009;Woicik et al, 2009;2011). This altered functioning has not only been found in adults: children and teenagers prenatally exposed to high levels of cocaine also present such deficits (Betancourt et al, 2011;Bridgett & Mayes, 2011;Grewen et al, 2014;Landi et al, 2012).…”

Section: Executive Functioningmentioning

confidence: 99%

Déficits neuropsicológicos asociados a la relación entre abuso de cocaína y violencia: mecanismos neuronales facilitadores

Romero‐Martínez

Moya-Albiol

2015

Adicciones

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Introducción. El abuso de la cocaína, así como la exposición prenatal a la misma parece ser un factor relevante en el desencadenamiento de comportamientos violentos. Los déficits neuropsicológicos, así como el género y la combinación con el alcohol, serían los posibles mecanismos facilitadores. Objetivo. Revisar y recapitular los resultados obtenidos sobre los déficits neuropsicológicos debidos al abuso o a la exposición prenatal a la cocaína y relacionarlos con la expresión de la violencia. Además, se enfatiza el papel del género y el abuso del alcohol junto a la cocaína, así como la posible existencia de daño orgánico cerebral como mecanismos facilitadores. Desarrollo. Se ha revisado la bibliografía científica usando los buscadores Google Scholar, PsycINFO, PubMed, Medline e ISI Web of Knowledge. Conclusiones.La cocaína facilitaría la expresión de la violencia debido a los déficits en la decodificación emocional, la capacidad de abstracción e inhibición, así como en las habilidades verbales y mnémicas. Esto explicaría, además, los problemas en la toma de decisiones. Los déficits y la expresión de la violencia parecen ser más evidentes en los hombres. Sin embargo, a pesar de que la combinación de la cocaína con el alcohol incrementaría el riesgo de reaccionar de forma violenta, los déficits no serían mayores que el consumo de cada una de ellas por separado.Estos déficits podrían ser producto de un funcionamiento anormal de algunas áreas del lóbulo frontal (especialmente el prefrontal) y el parietal, así como estructuras subcorticales como la amígdala. Todo ello permitiría planificar estrategias de intervención cuyos objetivos serían estos dominios cognitivos.

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Executive dysfunction in chronic cocaine users: An exploratory study

Cited by 56 publications

References 42 publications

Performance on a strategy set shifting task in rats following adult or adolescent cocaine exposure

Performance on a strategy set shifting task in rats following adult or adolescent cocaine exposure

Sensation seeking and executive deficits in relation to alcohol, tobacco, and marijuana use frequency among university students: Value of ecologically based measures

Déficits neuropsicológicos asociados a la relación entre abuso de cocaína y violencia: mecanismos neuronales facilitadores

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